Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development

Autonomous active exploration for tactile sensing in robotics

The sense of touch permits humans to directly touch, feel and perceive the state of their surrounding environment. For an exploration task, humans normally reduce uncertainty by actively moving their hands and fingers towards more interesting locations. This active exploration is a sophisticated procedure that involves sensing and perception processes. In robotics, the sense of touch also plays an important role for the development of intelligent systems capable to safely explore and interact with their environment. However, robust and accurate sensing and perception methods, crucial to exploit the benefits offered by the sense of touch, still represents a major research challenge in the field of robotics. A novel method for sensing and perception in robotics using the sense of touch is developed in this research work. This novel active Bayesian perception method, biologically inspired by humans, demonstrates its superiority over passive perception modality, achieving accurate tactile perception with a biomimetic fingertip sensor. The accurate results are accomplished by the accumulation of evidence through the interaction with the environment, and by actively moving the biomimetic fingertip sensor towards better locations to improve perception as humans do. A contour following exploration, commonly used by humans to extract object shape, was used to validate the proposed method using simulated and real objects. The exploration procedure demonstrated the ability of the tactile sensor to autonomously interact, performing active movements to improve the perception from the contour of the objects being explored, in a natural way as humans do. An investigation of the effects on the perception and decisions taken by the combination of the experience acquired along an exploration task with the active Bayesian perception process is also presented. This investigation, based on two novel sensorimotor control strategies (SMC1 and SMC2), was able to improve the performance in speed and accuracy of the exploration task. To exploit the benefits of the control strategies in a realistic exploration, the learning of a forward model and confidence factor was needed. For that reason, a novel method based on the combination of Predicted Information Gain (PIG) and Dynamic Bayesian Networks (DBN) permitted to achieve an online and adaptive learning of the forward model and confidence factor, allowing to improve the performance of the exploration task for both sensorimotor control strategies. Overall, the novel methods presented in this thesis, validated in simulated and real environments, demonstrated to be robust, accurate and suitable for robots to perform autonomous active perception and exploration using the sense touch

Data-driven Technology Foresight: Text Analysis of Emerging Technologies

학위논문 (박사)-- 서울대학교 대학원 : 공과대학 산업·조선공학부, 2018. 2. 박용태.This dissertation argues for new directions in the field of technology foresight. Technology foresight was formulated on the basis of qualitative and participatory research. Initially, most foresight activities were triggered by the prospect of a handful number of experts, but recent studies highlight theoretical paradigm shifts toward a more comprehensive and data-driven approach to creating shared insights on the future of emerging technologies. Much of the research up to now, however, has been descriptive in nature, and a definite method of realizing the notion has not yet been addressed in the existing literature to a large extent. To this end, we have attempted to formalize the concept of data-driven technology foresight by incorporating unconventional data sources – future-oriented web data, Wikipedia data, and scientific publication data – and different analytical tools – Latent Semantic Analysis, IdeaGraph, and Morphological Analysis. Four distinct foresight frameworks were proposed for the proactive management process of emerging technologies: impact identification, impact analysis, plan development, and technology ideation. The study was guided by the following research questions: (1) what kinds of data sources are available on the web and which of those are considered useful in foresight studies? (2) Where could we incorporate these data sources and which techniques are most suitable for the given purposes? (3) Which foresight-related fields would particularly benefit from applying a data-driven approach and what are the positive effects? The proposals outlined should be considered exploratory and open-ended. It is designed to determine the nature of the problem, rather than to offer definitive and conclusive answers. Nevertheless, the proposed scheme may well provide not just a rationale but a theoretical grounding for this newly introduced notion. This dissertation is expected to yield a foothold for the readers to better comprehend and act on this new shift in the field of technology foresight.Chapter 1 Introduction 1 1.1 Emergence of Technology Foresight 1 1.2 Towards a Data-driven Technology Foresight 3 1.3 Problem Statement 6 1.4 Dissertation Overview 8 Chapter 2 Data Sources and Methodologies 15 2.1 Data Sources 15 2.1.1 Future-oriented Web Data 15 2.1.2 Wikipedia Data 17 2.1.3 Scientific Publication Data 19 2.2 Methodologies 21 2.2.1 Latent Semantic Analysis (LSA) 21 2.2.2 IdeaGraph 25 2.2.3 Morphological Analysis (MA) 29 Chapter 3 Foresight for Impact Identification 31 3.1 Introduction 32 3.2 Emerging Technology and its Social Impacts 36 3.2.1 Distinctive Nature of Emerging Technology 36 3.2.2 Technology Assessment 39 3.3 LSA for Constructing Scenarios 43 3.4 Research Framework 44 3.4.1 Step 1: Data Collection 46 3.4.2 Step 2: Scenario Development 49 3.4.2.1 Pre-LSA: Preprocessing Future-oriented Web Data 49 3.4.2.2 LSA: Applying Latent Semantic Analysis 52 3.4.2.3 Post-LSA: Constructing Scenarios 54 3.5 Illustrative Case Study: Drone Technology 55 3.6 Discussion 65 3.6.1 Categorization of Social Impacts 65 3.6.2 Comparative Analysis 72 3.6.3 Implication for Theory, Practice, and Policy 74 3.7 Conclusion 76 Chapter 4 Foresight for Impact Analysis 79 4.1 Introduction 80 4.2 Uncertainty and Complexity 82 4.3 Data-driven Foresight Process 84 4.4 Scenario Building Beyond the Obvious 86 4.4.1 Capturing Plausibility using LSA 90 4.4.2 Capturing Creativity using IdeaGraph 92 4.5 Research Framework 93 4.5.1 Step 1. Pre-Analysis: Data Preparation 94 4.5.1.1 Target Technology Selection 94 4.5.1.2 Data Acquisition 95 4.5.1.3 Data Preprocessing 95 4.5.2 Step 2. Text Analysis: Scenario Building 96 4.5.2.1 General Glimpse using Overt Structures 96 4.5.2.2 Hidden Details using Latent Structures 98 4.5.3 Step 3. Post-Analysis: Analytical Interpretation 101 4.5.3.1 Individual Impact Scenario 101 4.5.3.2 Overall Latent Impacts 101 4.6 Illustrative Case Study: 3D Printing Technology 102 4.7 Discussion 110 4.7.1 Scenarios Beyond the Obvious 110 4.7.2 Comparative Analysis 113 4.8 Conclusion 115 Chapter 5 Foresight for Plan Development 117 5.1 Introduction 118 5.2 Theoretical Paradigm Shift 120 5.2.1 Technology-focused vs. Society-focused 120 5.2.2 Co-evolution of Technology and Society 122 5.2.3 Responsible Development 125 5.3 Methodological Paradigm Shift 127 5.3.1 Participatory Approach 127 5.3.2 Data-driven Approach 129 5.4 Rationale for using LSA 131 5.5 Research Framework 132 5.5.1 Step 1. Envisioning Social Issues 133 5.5.1.1 Collection of Future-oriented Web Data 133 5.5.1.2 Construction of Impact Scenarios 135 5.5.1.3 Conceptualization of Impact Scenarios 137 5.5.2 Step 2. Deriving Technical Solutions 138 5.5.2.1 Collection of Scientific Publication Data 138 5.5.2.2 Construction of Solution Concepts 139 5.6 Illustrative Case Study: Autonomous Vehicle 140 5.7 Discussion 149 5.7.1 Comparative Analysis 149 5.7.2 Major Strengths in Envisioning Social Impacts 152 5.7.3 Major Strengths in Overviewing Solutions 154 5.8 Conclusion 156 Chapter 6 Foresight for Technology Ideation 158 6.1 Introduction 159 6.2 Related Studies 161 6.2.1 Generating Creative Ideas 161 6.2.2 Data-driven Morphological Analysis 163 6.3 Technology Foresight using Wikipedia 165 6.3.1 Wikipedia as a Good Remedy 165 6.3.2 Preliminaries: How to Apply Wikipedia 168 6.4 Research Framework 173 6.4.1 Basic Model 174 6.4.2 Extended Model 175 6.4.2.1 Phase 1: Preliminary Phase 177 6.4.2.2 Phase 2: Dimension Development Phase 177 6.4.2.3 Phase 3: Value Development Phase 179 6.4.2.4 Phase 4: Sub-dimension Development Phase 182 6.5 Illustrative Case Study: Drone Technology 183 6.5.1 Basic Model 183 6.5.2 Extended Model 185 6.6 Comparative Analysis 193 6.6.1 Experimental Setup 193 6.6.2 Comparison of Results 195 6.7 Intrinsic Limitations of Applying Wikipedia 199 6.8 Conclusion 201 Chapter 7 Concluding Remarks 203 Bibliography 211 Appendix 236 Appendix A Result of overt and latent structures of each impact scenario 236 Appendix B Result of Wikipedia-based morphological matrix (basic model) 240 Appendix C Result of Wikipedia-based morphological matrix using superordinate seed terms (extended model) 241 Appendix D Result of Wikipedia-based morphological matrix after applying subordinate value seed terms (extended model) 243 Appendix E Result of Wikipedia-based morphological matrix after developing sub-dimensions (extended model) 247Docto

Plasmonics and its Applications

Plasmonics is a rapidly developing field that combines fundamental research and applications ranging from areas such as physics to engineering, chemistry, biology, medicine, food sciences, and the environmental sciences. Plasmonics appeared in the 1950s with the discovery of surface plasmon polaritons. Plasmonics then went through a novel propulsion in the mid-1970s, when surface-enhanced Raman scattering was discovered. Nevertheless, it is in this last decade that a very significant explosion of plasmonics and its applications has occurred. Thus, this book provides a snapshot of the current advances in these various areas of plasmonics and its applications, such as engineering, sensing, surface-enhanced fluorescence, catalysis, and photovoltaic devices

NIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

The extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...postprin

Amphiphilic Anionic Pt(II) Complexes: from spectroscopic to morphological changes

A new class of amphiphilic anionic platinum(II) bzimpy complexes has been demonstrated to show aggregation in water through PtfflfflfflPt and π–π stacking interactions. An interesting aggregation–partial deaggregation–aggregation process and a morphological transformation from vesicles to nanofibers have been demonstrated. These changes can be systematically controlled by the variation of solvent composition and could readily be probed by UV-vis absorption, emission, NMR, transmission electron microscopy and even with our naked eyes ...postprin

Induced self-assembly and Förster Resonance Energy Transfer Studies of Alkynylplatinum(II) Terpyridine Complex through interaction with water-soluble Poly(phenylene ethynylene sulfonate) and the proof-of-principle demonstration of this two-component ensemble for selective label-free detection of Human Serum Albumin (HSA)

The interaction of conjugated polyelectrolyte, PPE-SO3−, with platinum(II) complexes, [Pt(tpy)(C≡CC6H4CH2NMe3-4)](OTf)2 (1) and [Pt(tpy)(C≡C–CH2NMe3)](OTf)2 (2), has been studied by UV–vis, and steady-state and time-resolved emission spectroscopy. A unique FRET from PPE-SO3−to the aggregated complex 1on the polymer chain with PtfflfflfflPt interactionhas been demonstrated, resulting in the growth of triplet metal-metal-to-ligand charge transfer (3MMLCT) emission ...postprin

Engineering derivatives from biological systems for advanced aerospace applications

The present study consisted of a literature survey, a survey of researchers, and a workshop on bionics. These tasks produced an extensive annotated bibliography of bionics research (282 citations), a directory of bionics researchers, and a workshop report on specific bionics research topics applicable to space technology. These deliverables are included as Appendix A, Appendix B, and Section 5.0, respectively. To provide organization to this highly interdisciplinary field and to serve as a guide for interested researchers, we have also prepared a taxonomy or classification of the various subelements of natural engineering systems. Finally, we have synthesized the results of the various components of this study into a discussion of the most promising opportunities for accelerated research, seeking solutions which apply engineering principles from natural systems to advanced aerospace problems. A discussion of opportunities within the areas of materials, structures, sensors, information processing, robotics, autonomous systems, life support systems, and aeronautics is given. Following the conclusions are six discipline summaries that highlight the potential benefits of research in these areas for NASA's space technology programs