Towards Integration of Artificial Intelligence into Medical Devices as a Real-Time Recommender System for Personalised Healthcare:State-of-the-Art and Future Prospects

In the era of big data, artificial intelligence (AI) algorithms have the potential to revolutionize healthcare by improving patient outcomes and reducing healthcare costs. AI algorithms have frequently been used in health care for predictive modelling, image analysis and drug discovery. Moreover, as a recommender system, these algorithms have shown promising impacts on personalized healthcare provision. A recommender system learns the behaviour of the user and predicts their current preferences (recommends) based on their previous preferences. Implementing AI as a recommender system improves this prediction accuracy and solves cold start and data sparsity problems. However, most of the methods and algorithms are tested in a simulated setting which cannot recapitulate the influencing factors of the real world. This review article systematically reviews prevailing methodologies in recommender systems and discusses the AI algorithms as recommender systems specifically in the field of healthcare. It also provides discussion around the most cutting-edge academic and practical contributions present in the literature, identifies performance evaluation matrices, challenges in the implementation of AI as a recommender system, and acceptance of AI-based recommender systems by clinicians. The findings of this article direct researchers and professionals to comprehend currently developed recommender systems and the future of medical devices integrated with real-time recommender systems for personalized healthcare

Advances in transfer learning methods based on computational intelligence

Traditional machine learning and data mining have made tremendous progress in many knowledge-based areas, such as clustering, classification, and regression. However, the primary assumption in all of these areas is that the training and testing data should be in the same domain and have the same distribution. This assumption is difficult to achieve in real-world applications due to the limited availability of labeled data. Associated data in different domains can be used to expand the availability of prior knowledge about future target data. In recent years, transfer learning has been used to address such cross-domain learning problems by using information from data in a related domain and transferring that data to the target task. The transfer learning methodology is utilized in this work with unsupervised and supervised learning methods. For unsupervised learning, a novel transfer-learning possibilistic c-means (TLPCM) algorithm is proposed to handle the PCM clustering problem in a domain that has insufficient data. Moreover, TLPCM overcomes the problem of differing numbers of clusters between the source and target domains. The proposed algorithm employs the historical cluster centers of the source data as a reference to guide the clustering of the target data. The experimental studies presented here were thoroughly evaluated, and they demonstrate the advantages of TLPCM in both synthetic and real-world transfer datasets. For supervised learning, a transfer learning (TL) technique is used to pre-train a CNN model on posture data and then fine-tune it on the sleep stage data. We used a ballistocardiography (BCG) bed sensor to collect both posture and sleep stage data to provide a non-invasive, in-home monitoring system that tracks changes in the subjects' health over time. The quality of sleep has a significant impact on health and life. This study adopts a hierarchical and none-hierarchical classification structure to develop an automatic sleep stage classification system using ballistocardiogram (BCG) signals. A leave-one-subject-out cross-validation (LOSO-CV) procedure is used for testing classification performance in most of the experiments. Convolutional Neural Networks (CNNs), Long Short-Term Memory (LSTM), and Deep Neural Networks DNNs are complementary in their modeling capabilities, while CNNs have the advantage of reducing frequency variations, LSTMs are good at temporal modeling. Polysomnography (PSG) data from a sleep lab was used as the ground truth for sleep stages, with the emphasis on three sleep stages, specifically, awake, rapid eye movement (REM), and non-REM sleep (NREM). Moreover, a transfer learning approach is employed with supervised learning to address the cross-resident training problem to predict early illness. We validate our method by conducting a retrospective study on three residents from TigerPlace, a retirement community in Columbia, MO, where apartments are fitted with wireless networks of motion and bed sensors. Predicting the early signs of illness in older adults by using a continuous, unobtrusive nursing home monitoring system has been shown to increase the quality of life and decrease care costs. Illness prediction is based on sensor data and uses algorithms such as support vector machine (SVM) and k-nearest neighbors (kNN). One of the most significant challenges related to the development of prediction algorithms for sensor networks is the use of knowledge from previous residents to predict new ones' behaviors. Each day, the presence or absence of illness was manually evaluated using nursing visit reports from a homegrown electronic medical record (EMR) system. In this work, the transfer learning SVM approach outperformed three other methods, i.e., regular SVM, one-class SVM, and one-class kNN.Includes bibliographical references (pages 114-127)

Social analytics for health integration, intelligence, and monitoring

Nowadays, patient-generated social health data are abundant and Healthcare is changing from the authoritative provider-centric model to collaborative and patient-oriented care. The aim of this dissertation is to provide a Social Health Analytics framework to utilize social data to solve the interdisciplinary research challenges of Big Data Science and Health Informatics. Specific research issues and objectives are described below. The first objective is semantic integration of heterogeneous health data sources, which can vary from structured to unstructured and include patient-generated social data as well as authoritative data. An information seeker has to spend time selecting information from many websites and integrating it into a coherent mental model. An integrated health data model is designed to allow accommodating data features from different sources. The model utilizes semantic linked data for lightweight integration and allows a set of analytics and inferences over data sources. A prototype analytical and reasoning tool called “Social InfoButtons” that can be linked from existing EHR systems is developed to allow doctors to understand and take into consideration the behaviors, patterns or trends of patients’ healthcare practices during a patient’s care. The tool can also shed insights for public health officials to make better-informed policy decisions. The second objective is near-real time monitoring of disease outbreaks using social media. The research for epidemics detection based on search query terms entered by millions of users is limited by the fact that query terms are not easily accessible by non-affiliated researchers. Publically available Twitter data is exploited to develop the Epidemics Outbreak and Spread Detection System (EOSDS). EOSDS provides four visual analytics tools for monitoring epidemics, i.e., Instance Map, Distribution Map, Filter Map, and Sentiment Trend to investigate public health threats in space and time. The third objective is to capture, analyze and quantify public health concerns through sentiment classifications on Twitter data. For traditional public health surveillance systems, it is hard to detect and monitor health related concerns and changes in public attitudes to health-related issues, due to their expenses and significant time delays. A two-step sentiment classification model is built to measure the concern. In the first step, Personal tweets are distinguished from Non-Personal tweets. In the second step, Personal Negative tweets are further separated from Personal Non-Negative tweets. In the proposed classification, training data is labeled by an emotion-oriented, clue-based method, and three Machine Learning models are trained and tested. Measure of Concern (MOC) is computed based on the number of Personal Negative sentiment tweets. A timeline trend of the MOC is also generated to monitor public concern levels, which is important for health emergency resource allocations and policy making. The fourth objective is predicting medical condition incidence and progression trajectories by using patients’ self-reported data on PatientsLikeMe. Some medical conditions are correlated with each other to a measureable degree (“comorbidities”). A prediction model is provided to predict the comorbidities and rank future conditions by their likelihood and to predict the possible progression trajectories given an observed medical condition. The novel models for trajectory prediction of medical conditions are validated to cover the comorbidities reported in the medical literature

Wearables at work:preferences from an employee’s perspective

This exploratory study aims to obtain a first impression of the wishes and needs of employees on the use of wearables at work for health promotion. 76 employ-ees with a mean age of 40 years old (SD ±11.7) filled in a survey after trying out a wearable. Most employees see the potential of using wearable devices for workplace health promotion. However, according to employees, some negative aspects should be overcome before wearables can effectively contribute to health promotion. The most mentioned negative aspects were poor visualization and un-pleasantness of wearing. Specifically for the workplace, employees were con-cerned about the privacy of data collection

Computational Sleep Science: Machine Learning for the Detection, Diagnosis, and Treatment of Sleep Problems from Wearable Device Data

University of Minnesota Ph.D. dissertation.December 2017. Major: Computer Science. Advisor: Jaideep Srivastava. 1 computer file (PDF); xiii, 122 pages.This thesis is motivated by the rapid increase in global life expectancy without the respective improvements in quality of life. I propose several novel machine learning and data mining methodologies for approaching a paramount component of quality of life, the translational science field of sleep research. Inadequate sleep negatively affects both mental and physical well-being, and exacerbates many non-communicable health problems such as diabetes, depression, cancer and obesity. Taking advantage of the ubiquitous adoption of wearable devices, I create algorithmic solutions to analyse sensor data. The goal is to improve the quality of life of wearable device users, as well as provide clinical insights and tools for sleep researchers and care-providers. Chapter 1 is the introduction. This section substantiates the timely relevance of sleep research for today's society, and its contribution towards improved global health. It covers the history of sleep science technology and identifies core computing challenges in the field. The scope of the thesis is established and an approach is articulated. Useful definitions, sleep domain terminology, and some pre-processing steps are defined. Lastly, an outline for the remainder of the thesis is included. Chapter 2 dives into my proposed methodology for widespread screening of sleep disorders. It surveys results from the application of several statistical and data mining methods. It also introduces my novel deep learning architecture optimized for the unique dimensionality and nature of wearable device data. Chapter 3 focuses on the diagnosis stage of the sleep science process. I introduce a human activity recognition algorithm called RAHAR, Robust Automated Human Activity Recognition. This algorithm is unique in a number of ways, including its objective of annotating a behavioural time series with exertion levels rather than activity type. Chapter 4 focuses on the last step of the sleep science process, therapy. I define a pipeline to identify \textit{behavioural recipes}. These \textit{recipes} are the target behaviour that a user should complete in order to have good quality sleep. This work provides the foundation for building out a dynamic real-time recommender system for wearable device users, or a clinically administered cognitive behavioural therapy program. Chapter 5 summarizes the impact of this body of work, and takes a look into next steps. This chapter concludes my thesis

Diagnosis and Prognosis of Occupational disorders based on Machine Learn- ing Techniques applied to Occupational Profiles

Work-related disorders have a global influence on people’s well-being and quality of life and are a financial burden for organizations because they reduce productivity, increase absenteeism, and promote early retirement. Work-related musculoskeletal disorders, in particular, represent a significant fraction of the total in all occupational contexts. In automotive and industrial settings where workers are exposed to work-related muscu- loskeletal disorders risk factors, occupational physicians are responsible for monitoring workers’ health protection profiles. Occupational technicians report in the Occupational Health Protection Profiles database to understand which exposure to occupational work- related musculoskeletal disorder risk factors should be ensured for a given worker. Occu- pational Health Protection Profiles databases describe the occupational physician states, and which exposure the physicians considers necessary to ensure the worker’s health protection in terms of their functional work ability. The application of Human-Centered explainable artificial intelligence can support the decision making to go from worker’s Functional Work Ability to explanations by integrating explainability into medical (re- striction) and supporting in two decision contexts: prognosis and diagnosis of individual, work related and organizational risk condition. Although previous machine learning ap- proaches provided good predictions, their application in an actual occupational setting is limited because their predictions are difficult to interpret and hence, not actionable. In this thesis, injured body parts in which the ability changed in a worker’s functional work ability status are targeted. On the one hand, artificial intelligence algorithms can help technical teams, occupational physicians, and ergonomists determine a worker’s workplace risk via the diagnosis and prognosis of body part(s) injuries; on the other hand, these approaches can help prevent work-related musculoskeletal disorders by identifying which processes are lacking in working condition improvement and which workplaces have a better match between the remaining functional work abilities. A sample of 2025 for the prognosis part (from the years of 2019 to 2020) and 7857 for the prognosis part of Occupational Health Protection Profiles based on Functional Work Ability textual re- ports in the Portuguese language in automotive industry factory. Machine learning-based Natural Language Processing methods were implemented to extract standardized infor- mation. The prognosis and diagnosis of Occupational Health Protection Profiles factors were developed in reliable Human-Centered explainable artificial intelligence system to promote a trustworthy Human-Centered explainable artificial intelligence system (enti- tled Industrial microErgo application). The most suitable regression models to predict the next medical appointment for the injured body regions were the models based on CatBoost regression, with R square and an RMSLE of 0.84 and 1.23 weeks, respectively. In parallel, CatBoost’s best regression model for most body parts is the prediction of the next injured body parts based on these two errors. This information can help tech- nical industrial teams understand potential risk factors for Occupational Health Protec- tion Profiles and identify warning signs of the early stages of musculoskeletal disorders.Os transtornos relacionados ao trabalho têm influência global no bem-estar e na quali- dade de vida das pessoas e são um ônus financeiro para as organizações, pois reduzem a produtividade, aumentam o absenteísmo e promovem a aposentadoria precoce. Os distúr- bios osteomusculares relacionados ao trabalho, em particular, representam uma fração significativa do total em todos os contextos ocupacionais. Em ambientes automotivos e industriais onde os trabalhadores estão expostos a fatores de risco de distúrbios osteomus- culares relacionados ao trabalho, os médicos do trabalho são responsáveis por monitorar os perfis de proteção à saúde dos trabalhadores. Os técnicos do trabalho reportam-se à base de dados dos Perfis de Proteção da Saúde Ocupacional para compreender quais os fatores de risco de exposição a perturbações músculo-esqueléticas relacionadas com o tra- balho que devem ser assegurados para um determinado trabalhador. As bases de dados de Perfis de Proteção à Saúde Ocupacional descrevem os estados do médico do trabalho e quais exposições os médicos consideram necessária para garantir a proteção da saúde do trabalhador em termos de sua capacidade funcional para o trabalho. A aplicação da inteligência artificial explicável centrada no ser humano pode apoiar a tomada de decisão para ir da capacidade funcional de trabalho do trabalhador às explicações, integrando a explicabilidade à médica (restrição) e apoiando em dois contextos de decisão: prognóstico e diagnóstico da condição de risco individual, relacionado ao trabalho e organizacional . Embora as abordagens anteriores de aprendizado de máquina tenham fornecido boas pre- visões, sua aplicação em um ambiente ocupacional real é limitada porque suas previsões são difíceis de interpretar e portanto, não acionável. Nesta tese, as partes do corpo lesiona- das nas quais a habilidade mudou no estado de capacidade funcional para o trabalho do trabalhador são visadas. Por um lado, os algoritmos de inteligência artificial podem aju- dar as equipes técnicas, médicos do trabalho e ergonomistas a determinar o risco no local de trabalho de um trabalhador por meio do diagnóstico e prognóstico de lesões em partes do corpo; por outro lado, essas abordagens podem ajudar a prevenir distúrbios muscu- loesqueléticos relacionados ao trabalho, identificando quais processos estão faltando na melhoria das condições de trabalho e quais locais de trabalho têm uma melhor correspon- dência entre as habilidades funcionais restantes do trabalho. Para esta tese, foi utilizada uma base de dados com Perfis de Proteção à Saúde Ocupacional, que se baseiam em relató- rios textuais de Aptidão para o Trabalho em língua portuguesa, de uma fábrica da indús- tria automóvel (Auto Europa). Uma amostra de 2025 ficheiros foi utilizada para a parte de prognóstico (de 2019 a 2020) e uma amostra de 7857 ficheiros foi utilizada para a parte de diagnóstico. . Aprendizado de máquina- métodos baseados em Processamento de Lingua- gem Natural foram implementados para extrair informações padronizadas. O prognóstico e diagnóstico dos fatores de Perfis de Proteção à Saúde Ocupacional foram desenvolvidos em um sistema confiável de inteligência artificial explicável centrado no ser humano (inti- tulado Industrial microErgo application). Os modelos de regressão mais adequados para prever a próxima consulta médica para as regiões do corpo lesionadas foram os modelos baseados na regressão CatBoost, com R quadrado e RMSLE de 0,84 e 1,23 semanas, res- pectivamente. Em paralelo, a previsão das próximas partes do corpo lesionadas com base nesses dois erros relatados pelo CatBoost como o melhor modelo de regressão para a mai- oria das partes do corpo. Essas informações podem ajudar as equipes técnicas industriais a entender os possíveis fatores de risco para os Perfis de Proteção à Saúde Ocupacio- nal e identificar sinais de alerta dos estágios iniciais de distúrbios musculoesqueléticos