Scientific and Technological Regimes in Nanotechnology: Combinatorial Inventors and Performance

Academics and policy makers are questioning about the relation between science and technology in the emerging field of nano science and technology (NST) and the effectiveness of different institutional regimes. We analyze the performance of inventors in the NST using multiple indicators. We clustered patents in three groups according to the scientific curricula of the inventors. The first two groups are composed by patents whose inventors respectively are all authors of at least one scientific publication in the NST and none of then has obtained a scientific publication in that field. Thirdly, we isolated those patents that have at least one inventor, who is also author of at least one scientific publication in the NST. The underlining presumption of this classification is that of a proxy of different institutional search regimes of the inventive activity; pure academic research, pure industrial R&D, and academic-industrial research partnerships.Science-Technology Relation, Emerging Field, Nanotechnology, Patent Quality, Inventive Productivity.

The effect of coronary calcifications on interpretation of non-invasive investigations for coronary artery disease in patients with typical chest pain

Coronary artery disease (CAD) is the most common cause of mortality. Invasive coronary angiography remains the gold standard for the diagnosis of patients with stable CAD and acute coronary syndromes (ACS). However, the accurate diagnosis of CAD is complex and may involve a number of different investigations, including non-invasive techniques, primarily based on patient symptoms. The aim of this thesis was to investigate the prediction of CAD from coronary calcium scoring using multi-detector computed tomography (MDCT) against exercise treadmill testing (ETT [n=360]), myocardial perfusion imaging using magnetic resonance imaging (CMR [n=120]), and myocardial ischaemia assessed using Dobutamine stress echocardiography (DSE [n=35]) in a retrospective cohort of patients with typical chest pain. All 515 patients underwent conventional coronary angiography within 1-month of their non-invasive investigations. The results of this thesis demonstrated that MDCT is more accurate than ETT in identifying significant CAD, whereas a negative ETT was accurate in excluding CAD, as such the two investigations are complementary. Compared to CMR, MDCT was more accurate in detecting significant CAD. However, the burden of perfusion defects during stress was associated with a progressive increase in CAC in patients with non-obstructive CAD only. Finally, DSE was abnormal in patients with non-significant coronary stenosis but with high CAC and a positive ETT, which may suggest microvascular disease. In addition, resting wall motion abnormalities on echocardiography was associated with coronary calcification by MDCT. Non-invasive techniques for the assessment, diagnosis and treatment of CAD remains an integral component for the investigation of chest pain. Future research is required to investigate the relative importance of non-invasive assessments of CAD with respect to coronary intervention, adverse cardiovascular outcomes and all-cause mortality

THE USE OF THE MULTI-FACTORIAL GRID IN THE SELECTION OF THE ENTRY STRATEGIES OF OMV AG IN THE ROMANIAN MARKET

The foreign market entry is a strategic choice of any company. The firms use a practical approach in order to select and utilize the most appropriate market entry strategies and modes. This paper aims at showing how the multi-factorial grid can check up ttarget-market, entry strategies and modes, multi-factorial grid, competition capability of the company, market attractiveness

The Growth of Industrial Sectors: Theoretical Insights and Empirical Evidence from U.S. Manufacturing

In this paper, we study the growth rates of 4-digit sectors in U.S. manufacturing. Two measures of size (value of shipments, value added) are considered, for each of the 38 years (1959-1996) of a sample of 458 4-digit sectors, drawn from the NBER Manufacturing Productivity database. Whole sample results are partly in line with firm growth facts: (i) sectoral growth rates are distributed according to heavy-tailed Subbotin distributions, with shape coefficient between 1.0 (Laplace) and 1.5; (ii) the volatility of growth rates is decreasing with respect to size, with a scaling exponent varying over time, but always between -0.20 and -0.10. Preliminary analyses on more homogeneous groups cast doubts on the evidence of scaling, but leave basically unaffected the distributional properties of sectoral growth. These results shed light on the role of inter-firm correlations, market concentration, and positive intersectoral feedbacks as drivers of meso-economic dynamics.Sectoral Growth, Subbotin Distribution, Scaling, U.S. Manufacturing

Modelling credit risk for innovative firms: the role of innovation measures

Financial constraints are particularly severe for R&D projects of SMEs, which cannot generally rely on equity markets and, in the EU, on a sufficiently developed VC industry. If innovative SMEs have to depend on banks to finance their R&D projects, it is particularly important to develop models able to estimate their probability of default (PD) in consideration of their peculiar features. Based on the signaling value of some innovative assets, the purpose of this paper is to show the importance to include them into models which have proved to be successful for SMEs. To this end, we take a logit model and test it on a unique dataset of innovative SMEs (based on PATSTAT database, EPO BULLETIN and AMADEUS) to estimate a two-year PD with default years 2006-2008. In the regression analysis the innovation-related variables are two in order to account for R&D productivity at the level of the firm and to consider the value of the inventive output. Our analyses first address measurement issues concerning innovation-related variable and then show that, while the accounting variables and the patent value are always significant with the expected sign, the patent number per se reduces the PD only in the presence of an appropriate equity level.innovative SMEs; default probability; patent value

Financial Patenting in Europe

We take a first look at financial patents at the European Patent Office (EPO). As is the case at the US Patent and Trademark Office (USPTO), the number of financial patents in Europe has increased significantly in parallel with significant changes in payment and financial systems. Scholars have argued that financial patents, like other business methods patents, have low value and are owned for strategic reasons rather than for protecting real inventions. We find that established firms in non-financial sectors with diversified patent portfolios own a large share of financial patents at the EPO. However, new specialized technology providers in the financial area also hold a number of such patents. Decisions on the financial patent applications take longer and they are more likely to be refused by the patent office, suggesting greater uncertainty over validity than for other patents. They are also more likely to be opposed, which is consistent with the fact that their other economic value indicators are higher.market valuation, intangible assets, patents, software, Europe

Introducing risk management into the grid

Service Level Agreements (SLAs) are explicit statements about all expectations and obligations in the business partnership between customers and providers. They have been introduced in Grid computing to overcome the best effort approach, making the Grid more interesting for commercial applications. However, decisions on negotiation and system management still rely on static approaches, not reflecting the risk linked with decisions. The EC-funded project "AssessGrid" aims at introducing risk assessment and management as a novel decision paradigm into Grid computing. This paper gives a general motivation for risk management and presents the envisaged architecture of a "risk-aware" Grid middleware and Grid fabric, highlighting its functionality by means of three showcase scenarios

MAGDA: A Mobile Agent based Grid Architecture

Mobile agents mean both a technology and a programming paradigm. They allow for a flexible approach which can alleviate a number of issues present in distributed and Grid-based systems, by means of features such as migration, cloning, messaging and other provided mechanisms. In this paper we describe an architecture (MAGDA – Mobile Agent based Grid Architecture) we have designed and we are currently developing to support programming and execution of mobile agent based application upon Grid systems

IVOA Recommendation: IVOA Support Interfaces

This document describes the minimum interface that a (SOAP- or REST-based) web service requires to participate in the IVOA. Note that this is not required of standard VO services developed prior to this specification, although uptake is strongly encouraged on any subsequent revision. All new standard VO services, however, must feature a VOSI-compliant interface. This document has been produced by the Grid and Web Services Working Group. It has been reviewed by IVOA Members and other interested parties, and has been endorsed by the IVOA Executive Committee as an IVOA Recommendation. It is a stable document and may be used as reference material or cited as a normative reference from another document. IVOA's role in making the Recommendation is to draw attention to the specification and to promote its widespread deployment. This enhances the functionality and interoperability inside the Astronomical Community