10,231 research outputs found
Turbo-FLASH based arterial spin labeled perfusion MRI at 7 T.
Motivations of arterial spin labeling (ASL) at ultrahigh magnetic fields include prolonged blood T1 and greater signal-to-noise ratio (SNR). However, increased B0 and B1 inhomogeneities and increased specific absorption ratio (SAR) challenge practical ASL implementations. In this study, Turbo-FLASH (Fast Low Angle Shot) based pulsed and pseudo-continuous ASL sequences were performed at 7T, by taking advantage of the relatively low SAR and short TE of Turbo-FLASH that minimizes susceptibility artifacts. Consistent with theoretical predictions, the experimental data showed that Turbo-FLASH based ASL yielded approximately 4 times SNR gain at 7T compared to 3T. High quality perfusion images were obtained with an in-plane spatial resolution of 0.85×1.7 mm(2). A further functional MRI study of motor cortex activation precisely located the primary motor cortex to the precentral gyrus, with the same high spatial resolution. Finally, functional connectivity between left and right motor cortices as well as supplemental motor area were demonstrated using resting state perfusion images. Turbo-FLASH based ASL is a promising approach for perfusion imaging at 7T, which could provide novel approaches to high spatiotemporal resolution fMRI and to investigate the functional connectivity of brain networks at ultrahigh field
Hybrid apparatus for Bose-Einstein condensation and cavity quantum electrodynamics: Single atom detection in quantum degenerate gases
We present and characterize an experimental system in which we achieve the
integration of an ultrahigh finesse optical cavity with a Bose-Einstein
condensate (BEC). The conceptually novel design of the apparatus for the
production of BECs features nested vacuum chambers and an in-vacuo magnetic
transport configuration. It grants large scale spatial access to the BEC for
samples and probes via a modular and exchangeable "science platform". We are
able to produce \87Rb condensates of five million atoms and to output couple
continuous atom lasers. The cavity is mounted on the science platform on top of
a vibration isolation system. The optical cavity works in the strong coupling
regime of cavity quantum electrodynamics and serves as a quantum optical
detector for single atoms. This system enables us to study atom optics on a
single particle level and to further develop the field of quantum atom optics.
We describe the technological modules and the operation of the combined BEC
cavity apparatus. Its performance is characterized by single atom detection
measurements for thermal and quantum degenerate atomic beams. The atom laser
provides a fast and controllable supply of atoms coupling with the cavity mode
and allows for an efficient study of atom field interactions in the strong
coupling regime. Moreover, the high detection efficiency for quantum degenerate
atoms distinguishes the cavity as a sensitive and weakly invasive probe for
cold atomic clouds
Ultrahigh field electron cyclotron resonance absorption in InMnAs films
We have carried out an ultrahigh field cyclotron resonance study of -type
InMnAs films, with Mn composition ranging from 0 to 12%, grown
on GaAs by low temperature molecular beam epitaxy. We observe that the electron
cyclotron resonance peak shifts to lower field with increasing . A detailed
comparison of experimental results with calculations based on a modified
Pidgeon-Brown model allows us to estimate the {\em s-d} and {\em p-d} exchange
coupling constants, and , for this important III-V dilute
magnetic semiconductor system.Comment: 4 pages, 4 figure
Reconfigurable quantum metamaterials
By coupling controllable quantum systems into larger structures we introduce
the concept of a quantum metamaterial. Conventional meta-materials represent
one of the most important frontiers in optical design, with applications in
diverse fields ranging from medicine to aerospace. Up until now however,
metamaterials have themselves been classical structures and interact only with
the classical properties of light. Here we describe a class of dynamic
metamaterials, based on the quantum properties of coupled atom-cavity arrays,
which are intrinsically lossless, reconfigurable, and operate fundamentally at
the quantum level. We show how this new class of metamaterial could be used to
create a reconfigurable quantum superlens possessing a negative index gradient
for single photon imaging. With the inherent features of quantum superposition
and entanglement of metamaterial properties, this new class of dynamic quantum
metamaterial, opens a new vista for quantum science and technology.Comment: 16 pages, 8 figure
Axon diameters and myelin content modulate microscopic fractional anisotropy at short diffusion times in fixed rat spinal cord
Mapping tissue microstructure accurately and noninvasively is one of the
frontiers of biomedical imaging. Diffusion Magnetic Resonance Imaging (MRI) is
at the forefront of such efforts, as it is capable of reporting on microscopic
structures orders of magnitude smaller than the voxel size by probing
restricted diffusion. Double Diffusion Encoding (DDE) and Double Oscillating
Diffusion Encoding (DODE) in particular, are highly promising for their ability
to report on microscopic fractional anisotropy ({\mu}FA), a measure of the pore
anisotropy in its own eigenframe, irrespective of orientation distribution.
However, the underlying correlates of {\mu}FA have insofar not been studied.
Here, we extract {\mu}FA from DDE and DODE measurements at ultrahigh magnetic
field of 16.4T in the aim to probe fixed rat spinal cord microstructure. We
further endeavor to correlate {\mu}FA with Myelin Water Fraction (MWF) derived
from multiexponential T2 relaxometry, as well as with literature-based
spatially varying axonal diameters. In addition, a simple new method is
presented for extracting unbiased {\mu}FA from three measurements at different
b-values. Our findings reveal strong anticorrelations between {\mu}FA (derived
from DODE) and axon diameter in the distinct spinal cord tracts; a moderate
correlation was also observed between {\mu}FA derived from DODE and MWF. These
findings suggest that axonal membranes strongly modulate {\mu}FA, which - owing
to its robustness towards orientation dispersion effects - reflects axon
diameter much better than its typical FA counterpart. The {\mu}FA exhibited
modulations when measured via oscillating or blocked gradients, suggesting
selective probing of different parallel path lengths and providing insight into
how those modulate {\mu}FA metrics. Our findings thus shed light into the
underlying microstructural correlates of {\mu}FA and are (...
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