Selecting cash management models from a multiobjective perspective

[EN] This paper addresses the problem of selecting cash management models under different operating conditions from a multiobjective perspective considering not only cost but also risk. A number of models have been proposed to optimize corporate cash management policies. The impact on model performance of different operating conditions becomes an important issue. Here, we provide a range of visual and quantitative tools imported from Receiver Operating Characteristic (ROC) analysis. More precisely, we show the utility of ROC analysis from a triple perspective as a tool for: (1) showing model performance; (2) choosingmodels; and (3) assessing the impact of operating conditions on model performance. We illustrate the selection of cash management models by means of a numerical example.Work partially funded by projects Collectiveware TIN2015-66863-C2-1-R (MINECO/FEDER) and 2014 SGR 118.Salas-Molina, F.; Rodríguez-Aguilar, JA.; Díaz-García, P. (2018). 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QuantiMus: A Machine Learning-Based Approach for High Precision Analysis of Skeletal Muscle Morphology.

Skeletal muscle injury provokes a regenerative response, characterized by the de novo generation of myofibers that are distinguished by central nucleation and re-expression of developmentally restricted genes. In addition to these characteristics, myofiber cross-sectional area (CSA) is widely used to evaluate muscle hypertrophic and regenerative responses. Here, we introduce QuantiMus, a free software program that uses machine learning algorithms to quantify muscle morphology and molecular features with high precision and quick processing-time. The ability of QuantiMus to define and measure myofibers was compared to manual measurement or other automated software programs. QuantiMus rapidly and accurately defined total myofibers and measured CSA with comparable performance but quantified the CSA of centrally-nucleated fibers (CNFs) with greater precision compared to other software. It additionally quantified the fluorescence intensity of individual myofibers of human and mouse muscle, which was used to assess the distribution of myofiber type, based on the myosin heavy chain isoform that was expressed. Furthermore, analysis of entire quadriceps cross-sections of healthy and mdx mice showed that dystrophic muscle had an increased frequency of Evans blue dye+ injured myofibers. QuantiMus also revealed that the proportion of centrally nucleated, regenerating myofibers that express embryonic myosin heavy chain (eMyHC) or neural cell adhesion molecule (NCAM) were increased in dystrophic mice. Our findings reveal that QuantiMus has several advantages over existing software. The unique self-learning capacity of the machine learning algorithms provides superior accuracy and the ability to rapidly interrogate the complete muscle section. These qualities increase rigor and reproducibility by avoiding methods that rely on the sampling of representative areas of a section. This is of particular importance for the analysis of dystrophic muscle given the "patchy" distribution of muscle pathology. QuantiMus is an open source tool, allowing customization to meet investigator-specific needs and provides novel analytical approaches for quantifying muscle morphology

A cognitive architecture for learning in reactive environments

Previous research in machine learning has viewed the process of empirical discovery as search through a space of 'theoretical' terms. In this paper, we propose a problem space for empirical discovery, specifying six complementary operators for defining new terms that ease the statement of empirical laws. The six types of terms include: numeric attributes (such as PV/T); intrinsic properties (such as mass); composite objects (such as pairs of colliding balls); classes of objects (such as acids and alkalis); composite relations (such as chemical reactions); and classes of relations (such as combustion/oxidation). We review existing machine discovery systems in light of this framework, examining which parts of the problem space were, covered by these systems. Finally, we outline an integrated discovery system (IDS) we are constructing that includes all six of the operators and which should be able to discover a broad range of empirical laws

On the automated extraction of regression knowledge from databases

The advent of inexpensive, powerful computing systems, together with the increasing amount of available data, conforms one of the greatest challenges for next-century information science. Since it is apparent that much future analysis will be done automatically, a good deal of attention has been paid recently to the implementation of ideas and/or the adaptation of systems originally developed in machine learning and other computer science areas. This interest seems to stem from both the suspicion that traditional techniques are not well-suited for large-scale automation and the success of new algorithmic concepts in difficult optimization problems. In this paper, I discuss a number of issues concerning the automated extraction of regression knowledge from databases. By regression knowledge is meant quantitative knowledge about the relationship between a vector of predictors or independent variables (x) and a scalar response or dependent variable (y). A number of difficulties found in some well-known tools are pointed out, and a flexible framework avoiding many such difficulties is described and advocated. Basic features of a new tool pursuing this direction are reviewed

A framework for empirical discovery

Previous research in machine learning has viewed the process of empirical discovery as search through a space of 'theoretical' terms. In this paper, we propose a problem space for empirical discovery, specifying six complementary operators for defining new terms that ease the statement of empirical laws. The six types of terms include: numeric attributes (such as PV/T); intrinsic properties (such as mass); composite objects (such as pairs of colliding balls); classes of objects (such as acids and alkalis); composite relations (such as chemical reactions); and classes of relations (such as combustion/oxidation). We review existing machine discovery systems in light of this framework, examining which parts of the problem space were, covered by these systems. Finally, we outline an integrated discovery system (IDS) we are constructing that includes all six of the operators and which should be able to discover a broad range of empirical laws

AI Education Matters: Lessons from a Kaggle Click-Through Rate Prediction Competition

In this column, we will look at a particular Kaggle.com click-through rate (CTR) prediction competition, observe what the winning entries teach about this part of the machine learning landscape, and then discuss the valuable opportunities and resources this commends to AI educators and their students. [excerpt