The advent of inexpensive, powerful computing systems, together with the increasing amount of available data, conforms one of the greatest challenges for next-century information science. Since it is apparent that much future analysis will be done automatically, a good deal of attention has been paid recently to the implementation of ideas and/or the adaptation of systems originally developed in machine learning and other computer science areas. This interest seems to stem from both the suspicion that traditional techniques are not well-suited for large-scale automation and the success of new algorithmic concepts in difficult optimization problems. In this paper, I discuss a number of issues concerning the automated extraction of regression knowledge from databases. By regression knowledge is meant quantitative knowledge about the relationship between a vector of predictors or independent variables (x) and a scalar response or dependent variable (y). A number of difficulties found in some well-known tools are pointed out, and a flexible framework avoiding many such difficulties is described and advocated. Basic features of a new tool pursuing this direction are reviewed
