216,711 research outputs found
Qualitative System Identification from Imperfect Data
Experience in the physical sciences suggests that the only realistic means of
understanding complex systems is through the use of mathematical models.
Typically, this has come to mean the identification of quantitative models
expressed as differential equations. Quantitative modelling works best when the
structure of the model (i.e., the form of the equations) is known; and the
primary concern is one of estimating the values of the parameters in the model.
For complex biological systems, the model-structure is rarely known and the
modeler has to deal with both model-identification and parameter-estimation. In
this paper we are concerned with providing automated assistance to the first of
these problems. Specifically, we examine the identification by machine of the
structural relationships between experimentally observed variables. These
relationship will be expressed in the form of qualitative abstractions of a
quantitative model. Such qualitative models may not only provide clues to the
precise quantitative model, but also assist in understanding the essence of
that model. Our position in this paper is that background knowledge
incorporating system modelling principles can be used to constrain effectively
the set of good qualitative models. Utilising the model-identification
framework provided by Inductive Logic Programming (ILP) we present empirical
support for this position using a series of increasingly complex artificial
datasets. The results are obtained with qualitative and quantitative data
subject to varying amounts of noise and different degrees of sparsity. The
results also point to the presence of a set of qualitative states, which we
term kernel subsets, that may be necessary for a qualitative model-learner to
learn correct models. We demonstrate scalability of the method to biological
system modelling by identification of the glycolysis metabolic pathway from
data
An immune network approach to learning qualitative models of biological pathways
ACKNOWLEDGMENT GMC is supported by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative. WP and GMC are also supported by the partnership fund from dot.rural, RCUK Digital Economy research.Postprin
Machine learning and its applications in reliability analysis systems
In this thesis, we are interested in exploring some aspects of Machine Learning (ML) and its application in the Reliability Analysis systems (RAs). We begin by investigating some ML paradigms and their- techniques, go on to discuss the possible applications of ML in improving RAs performance, and lastly give guidelines of the architecture of learning RAs. Our survey of ML covers both levels of Neural Network learning and Symbolic learning. In symbolic process learning, five types of learning and their applications are discussed: rote learning, learning from instruction, learning from analogy, learning from examples, and learning from observation and discovery. The Reliability Analysis systems (RAs) presented in this thesis are mainly designed for maintaining plant safety supported by two functions: risk analysis function, i.e., failure mode effect analysis (FMEA) ; and diagnosis function, i.e., real-time fault location (RTFL). Three approaches have been discussed in creating the RAs. According to the result of our survey, we suggest currently the best design of RAs is to embed model-based RAs, i.e., MORA (as software) in a neural network based computer system (as hardware). However, there are still some improvement which can be made through the applications of Machine Learning. By implanting the 'learning element', the MORA will become learning MORA (La MORA) system, a learning Reliability Analysis system with the power of automatic knowledge acquisition and inconsistency checking, and more. To conclude our thesis, we propose an architecture of La MORA
An integrative top-down and bottom-up qualitative model construction framework for exploration of biochemical systems
The authors would like to thank the support on this research by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer reviewedPublisher PD
Computational and Mathematical Modelling of the EGF Receptor System
This chapter gives an overview of computational and mathematical modelling of the EGF receptor system. It begins with a survey of motivations for producing such models, then describes the main approaches that are taken to carrying out such modelling, viz. differential equations and individual-based modelling. Finally, a number of projects that applying modelling and simulation techniques to various aspects of the EGF receptor system are described
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