DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of observed measures. Hidden Markov models (HMMs) and its variants are a class of models that both discover these states and make inferences of health states for patients. Despite the advantages of using the algorithms for discovering interesting patterns, it still remains challenging for medical experts to interpret model outputs, understand complex modeling parameters, and clinically make sense of the patterns. To tackle these problems, we conducted a design study with clinical scientists, statisticians, and visualization experts, with the goal to investigate disease progression pathways of chronic diseases, namely type 1 diabetes (T1D), Huntington's disease, Parkinson's disease, and chronic obstructive pulmonary disease (COPD). As a result, we introduce DPVis which seamlessly integrates model parameters and outcomes of HMMs into interpretable and interactive visualizations. In this study, we demonstrate that DPVis is successful in evaluating disease progression models, visually summarizing disease states, interactively exploring disease progression patterns, and building, analyzing, and comparing clinically relevant patient subgroups.Comment: to appear at IEEE Transactions on Visualization and Computer Graphic

Process Mining Workshops

This open access book constitutes revised selected papers from the International Workshops held at the Third International Conference on Process Mining, ICPM 2021, which took place in Eindhoven, The Netherlands, during October 31–November 4, 2021. The conference focuses on the area of process mining research and practice, including theory, algorithmic challenges, and applications. The co-located workshops provided a forum for novel research ideas. The 28 papers included in this volume were carefully reviewed and selected from 65 submissions. They stem from the following workshops: 2nd International Workshop on Event Data and Behavioral Analytics (EDBA) 2nd International Workshop on Leveraging Machine Learning in Process Mining (ML4PM) 2nd International Workshop on Streaming Analytics for Process Mining (SA4PM) 6th International Workshop on Process Querying, Manipulation, and Intelligence (PQMI) 4th International Workshop on Process-Oriented Data Science for Healthcare (PODS4H) 2nd International Workshop on Trust, Privacy, and Security in Process Analytics (TPSA) One survey paper on the results of the XES 2.0 Workshop is included

Implementation of an interactive pattern mining framework on electronic health record datasets

Large collections of electronic patient records contain a broad range of clinical information highly relevant for data analysis. However, they are maintained primarily for patient administration, and automated methods are required to extract valuable knowledge for predictive, preventive, personalized and participatory medicine. Sequential pattern mining is a fundamental task in data mining which can be used to find statistically relevant, non-trivial temporal dependencies of events such as disease comorbidities. This works objective is to use this mining technique to identify disease associations based on ICD-9-CM codes data of the entire Taiwanese population obtained from Taiwan’s National Health Insurance Research Database. This thesis reports the development and implementation of the Disease Pattern Miner – a pattern mining framework in a medical domain. The framework was designed as a Web application which can be used to run several state-of-the-art sequence mining algorithms on electronic health records, collect and filter the results to reduce the number of patterns to a meaningful size, and visualize the disease associations as an interactive model in a specific population group. This may be crucial to discover new disease associations and offer novel insights to explain disease pathogenesis. A structured evaluation of the data and models are required before medical data-scientist may use this application as a tool for further research to get a better understanding of disease comorbidities

Process Mining Workshops

This open access book constitutes revised selected papers from the International Workshops held at the Third International Conference on Process Mining, ICPM 2021, which took place in Eindhoven, The Netherlands, during October 31–November 4, 2021. The conference focuses on the area of process mining research and practice, including theory, algorithmic challenges, and applications. The co-located workshops provided a forum for novel research ideas. The 28 papers included in this volume were carefully reviewed and selected from 65 submissions. They stem from the following workshops: 2nd International Workshop on Event Data and Behavioral Analytics (EDBA) 2nd International Workshop on Leveraging Machine Learning in Process Mining (ML4PM) 2nd International Workshop on Streaming Analytics for Process Mining (SA4PM) 6th International Workshop on Process Querying, Manipulation, and Intelligence (PQMI) 4th International Workshop on Process-Oriented Data Science for Healthcare (PODS4H) 2nd International Workshop on Trust, Privacy, and Security in Process Analytics (TPSA) One survey paper on the results of the XES 2.0 Workshop is included

Facilitating the analysis of COVID-19 literature through a knowledge graph

At the end of 2019, Chinese authorities alerted the World Health Organization (WHO) of the outbreak of a new strain of the coronavirus, called SARS-CoV-2, which struck humanity by an unprecedented disaster a few months later. In response to this pandemic, a publicly available dataset was released on Kaggle which contained information of over 63,000 papers. In order to facilitate the analysis of this large mass of literature, we have created a knowledge graph based on this dataset. Within this knowledge graph, all information of the original dataset is linked together, which makes it easier to search for relevant information. The knowledge graph is also enriched with additional links to appropriate, already existing external resources. In this paper, we elaborate on the different steps performed to construct such a knowledge graph from structured documents. Moreover, we discuss, on a conceptual level, several possible applications and analyses that can be built on top of this knowledge graph. As such, we aim to provide a resource that allows people to more easily build applications that give more insights into the COVID-19 pandemic

eXplainable AI for trustworthy healthcare applications

Acknowledging that AI will inevitably become a central element of clinical practice, this thesis investigates the role of eXplainable AI (XAI) techniques in developing trustworthy AI applications in healthcare. The first part of this thesis focuses on the societal, ethical, and legal aspects of the use of AI in healthcare. It first compares the different approaches to AI ethics worldwide and then focuses on the practical implications of the European ethical and legal guidelines for AI applications in healthcare. The second part of the thesis explores how XAI techniques can help meet three key requirements identified in the initial analysis: transparency, auditability, and human oversight. The technical transparency requirement is tackled by enabling explanatory techniques to deal with common healthcare data characteristics and tailor them to the medical field. In this regard, this thesis presents two novel XAI techniques that incrementally reach this goal by first focusing on multi-label predictive algorithms and then tackling sequential data and incorporating domainspecific knowledge in the explanation process. This thesis then analyzes the ability to leverage the developed XAI technique to audit a fictional commercial black-box clinical decision support system (DSS). Finally, the thesis studies AI explanation’s ability to effectively enable human oversight by studying the impact of explanations on the decision-making process of healthcare professionals

Rule Mining and Sequential Pattern Based Predictive Modeling with EMR Data

Electronic medical record (EMR) data is collected on a daily basis at hospitals and other healthcare facilities to track patients’ health situations including conditions, treatments (medications, procedures), diagnostics (labs) and associated healthcare operations. Besides being useful for individual patient care and hospital operations (e.g., billing, triaging), EMRs can also be exploited for secondary data analyses to glean discriminative patterns that hold across patient cohorts for different phenotypes. These patterns in turn can yield high level insights into disease progression with interventional potential. In this dissertation, using a large scale realistic EMR dataset of over one million patients visiting University of Kentucky healthcare facilities, we explore data mining and machine learning methods for association rule (AR) mining and predictive modeling with mood and anxiety disorders as use-cases. Our first work involves analysis of existing quantitative measures of rule interestingness to assess how they align with a practicing psychiatrist’s sense of novelty/surprise corresponding to ARs identified from EMRs. Our second effort involves mining causal ARs with depression and anxiety disorders as target conditions through matching methods accounting for computationally identified confounding attributes. Our final effort involves efficient implementation (via GPUs) and application of contrast pattern mining to predictive modeling for mental conditions using various representational methods and recurrent neural networks. Overall, we demonstrate the effectiveness of rule mining methods in secondary analyses of EMR data for identifying causal associations and building predictive models for diseases

Foundations and Recent Trends in Multimodal Machine Learning: Principles, Challenges, and Open Questions

Multimodal machine learning is a vibrant multi-disciplinary research field that aims to design computer agents with intelligent capabilities such as understanding, reasoning, and learning through integrating multiple communicative modalities, including linguistic, acoustic, visual, tactile, and physiological messages. With the recent interest in video understanding, embodied autonomous agents, text-to-image generation, and multisensor fusion in application domains such as healthcare and robotics, multimodal machine learning has brought unique computational and theoretical challenges to the machine learning community given the heterogeneity of data sources and the interconnections often found between modalities. However, the breadth of progress in multimodal research has made it difficult to identify the common themes and open questions in the field. By synthesizing a broad range of application domains and theoretical frameworks from both historical and recent perspectives, this paper is designed to provide an overview of the computational and theoretical foundations of multimodal machine learning. We start by defining two key principles of modality heterogeneity and interconnections that have driven subsequent innovations, and propose a taxonomy of 6 core technical challenges: representation, alignment, reasoning, generation, transference, and quantification covering historical and recent trends. Recent technical achievements will be presented through the lens of this taxonomy, allowing researchers to understand the similarities and differences across new approaches. We end by motivating several open problems for future research as identified by our taxonomy