Doctor of Philosophy

dissertationPlatelet aggregation, an important part of the development of blood clots, is a complex process involving both mechanical interaction between platelets and blood, and chemical transport on and o the surfaces of those platelets. Radial Basis Function (RBF) interpolation is a meshfree method for the interpolation of multidimensional scattered data, and therefore well-suited for the development of meshfree numerical methods. This dissertation explores the use of RBF interpolation for the simulation of both the chemistry and mechanics of platelet aggregation. We rst develop a parametric RBF representation for closed platelet surfaces represented by scattered nodes in both two and three dimensions. We compare this new RBF model to Fourier models in terms of computational cost and errors in shape representation. We then augment the Immersed Boundary (IB) method, a method for uid-structure interaction, with our RBF geometric model. We apply the resultant method to a simulation of platelet aggregation, and present comparisons against the traditional IB method. We next consider a two-dimensional problem where platelets are suspended in a stationary fluid, with chemical diusion in the fluid and chemical reaction-diusion on platelet surfaces. To tackle the latter, we propose a new method based on RBF-generated nite dierences (RBF-FD) for solving partial dierential equations (PDEs) on surfaces embedded in 2D domains. To robustly tackle the former, we remove a limitation of the Augmented Forcing method (AFM), a method for solving PDEs on domains containing curved objects, using RBF-based symmetric Hermite interpolation. Next, we extend our RBF-FD method to the numerical solution of PDEs on surfaces embedded in 3D domains, proposing a new method of stabilizing RBF-FD discretizations on surfaces. We perform convergence studies and present applications motivated by biology. We conclude with a summary of the thesis research and present an overview of future research directions, including spectrally-accurate projection methods, an extension of the Regularized Stokeslet method, RBF-FD for variable-coecient diusion, and boundary conditions for RBF-FD

Scattered Data Interpolation on Embedded Submanifolds with Restricted Positive Definite Kernels: Sobolev Error Estimates

In this paper we investigate the approximation properties of kernel interpolants on manifolds. The kernels we consider will be obtained by the restriction of positive definite kernels on $\R^d$, such as radial basis functions (RBFs), to a smooth, compact embedded submanifold \M\subset \R^d. For restricted kernels having finite smoothness, we provide a complete characterization of the native space on \M. After this and some preliminary setup, we present Sobolev-type error estimates for the interpolation problem. Numerical results verifying the theory are also presented for a one-dimensional curve embedded in $\R^3$ and a two-dimensional torus

Scattered data fitting on surfaces using projected Powell-Sabin splines

We present C1 methods for either interpolating data or for fitting scattered data associated with a smooth function on a two-dimensional smooth manifold Ω embedded into R3. The methods are based on a local bivariate Powell-Sabin interpolation scheme, and make use of local projections on the tangent planes. The data fitting method is a two-stage method. We illustrate the performance of the algorithms with some numerical examples, which, in particular, confirm the O(h3) order of convergence as the data becomes dens

A High-Order Kernel Method for Diffusion and Reaction-Diffusion Equations on Surfaces

In this paper we present a high-order kernel method for numerically solving diffusion and reaction-diffusion partial differential equations (PDEs) on smooth, closed surfaces embedded in $\mathbb{R}^d$. For two-dimensional surfaces embedded in $\mathbb{R}^3$, these types of problems have received growing interest in biology, chemistry, and computer graphics to model such things as diffusion of chemicals on biological cells or membranes, pattern formations in biology, nonlinear chemical oscillators in excitable media, and texture mappings. Our kernel method is based on radial basis functions (RBFs) and uses a semi-discrete approach (or the method-of-lines) in which the surface derivative operators that appear in the PDEs are approximated using collocation. The method only requires nodes at "scattered" locations on the surface and the corresponding normal vectors to the surface. Additionally, it does not rely on any surface-based metrics and avoids any intrinsic coordinate systems, and thus does not suffer from any coordinate distortions or singularities. We provide error estimates for the kernel-based approximate surface derivative operators and numerically study the accuracy and stability of the method. Applications to different non-linear systems of PDEs that arise in biology and chemistry are also presented