2,753 research outputs found

    Researching animal research: What the humanities and social sciences can contribute to laboratory animal science and welfare

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    Every year around 80 million scientific procedures are carried out on animals globally. These experiments have the potential to generate new understandings of biology and clinical treatments. They also give rise to ongoing societal debate.This book demonstrates how the humanities and social sciences can contribute to understanding what is created through animal procedures - including constitutional forms of research governance, different institutional cultures of care, the professional careers of scientists and veterinarians, collaborations with patients and publics, and research animals, specially bred for experiments or surplus to requirements.Developing the idea of the animal research nexus, this book explores how connections and disconnections are made between these different elements, how these have reshaped each other historically, and how they configure the current practice and policy of UK animal research

    THE IMPACT OF HUMAN-CENTRIC LIGHTING PARAMETERS ON OLDER ADULT’S PERCEPTION, AND COGNITIVE PERFORMANCE

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    Population aging is a prominent demographic challenge. Older adults face increased risks of sleep dysfunctions, depression, and cognitive impairments due to physical, biological, and psychological factors associated with aging. These behavioral issues elevate safety risks at home, which necessitates the transition to assisted living facilities. Extensive research highlights the influence of healthcare environmental design, particularly related to architectural lighting impacts on residents' well-being and quality of life. To optimize older adults' health and well-being, it is essential to consider both the visual and non-visual effects of architectural lighting. Visual impacts include parameters related to task performance and visual acuity, while non-visual impacts may include outcomes such as circadian rhythm regulation, sleep quality, mood enhancement, and cognitive performance, thereby emphasizing the importance of implementing a holistic conceptual approach to human-centric lighting in indoor environments.While existing gerontology studies have primarily focused on light-level attributes, such as radiant flux, illuminance, and equivalent melanopic lux, there has been limited exploration of spectral and spatial pattern parameters in indoor lighting. The primary objective of this research is to investigate the impact of both quantitative and qualitative aspects of lighting design, including spatial layout characteristics such as uniformity, direction, centrality, and spectral attributes like correlated color temperature (CCT), on the visual perception, preference, mood, cognitive performance, and overall well-being of older adults in assisted living facilities. The study employed a multi-method approach across three main research phases. In phase I, a Q-sort survey involving 60 participants assessed the impact of diverse spatial light patterns on visual perception and preference. In phase II, a within-subject design evaluated the cognitive performance of 32 older adults in similar lighting scenarios within real and virtual environments. Lastly, in phase III, the study examined the relationship between spatial and spectral light patterns and cognitive performance through virtual reality testing with 32 participants. Results revealed significant effects of different spatial light patterns on older adults' environmental impressions, including visual preference, stress levels, and cognitive performance. Uniform and indirect lighting were preferred, with no substantial differences between peripheral and central spatial arrangements of light layers. Non-uniform lighting induced a relaxed impression, while uniform lighting heightened perceived stress. Furthermore, the study demonstrated the suitability of virtual reality environments (VR) for assessing cognitive performance and subjective perception. The findings underscore the substantial influence of spatial and spectral light patterns on the cognitive performance of older adults in assisted living facilities. This research contributes to the understanding of the visual and non-visual effects of human-centric lighting on the well-being of older adults. By considering spatial and spectral light attributes, designers can enhance cognitive function, reduce impairments, and cultivate healthier and more efficient living environments

    Southern Adventist University Undergraduate Catalog 2023-2024

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    Southern Adventist University\u27s undergraduate catalog for the academic year 2023-2024.https://knowledge.e.southern.edu/undergrad_catalog/1123/thumbnail.jp

    Digital Technologies for Teaching English as a Foreign/Second Language: a collective monograph

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    Колективна монографія розкриває різні аспекти використання цифрових технологій у навчанні англійської мови як іноземної/другої мови (цифровий сторітелінг, мобільні застосунки, інтерактивне навчання і онлайн-ігри, тощо) та надає освітянам і дослідникам ресурс для збагачення їхньої професійної діяльності. Окрема увага приділена цифровим інструментам для впровадження соціально-емоційного навчання та інклюзивної освіти на уроках англійської мови. Для вчителів англійської мови, методистів, викладачів вищих закладів освіти, науковців, здобувачів вищої освіти

    Digitalization and Development

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    This book examines the diffusion of digitalization and Industry 4.0 technologies in Malaysia by focusing on the ecosystem critical for its expansion. The chapters examine the digital proliferation in major sectors of agriculture, manufacturing, e-commerce and services, as well as the intermediary organizations essential for the orderly performance of socioeconomic agents. The book incisively reviews policy instruments critical for the effective and orderly development of the embedding organizations, and the regulatory framework needed to quicken the appropriation of socioeconomic synergies from digitalization and Industry 4.0 technologies. It highlights the importance of collaboration between government, academic and industry partners, as well as makes key recommendations on how to encourage adoption of IR4.0 technologies in the short- and long-term. This book bridges the concepts and applications of digitalization and Industry 4.0 and will be a must-read for policy makers seeking to quicken the adoption of its technologies

    2023-2024 Catalog

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    The 2023-2024 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:Degree RequirementsCourse OfferingsUndergraduate and Graduate Rules and Regulation

    Comparative genomics of recent adaptation in Candida pathogens

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    [eng] Fungal infections pose a serious health threat, affecting >1,000 million people and causing ~1.5 million deaths each year. The problem is growing due to insufficient diagnostic and therapeutic options, increased number of susceptible patients, expansion of pathogens partly linked to climate change and the rise of antifungal drug resistance. Among other fungal pathogens, Candida species are a major cause of severe hospital-acquired infections, with high mortality in immunocompromised patients. Various Candida pathogens constitute a public health issue, which require further efforts to develop new drugs, optimize currently available treatments and improve diagnostics. Given the high dynamism of Candida genomes, a promising strategy to improve current therapies and diagnostics is to understand the evolutionary mechanisms of adaptation to antifungal drugs and to the human host. Previous work using in vitro evolution, population genomics, selection inferences and Genome Wide Association Studies (GWAS) have partially clarified such recent adaptation, but various open questions remain. In the three research articles that conform this PhD thesis we addressed some of these gaps from the perspective of comparative genomics. First, we addressed methodological issues regarding the analysis of Candida genomes. Studying recent adaptation in these pathogens requires adequate bioinformatic tools for variant calling, filtering and functional annotation. Among other reasons, current methods are suboptimal due to limited accuracy to identify structural variants from short read sequencing data. In addition, there is a need for easy-to-use, reproducible variant calling pipelines. To address these gaps we developed the “personalized Structural Variation detection” pipeline (perSVade), a framework to call, filter and annotate several variant types, including structural variants, directly from reads. PerSVade enables accurate identification of structural variants in any species of interest, such as Candida pathogens. In addition, our tool automatically predicts the structural variant calling accuracy on simulated genomes, which informs about the reliability of the calling process. Furthermore, perSVade can be used to analyze single nucleotide polymorphisms and copy number-variants, so that it facilitates multi-variant, reproducible genomic studies. This tool will likely boost variant analyses in Candida pathogens and beyond. Second, we addressed open questions about recent adaptation in Candida, using perSVade for variant identification. On the one hand, we investigated the evolutionary mechanisms of drug resistance in Candida glabrata. For this, we used a large-scale in vitro evolution experiment to study adaptation to two commonly-used antifungals: fluconazole and anidulafungin. Our results show rapid adaptation to one or both drugs, with moderate fitness costs and through few mutations in a narrow set of genes. In addition, we characterize a novel role of ERG3 mutations in cross-resistance towards fluconazole in anidulafungin-adapted strains. These findings illuminate the mutational paths leading to drug resistance and cross-resistance in Candida pathogens. On the other hand, we reanalyzed ~2,000 public genomes and phenotypes to understand the signs of recent selection and drug resistance in six major Candida species: C. auris, C. glabrata, C. albicans, C. tropicalis, C. parapsilosis and C. orthopsilosis. We found hundreds of genes under recent selection, suggesting that clinical adaptation is diverse and complex. These involve species-specific but also convergently affected processes, such as cell adhesion, which could underlie conserved adaptive mechanisms. In addition, using GWAS we predicted known drivers of antifungal resistance alongside potentially novel players. Furthermore, our analyses reveal an important role of generally-overlooked structural variants, and suggest an unexpected involvement of (para)sexual recombination in the spread of resistance. Taken together, our findings provide novel insights on how Candida pathogens adapt to human-related environments and suggest candidate genes that deserve future attention. In summary, the results of this thesis improve our knowledge about the mechanisms of recent adaptation in Candida pathogens, which may enable improved therapeutic and diagnostic applications.[cat] Les infeccions fúngiques representen una greu amenaça per a la salut, afectant a més de 1.000 milions de persones i causant aproximadament 1,5 milions de morts cada any. El problema està augmentant a causa d’unes opcions terapèutiques i diagnòstiques insuficients, l'increment del nombre de pacients susceptibles, l'expansió dels patògens parcialment vinculada al canvi climàtic i l'augment de la resistència als fàrmacs antifúngics. D’entre diversos fongs patògens, els llevats del gènere Candida són una causa important d'infeccions nosocomials, amb una alta mortalitat en pacients immunodeprimits. Diverses espècies de Candida constitueixen un problema de salut pública, cosa que requereix més esforços per a desenvolupar nous medicaments, optimitzar els tractaments disponibles i millorar els diagnòstics. Tenint en compte el dinamisme genòmic d’aquests patògens, una estratègia prometedora per millorar les teràpies i diagnòstics actuals és comprendre els mecanismes evolutius d'adaptació als fàrmacs antifúngics i a l’hoste humà. Treballs anteriors utilitzant l'evolució in vitro, la genòmica de poblacions, les inferències de selecció i els estudis d'associació de genoma complet (GWAS, per les sigles en anglès) han aclarit parcialment aquesta adaptació recent, però encara hi ha diverses preguntes obertes. En els tres articles que conformen aquesta tesi doctoral, hem abordat algunes d'aquestes preguntes des de la perspectiva de la genòmica comparativa. En primer lloc, hem abordat qüestions metodològiques relatives a l'anàlisi dels genomes de les espècies Candida. L'estudi de l'adaptació recent en aquests patògens requereix eines bioinformàtiques adequades per a la detecció, filtratge i anotació funcional de variants genètiques. Entre altres raons, els mètodes actuals són subòptims a causa de la limitada precisió per identificar variants estructurals a partir de dades de seqüenciació amb lectures curtes. A més, hi ha una necessitat d’eines computacionals per a la detecció de variants que siguin senzilles d'utilitzar i reproduibles. Per abordar aquestes mancances, hem desenvolupat el mètode bioinformàtic "personalized Structural Variation detection" (perSVade), una eina que permet la detecció, filtratge i anotació de diversos tipus de variants, incloent-hi les variants estructurals, directament des de les lectures. PerSVade permet la identificació precisa de les variants estructurals en qualsevol espècie d'interès, com ara els patògens Candida. A més, la nostra eina prediu automàticament la precisió de la detecció d’aquestes variants en genomes simulats, la qual cosa informa sobre la fiabilitat del procés. Finalment, perSVade es pot utilitzar per analitzar altres tipus de variants, com els polimorfismes de nucleòtid únic o els canvis en el nombre de còpies, facilitant així estudis genòmics integrals i reproduibles. Aquesta eina probablement impulsarà les anàlisis genòmiques en els patògens Candida i també en altres espècies. En segon lloc, hem abordat algunes de les preguntes obertes sobre l'adaptació recent en els llevats Candida, utilitzant perSVade per a la identificació de variants. D'una banda, hem investigat els mecanismes evolutius de resistència als fàrmacs antifúngics en Candida glabrata. Per a això, hem utilitzat un experiment d'evolució in vitro a gran escala per estudiar l'adaptació a dos antifúngics comuns: el fluconazol i l’anidulafungina. Els nostres resultats mostren una adaptació ràpida a un o ambdós fàrmacs, amb un cost per al creixement moderat i a través de poques mutacions en un nombre reduït de gens. A més, hem caracteritzat un paper nou de les mutacions en ERG3 en la resistència creuada al fluconazol en soques adaptades a anidulafungina. Aquests descobriments aclareixen els processos mutacionals que condueixen a la resistència als fàrmacs i a la resistència creuada en els patògens Candida. D'altra banda, hem re-analitzat aproximadament 2.000 genomes i fenotips disponibles en repositoris públics per a comprendre els senyals genòmics de selecció recent i de resistència a fàrmacs antifúngics, en sis espècies rellevants de Candida: C. auris, C. glabrata, C. albicans, C. tropicalis, C. parapsilosis i C. orthopsilosis. Hem trobat centenars de gens sota selecció recent, suggerint que l'adaptació clínica és diversa i complexa. Aquests gens estan relacionats amb funcions específiques de cada espècie, però també trobem processos alterats de manera similar en diferents patògens, com per exemple l’adhesió cel·lular, cosa que indica fenòmens d’adaptació conservats. A part, utilitzant GWAS hem predit mecanismes esperats de resistència a antifúngics i també possibles nous factors. A més, les nostres anàlisis revelen un paper important de les variants estructurals, generalment poc estudiades, i suggereixen una implicació inesperada de la recombinació (para)sexual en la propagació de la resistència. En conjunt, els nostres descobriments proporcionen noves perspectives sobre com els patògens Candida s'adapten als entorns humans, i suggereixen gens candidats que mereixen investigacions futures. En resum, els resultats d’aquesta tesi milloren el nostre coneixement sobre els mecanismes d'adaptació recent en els patògens Candida, cosa que pot permetre el disseny de noves teràpies i diagnòstics

    The development of cognitive workload management framework based on neuronal dynamics principle to maintain train driver’s health and railway safety

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    Fatigue increases the tendency of poor train driving strategy decision. Decision making in cognitive overload and cognitive underload situation mostly outputs bad decisions. Accordingly, train driver’s cognitive function is required to be sTable during travel so that they can give correct response at a given situation. This study constructs a conceptual framework for cognitive workload management (CWM) of train driver by taking the energy expenses from cognition into the account. This study combines objective and subjective cognitive workload analysis to evaluate train driver duty readiness. The objective load analysis was performed through energy level approximation based on neuronal dynamics simulation from 76 brain regions. The cognitive energy expenditure (CEE) calculated from neuron action potential (NAP) and the ion-membrane current (IMC) from the simulation results. The cognitive load (CL) approximated by converts the continuous time-based CEE to discrete frequency-based CL using Fourier series. The subjective cognitive workload obtained from train simulation results followed by 27 participants. The participants fill the questionnaire based on their simulated journey experience. The results of the evaluation used to build readiness evaluation classifier based on control chart. The control chart evaluation helps the management to determine weekly rest period and daily short rest period treatment base on each train driver workload. The CWM framework allows different recovery treatment to be applied to each train driver. The impact of the CWM application is the performance of train drivers are kept stable. Thus, the CWM framework based on CEE is useful to prevent physical and mental fatigu

    A Taxonomy of Freehand Grasping Patterns in Virtual Reality

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    Grasping is the most natural and primary interaction paradigm people perform every day, which allows us to pick up and manipulate objects around us such as drinking a cup of coffee or writing with a pen. Grasping has been highly explored in real environments, to understand and structure the way people grasp and interact with objects by presenting categories, models and theories for grasping approach. Due to the complexity of the human hand, classifying grasping knowledge to provide meaningful insights is a challenging task, which led to researchers developing grasp taxonomies to provide guidelines for emerging grasping work (such as in anthropology, robotics and hand surgery) in a systematic way. While this body of work exists for real grasping, the nuances of grasping transfer in virtual environments is unexplored. The emerging development of robust hand tracking sensors for virtual devices now allow the development of grasp models that enable VR to simulate real grasping interactions. However, present work has not yet explored the differences and nuances that are present in virtual grasping compared to real object grasping, which means that virtual systems that create grasping models based on real grasping knowledge, might make assumptions which are yet to be proven true or untrue around the way users intuitively grasp and interact with virtual objects. To address this, this thesis presents the first user elicitation studies to explore grasping patterns directly in VR. The first study presents main similarities and differences between real and virtual object grasping, the second study furthers this by exploring how virtual object shape influences grasping patterns, the third study focuses on visual thermal cues and how this influences grasp metrics, and the fourth study focuses on understanding other object characteristics such as stability and complexity and how they influence grasps in VR. To provide structured insights on grasping interactions in VR, the results are synthesized in the first VR Taxonomy of Grasp Types, developed following current methods for developing grasping and HCI taxonomies and re-iterated to present an updated and more complete taxonomy. Results show that users appear to mimic real grasping behaviour in VR, however they also illustrate that users present issues around object size estimation and generally a lower variability in grasp types is used. The taxonomy shows that only five grasps account for the majority of grasp data in VR, which can be used for computer systems aiming to achieve natural and intuitive interactions at lower computational cost. Further, findings show that virtual object characteristics such as shape, stability and complexity as well as visual cues for temperature influence grasp metrics such as aperture, category, type, location and dimension. These changes in grasping patterns together with virtual object categorisation methods can be used to inform design decisions when developing intuitive interactions and virtual objects and environments and therefore taking a step forward in achieving natural grasping interaction in VR

    Southern Adventist University Undergraduate Catalog 2022-2023

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    Southern Adventist University\u27s undergraduate catalog for the academic year 2022-2023.https://knowledge.e.southern.edu/undergrad_catalog/1121/thumbnail.jp
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