Semi-Supervised Sparse Coding

Sparse coding approximates the data sample as a sparse linear combination of some basic codewords and uses the sparse codes as new presentations. In this paper, we investigate learning discriminative sparse codes by sparse coding in a semi-supervised manner, where only a few training samples are labeled. By using the manifold structure spanned by the data set of both labeled and unlabeled samples and the constraints provided by the labels of the labeled samples, we learn the variable class labels for all the samples. Furthermore, to improve the discriminative ability of the learned sparse codes, we assume that the class labels could be predicted from the sparse codes directly using a linear classifier. By solving the codebook, sparse codes, class labels and classifier parameters simultaneously in a unified objective function, we develop a semi-supervised sparse coding algorithm. Experiments on two real-world pattern recognition problems demonstrate the advantage of the proposed methods over supervised sparse coding methods on partially labeled data sets

Pan-cancer classifications of tumor histological images using deep learning

Histopathological images are essential for the diagnosis of cancer type and selection of optimal treatment. However, the current clinical process of manual inspection of images is time consuming and prone to intra- and inter-observer variability. Here we show that key aspects of cancer image analysis can be performed by deep convolutional neural networks (CNNs) across a wide spectrum of cancer types. In particular, we implement CNN architectures based on Google Inception v3 transfer learning to analyze 27815 H&E slides from 23 cohorts in The Cancer Genome Atlas in studies of tumor/normal status, cancer subtype, and mutation status. For 19 solid cancer types we are able to classify tumor/normal status of whole slide images with extremely high AUCs (0.995±0.008). We are also able to classify cancer subtypes within 10 tissue types with AUC values well above random expectations (micro-average 0.87±0.1). We then perform a cross-classification analysis of tumor/normal status across tumor types. We find that classifiers trained on one type are often effective in distinguishing tumor from normal in other cancer types, with the relationships among classifiers matching known cancer tissue relationships. For the more challenging problem of mutational status, we are able to classify TP53 mutations in three cancer types with AUCs from 0.65-0.80 using a fully-trained CNN, and with similar cross-classification accuracy across tissues. These studies demonstrate the power of CNNs for not only classifying histopathological images in diverse cancer types, but also for revealing shared biology between tumors. We have made software available at: https://github.com/javadnoorb/HistCNNFirst author draf

Novel Application of Neutrosophic Logic in Classifiers Evaluated under Region-Based Image Categorization System

Neutrosophic logic is a relatively new logic that is a generalization of fuzzy logic. In this dissertation, for the first time, neutrosophic logic is applied to the field of classifiers where a support vector machine (SVM) is adopted as the example to validate the feasibility and effectiveness of neutrosophic logic. The proposed neutrosophic set is integrated into a reformulated SVM, and the performance of the achieved classifier N-SVM is evaluated under an image categorization system. Image categorization is an important yet challenging research topic in computer vision. In this dissertation, images are first segmented by a hierarchical two-stage self organizing map (HSOM), using color and texture features. A novel approach is proposed to select the training samples of HSOM based on homogeneity properties. A diverse density support vector machine (DD-SVM) framework that extends the multiple-instance learning (MIL) technique is then applied to the image categorization problem by viewing an image as a bag of instances corresponding to the regions obtained from the image segmentation. Using the instance prototype, every bag is mapped to a point in the new bag space, and the categorization is transformed to a classification problem. Then, the proposed N-SVM based on the neutrosophic set is used as the classifier in the new bag space. N-SVM treats samples differently according to the weighting function, and it helps reduce the effects of outliers. Experimental results on a COREL dataset of 1000 general purpose images and a Caltech 101 dataset of 9000 images demonstrate the validity and effectiveness of the proposed method

Structural learning for large scale image classification

To leverage large-scale collaboratively-tagged (loosely-tagged) images for training a large number of classifiers to support large-scale image classification, we need to develop new frameworks to deal with the following issues: (1) spam tags, i.e., tags are not relevant to the semantic of the images; (2) loose object tags, i.e., multiple object tags are loosely given at the image level without their locations in the images; (3) missing object tags, i.e. some object tags are missed due to incomplete tagging; (4) inter-related object classes, i.e., some object classes are visually correlated and their classifiers need to be trained jointly instead of independently; (5) large scale object classes, which requires to limit the computational time complexity for classifier training algorithms as well as the storage spaces for intermediate results. To deal with these issues, we propose a structural learning framework which consists of the following key components: (1) cluster-based junk image filtering to address the issue of spam tags; (2) automatic tag-instance alignment to address the issue of loose object tags; (3) automatic missing object tag prediction; (4) object correlation network for inter-class visual correlation characterization to address the issue of missing tags; (5) large-scale structural learning with object correlation network for enhancing the discrimination power of object classifiers. To obtain enough numbers of labeled training images, our proposed framework leverages the abundant web images and their social tags. To make those web images usable, tag cleansing has to be done to neutralize the noise from user tagging preferences, in particularly junk tags, loose tags and missing tags. Then a discriminative learning algorithm is developed to train a large number of inter-related classifiers for achieving large-scale image classification, e.g., learning a large number of classifiers for categorizing large-scale images into a large number of inter-related object classes and image concepts. A visual concept network is first constructed for organizing enumorus object classes and image concepts according to their inter-concept visual correlations. The visual concept network is further used to: (a) identify inter-related learning tasks for classifier training; (b) determine groups of visually-similar object classes and image concepts; and (c) estimate the learning complexity for classifier training. A large-scale discriminative learning algorithm is developed for supporting multi-class classifier training and achieving accurate inter-group discrimination and effective intra-group separation. Our discriminative learning algorithm can significantly enhance the discrimination power of the classifiers and dramatically reduce the computational cost for large-scale classifier training

Zero-Shot Object Detection by Hybrid Region Embedding

Object detection is considered as one of the most challenging problems in computer vision, since it requires correct prediction of both classes and locations of objects in images. In this study, we define a more difficult scenario, namely zero-shot object detection (ZSD) where no visual training data is available for some of the target object classes. We present a novel approach to tackle this ZSD problem, where a convex combination of embeddings are used in conjunction with a detection framework. For evaluation of ZSD methods, we propose a simple dataset constructed from Fashion-MNIST images and also a custom zero-shot split for the Pascal VOC detection challenge. The experimental results suggest that our method yields promising results for ZSD