Computing infrastructure issues in distributed communications systems : a survey of operating system transport system architectures

The performance of distributed applications (such as file transfer, remote login, tele-conferencing, full-motion video, and scientific visualization) is influenced by several factors that interact in complex ways. In particular, application performance is significantly affected both by communication infrastructure factors and computing infrastructure factors. Several communication infrastructure factors include channel speed, bit-error rate, and congestion at intermediate switching nodes. Computing infrastructure factors include (among other things) both protocol processing activities (such as connection management, flow control, error detection, and retransmission) and general operating system factors (such as memory latency, CPU speed, interrupt and context switching overhead, process architecture, and message buffering). Due to a several orders of magnitude increase in network channel speed and an increase in application diversity, performance bottlenecks are shifting from the network factors to the transport system factors.This paper defines an abstraction called an "Operating System Transport System Architecture" (OSTSA) that is used to classify the major components and services in the computing infrastructure. End-to-end network protocols such as TCP, TP4, VMTP, XTP, and Delta-t typically run on general-purpose computers, where they utilize various operating system resources such as processors, virtual memory, and network controllers. The OSTSA provides services that integrate these resources to support distributed applications running on local and wide area networks.A taxonomy is presented to evaluate OSTSAs in terms of their support for protocol processing activities. We use this taxonomy to compare and contrast five general-purpose commercial and experimental operating systems including System V UNIX, BSD UNIX, the x-kernel, Choices, and Xinu

Integration of Internet and Telecommunications- An Architecture for Hybrid Services

In this article, we propose an architecture for hybrid services, i.e., services that span many network technologies, such as the Public Switched Telephone Network (PSTN), cellular networks and networks based on the Internet Protocol (IP). These services will play an important role in the future because they leverage on the existing infrastructures, rather than requiring new and sophisticated mechanisms to be deployed. We explore a few issues related to hybrid services and propose a platform, as well as a set of components, to facilitate their creation and deployment. The existing infrastructure is only required to generate specific events when requests for hybrid services are detected. We present the design of a service layer, based on Java, that handles the treatment of these special requests. Our service layer is provided with a set of generic components realized according to the JavaBeans model. We illustrate the strength of our architecture by discussing two hybrid-service examples: a calendar service and a call forwarding service

Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints

BACKGROUND: Identical DNA methylation differences between maternal and paternal alleles in gametes and adults suggest that the inheritance of genomic imprints is strictly due to the embryonic maintenance of DNA methylation. Such maintenance would occur in association with every cycle of DNA replication, including those of preimplantation embryos. RESULTS: The expression of the somatic form of the Dnmt1 cytosine methyltransferase (Dnmt1s) was examined in cleavage-stage preimplantation mouse embryos. Low concentrations of Dnmt1s are found in 1-, 2-, 4-, and 8-cell embryos, as well as in morulae and blastocysts. Dnmt1s is present in the cytoplasm at all stages, and in the nuclei of all stages except the 1-cell, pronuclear-stage embryo. The related oocyte-derived Dnmt1o protein is also present in nuclei of 8-cell embryos, along with embryo-synthesized Dnmt1s. Dnmt1s protein expressed in 1-cell and 2-cell embryos is derived from the oocyte, whereas the embryo synthesizes its own Dnmt1s from the 2-cell stage onward. CONCLUSION: These observations suggest that Dnmt1s provides maintenance methyltransferase activity for the inheritance of methylation imprints in the early mouse embryo. Moreover, the ability of Dnmt1o and Dnmt1s proteins synthesized at the same time to substitute for one another's maintenance function, but the lack of functional interchange between oocyte- and embryo-synthesized Dnmt1 proteins, suggests that the developmental source is the critical determinant of Dnmt1 function during preimplantation development

An Architecture for the Integration of Internet and Telecommunication Services

In this paper, we propose an architecture for hybrid services, i.e., services that span many network technologies, especially the PSTN and the Internet. These services will play an important role in the future, because they leverage on the existing infrastructures, rather than requiring brand-new and sophisticated mechanisms to be deployed. We explore a few issues related to hybrid services and propose a platform, as well as a set of components, to facilitate their creation and deployment. The existing infrastructure is only required to generate specific events when requests for hybrid services are detected. We present the design of s service layer, based on Java, that handles the treatment of these special requests. Our service layer is provided with a set of generic components realized as Java Beans. Hence, we can provide hybrid services without changing the existing infrastructure. We illustrate this strength of our architecture by discussing the call forwarding service

Active database behaviour: the REFLEX approach

Modern day and new generation applications have more demanding requirements than traditional database management systems (DBMS) are able to support. Two of these requirements, timely responses to the change of database state and application domain knowledge stored within the database, are embodied within active database technology. Currently, there are a number of research prototype active database systems throughout the world. In order for an organisation to use any such prototype system, it may have to forsake existing products and resources and embark on substantial reinvestment in the new database products and associated resources and retraining costs. This approach would clearly be unfavourable as it is expensive both in terms of time and money. A more suitable approach would be to allow active behaviour to be added onto their existing systems. This scenario is addressed within this research. It investigates how best active behaviour can be augmented to existing DBMSs, so as to preserve the investments in an organisation's resources, by examining the following issues, (i.) what form the knowledge model should take, (ii.) should rules and events be modelled as first class objects, (iii.) how will the triggering events be specified, (iv.) how the user will interact with the system. Various design decisions were taken, which were investigated by implementation of a series of working prototypes, on the ONTOS DBMS platform. The resultant REFLEX model was successfully ported and adapted onto a second POET platform. The porting process uncovered some interesting issues regarding preconceived ideas about the portability of open systems

Rift brittle structure, Precambrian ductile structure, and crustal thickness variation within and around the Cenozoic Malawi Rift

This study examines the relationship between the regional brittle structure associated with the Cenozoic southern Malawi Rift and the surrounding ductile structure of the Precambrian crystalline basement, as well as the controls of the Precambrian ductile structure and crustal thickness variation on rift brittle structure.The southern Malawi Rift is characterized by a sharp change in orientation from NNW-trending in the north to NE-trending to the south before terminating against the Paleozoic - Mesozoic Shire Graben. Shuttle Radar Topography Mission (SRTM) Digital Elevation Models (DEM) and RADARSAT are used to map the rift brittle structure whereas aeromagnetic images are used to map Precambrian ductile structure. Variation in crustal thickness are obtained from previously published study that used two-dimensional radially-averaged power spectral analysis of the World Gravity Model 2012 (WGM 2012) to map the Moho depth beneath the southern Malawi Rift and its surroundings. After manually extracting the fault orientations for both the surface and basement structures, the data were divided using geophysical trends in the basement complex to create six structural domains. Each domain was applied over the same geographic area to examine structural inheritance within rift structures using rose diagrams for frequency analysis.Within the study area, the brittle rift structures do not always correspond with the fabric of the basement complex and, in some cases, show only a minor relationship. The surficial structures react to pre-existing weaknesses in three ways: 1) follow the dominate trend of basement anisotropies; 2) cut across all basement anisotropies; or 3) have at least one trend that follows basement anisotropies and one or more trends that do not follow basement structures.Crustal thickness data were also analyzed to examine the influence of crustal thickness heterogeneity on current rift structure. In the study area, crustal thickness seems to be a primary control for rift location and propagation and may correspond to the Niassa Craton underlying parts of the Southern Irumide Belt west of the study area. However, if the pre existing structures are favorably oriented, and severe crustal heterogeneity is absent, the rift will follow established basement structures

Practice-oriented controversies and borrowed epistemic credibility in current evolutionary biology: phylogeography as a case study

Although there is increasing recognition that theory and practice in science are intimately intertwined, philosophy of science perspectives on scientific controversies have been historically focused on theory rather than practice. As a step in the construction of frameworks for understanding controversies linked to scientific practices, here we introduce the notion of borrowed epistemic credibility (BEC), to describe the situation in which scientists, in order to garner support for their own stances, exploit similarities between tenets in their own field and accepted statements or positions properly developed within other areas of expertise. We illustrate the scope of application of our proposal with the analysis of a heavily methods-grounded, recent controversy in phylogeography, a biological subdiscipline concerned with the study of the historical causes of biogeographical variation through population genetics- and phylogenetics-based computer analyses of diversity in DNA sequences, both within species and between closely related taxa. Toward this end, we briefly summarize the arguments proposed by selected authors representing each side of the controversy: the ‘nested clade analysis’ school versus the ‘statistical phylogeography’ orientation. We claim that whereas both phylogeographic ‘research styles’ borrow epistemic credibility from sources such as formal logic, the familiarity of results from other scientific areas, the authority of prominent scientists, or the presumed superiority of quantitative vs. verbal reasoning, ‘theory’ plays essentially no role as a foundation of the controversy. Besides underscoring the importance of strictly methodological and other non-theoretical aspects of controversies in current evolutionary biology, our analysis suggests a perspective with potential usefulness for the re-examination of more general philosophy of biology issues, such as the nature of historical inference, rationality, justification, and objectivity

The genetic basis of disease

Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients