Treatment of dental complications in sickle cell disease.

BACKGROUND: Sickle cell disease is the most common single gene disorder and the commonest haemoglobinopathy found with high prevalence in many populations across the world. Management of dental complications in people with sickle cell disease requires special consideration for three main reasons. Firstly, dental and oral tissues are affected by the blood disorder resulting in several oro-facial abnormalities. Secondly, living with a haemoglobinopathy and coping with its associated serious consequences may result in individuals neglecting their oral health care. Finally, the treatment of these oral complications must be adapted to the systemic condition and special needs of these individuals, in order not to exacerbate or deteriorate their general health.Guidelines for the treatment of dental complications in this population who require special care are unclear and even unavailable in many aspects. Hence this review was undertaken to provide a basis for clinical care by investigating and analysing the existing evidence in the literature for the treatment of dental complications in people with sickle cell disease. OBJECTIVES: To assess methods of treating dental complications in people with sickle cell disease. SEARCH METHODS: We searched the Cochrane Haemoglobinopathies Trials Register, compiled from electronic database searches and handsearching of journals and conference abstract books.Date of last search: 11 April 2016.Additionally, we searched nine online databases (PubMed, Google Scholar, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Literature in the Health Sciences in Latin America and the Caribbean database, African Index Medicus, Index Medicus for South East Asia Region, Index Medicus for the Eastern Mediterranean Region, Indexing of Indian Medical Journals). We also searched the reference lists of relevant articles and reviews and contacted haematologists, experts in fields of dentistry, organizations, pharmaceutical companies and researchers working in this field.Date of last search: 03 March 2016. SELECTION CRITERIA: We searched for published or unpublished randomised controlled studies of treatments for dental complications in people with sickle cell disease. DATA COLLECTION AND ANALYSIS: Two review authors intended to independently extract data and assess the risk of bias of the included studies using standard Cochrane methodologies; however, no studies were identified for inclusion in the review. MAIN RESULTS: No randomised controlled studies were identified. AUTHORS\u27 CONCLUSIONS: This Cochrane review did not identify any randomised controlled studies assessing interventions for the treatment of dental complications in people with sickle cell disease. There is an important need for randomised controlled studies in this area, so as to identify the most effective and safe method for treating dental complications in people with sickle cell disease

Preservation in the age of large-scale digitization

The digitization of millions of books under programs such as Google Book Search and Microsoft Live Search Books is dramatically expanding our ability to search and find information. The aim of these large-scale projects?to make content accessible?is interwoven with the question of how one keeps that content, whether digital or print, fit for use over time. This report by Oya Y. Rieger examines large-scale digital initiatives (LSDIs) to identify issues that will influence the availability and usability, over time, of the digital books these projects create. Ms. Rieger is interim assistant university librarian for digital library and information technologies at the Cornell University Library. The paper describes four large-scale projects?Google Book Search, Microsoft Live Search Books, Open Content Alliance, and the Million Book Project?and their digitization strategies. It then discusses a range of issues affecting the stewardship of the digital collections they create: selection, quality in content creation, technical infrastructure, and organizational infrastructure. The paper also attempts to foresee the likely impacts of large-scale digitization on book collections

BlogForever: D3.1 Preservation Strategy Report

This report describes preservation planning approaches and strategies recommended by the BlogForever project as a core component of a weblog repository design. More specifically, we start by discussing why we would want to preserve weblogs in the first place and what it is exactly that we are trying to preserve. We further present a review of past and present work and highlight why current practices in web archiving do not address the needs of weblog preservation adequately. We make three distinctive contributions in this volume: a) we propose transferable practical workflows for applying a combination of established metadata and repository standards in developing a weblog repository, b) we provide an automated approach to identifying significant properties of weblog content that uses the notion of communities and how this affects previous strategies, c) we propose a sustainability plan that draws upon community knowledge through innovative repository design

Rank Corpuscles : Soil and Identity in Eighteenth-Century Representations

In this dissertation, I analyze scenes of encounter between human beings and human dust in eighteenth-century texts. Ploughmen exhume bones and armor in the arable, consumers taste other people’s excrement in their vegetables, and improvers lime the earth to break down ancient corpses. In process, I find that eighteenth-century British authors recognized the soil as an agent of continuity, with the capacity to preserve, mobilize, and disseminate the material constituents of identity from one body into another. At times, the soil’s powerful co-operative agency is threatening to the integrity of the human self, but I argue that authors negotiate between the threat posed by dirt’s unknowing agency, and the opportunities that such a mediator affords for bridging the aporia wrought by death, partition, and forgetfulness. Exploring agricultural treatises, sermons and natural philosophy as well as georgic poetry, Restoration drama, novels and travelogues, this dissertation engages with new-materialist perspectives on literary history, arguing that eighteenth-century authors saw in soil not just a symbol for regeneration or fragmentation, but a material agent in the production of identity. At the same time, it offers historically focused readings of each text, showing how authors rely on the agency of soil to resolve particular challenges to continuity

Negotiating violence at the feast in medieval British texts

The medieval period has been viewed historically as a time of excessive and senseless violence. This project participates in the ongoing field reassessment of violence in medieval literature as being culturally meaningful, rather than senseless and excessive, by advocating for greater attention to the ways in which medieval writers critiqued violence in their narratives and, by extension, their communities. While scholars readily read the tournaments and battles in medieval texts for such critique, I argue that feast scenes actually provide a clearer view of the ways in which violence is used narratively as a productive interventional force, particularly when latent conflicts that have been obscured by adherence to rigid social systems threaten to destabilize a community. Medieval chivalric and etiquette codes suggest that violence stems from those living outside of their jurisdiction; but the violence in feast halls, ungovernable by those codes, shows that conflict from within the community offers the greatest threat to its stability and must be redressed by meaningful action rather than through a prescribed ritualistic response. Making use of theoretical underpinnings from anthropology and history that characterize the feast as a culturally essential event and medieval violence as a rational and strategically-employed tool of constraint, coercion, and manipulation, I convert the essentially historical question of the cultural importance of feasts into a literary one by close reading feasting scenes and their aftermath in order to consider how the writers in medieval England used the motif of violence at or following the feast to illuminate, critique, and offer correction to social, political, and religious issues tied to the specific concerns of justice, loyalty, and treason within a community. Looking at texts ranging from the Anglo-Saxon epic Beowulf, the Welsh Mabinogion, and Latin Historia Regum Britanniae to chronicle-based works by Geoffrey Chaucer and John Gower, the Middle English Arthurian romances Sir Gawain and the Green Knight and Sir Thomas Malory’s Le Morte Darthur, the Old Norse Clari’s Saga, and outlaw tales of Robin Hood, Gamelyn, and Hereward the Wake, I demonstrate through a comparative approach centered on interpretation and analysis supported with contextual historical evidence that violence associated with the feast is typically presented according to genre expectations and mirrors cultural anxieties that are specific to the community in which and for which a given text was produced. The use of the feast for such a purpose is possible precisely because of its essential quality in a given culture; everyone reading the text knows what the feast is supposed to be, and this common understanding of what a feast is permits the disruptions and violent altercations, rather than the event, to become the narrative focus when they occur. Because medieval society viewed it as a tool to be used, rather than simply a passionate outburst, when violence erupts unexpectedly during or after a feast it is being intentionally performed; since the codes of conduct and etiquette that govern the feast make no accommodation for dealing with that violence, there is no communal sense of how to address it; and so, instances of violence at the feast must be handled in the immediate sense on an individual level. This unscripted response to the violence forces a community in its wake to consider what led to the violence, who was involved, how it was handled, and what to do in its aftermath to try to rectify the issues that led to the violent altercation and determine how to avoid or address further potentially violent conflicts. Ultimately, I argue that while all of the instances of violence at the feast examined in this study are differentiated by genre expectations and culturally specific anxieties, together they reveal a continuous preoccupation on the part of writers in medieval England with the limitations of behavioral standards like the chivalric and conduct codes to control violence effectively. I challenge the idea that simply upholding the standards of conduct set forth by prescriptive manuals is enough to stave off social unrest by demonstrating that in fact, social unrest comes not from misbehavior but from the limitations of codes of behavior to account for interpersonal strife. Since the codes of conduct that prescribe how to behave at events like the feast do not address how to deal with latent conflict, when violence does erupt it can become a productive force for meaningful change, because it reveals interpersonal issues that the codes seek to repress and forces the community to deal with them

Elite Landscapes in Late Medieval and Early Modern East Anglia: Families, Residences and the Development of Exclusivity

Abstract This thesis examines the changing boundaries between the elite and the vernacular landscape during the fifteenth, sixteenth and early seventeenth centuries. The study takes an explicitly individualistic approach, considering the careers, allegiances, relationships and ambitions of the people who created and inhabited elite landscapes. By including historicised biographies within the framework of a regional landscape study it has been possible to look beneath broad cultural and social themes and identify some of the motives and ambitions that may have influenced the development of exclusivity at particular locations. For the purposes of this thesis exclusivity refers to the process of expanding the area of demesne in order to create consciously orchestrated elite landscapes. This thesis will argue that a range of scenarios expressed the exclusivity of the elite landscape and demarcated it from the vernacular. The ability to control and direct movement around and through elite landscapes was an important aspect of exclusivity, access to some areas being denied, whilst being actively encouraged where status-display was the paramount concern. Impressions of rank and superiority were conveyed by the careful management of potential interaction with various social groups, different messages being presented to audiences depending on their perceived position in society. The period under consideration is usually divided between the specialisms of medieval and early modern history and is rarely considered as a unity. However, by dismissing conventional periodisation it has been possible to examine the processes that gradually changed the relationship between residences, elite households and their surroundings. The research presented here traces the rise and decline of families and their houses as they responded to the challenges and opportunities offered during a time of momentous change. Detailed micro-studies have been combined with a synthesis of evidence from a multiplicity of sources and set within the context of the transition from medieval to early-modern society. The adoption of the Landscape Approach has provided a framework within which theoretical concepts could be tested by empirical research. The resulting thesis argues that the expansion of exclusivity promoted the development of landscapes that were designed to legitimise the status and authority of the people who created them and provide them with idealised settings for their residences

Digital Image Users and Reuse: Enhancing practitioner discoverability of digital library reuse based on user file naming behavior

Diese Dissertation untersucht Geräte, die Praktiker verwenden, um die Wiederverwendung von digitalen Bibliotheksmaterialien zu entdecken. Der Autor führt zwei Verifikationsstudien durch, in denen zwei zuvor angewandte Strategien untersucht werden, die Praktiker verwenden, um die Wiederverwendung digitaler Objekte zu identifizieren, insbesondere Google Images Reverse Image Lookup (RIL) und eingebettete Metadaten. Es beschreibt diese Strategiebeschränkungen und bietet einen neuen, einzigartigen Ansatz zur Verfolgung der Wiederverwendung, indem der Suchansatz des Autors basierend auf dem Benennungsverhalten von Benutzerdateien verwendet wird. Bei der Untersuchung des Nutzens und der Einschränkungen von Google Images und eingebetteten Metadaten beobachtet und dokumentiert der Autor ein Muster des Benennungsverhaltens von Benutzerdateien, das vielversprechend ist, die Wiederverwendung durch den Praktiker zu verbessern. Der Autor führt eine Untersuchung zur Bewertung der Dateibenennung durch, um dieses Muster des Verhaltens der Benutzerdateibenennung und die Auswirkungen der Dateibenennung auf die Suchmaschinenoptimierung zu untersuchen. Der Autor leitet mehrere signifikante Ergebnisse ab, während er diese Studie fertigstellt. Der Autor stellt fest, dass Google Bilder aufgrund der Änderung des Algorithmus kein brauchbares Werkzeug mehr ist, um die Wiederverwendung durch die breite Öffentlichkeit oder andere Benutzer zu entdecken, mit Ausnahme von Benutzern aus der Industrie. Eingebettete Metadaten sind aufgrund der nicht persistenten Natur eingebetteter Metadaten kein zuverlässiges Bewertungsinstrument. Der Autor stellt fest, dass viele Benutzer ihre eigenen Dateinamen generieren, die beim Speichern und Teilen von digitalen Bildern fast ausschließlich für Menschen lesbar sind. Der Autor argumentiert, dass, wenn Praktiker Suchbegriffe nach den "aggregierten Dateinamen" modellieren, sie ihre Entdeckung wiederverwendeter digitaler Objekte erhöhen.This dissertation explores devices practitioners utilize to discover the reuse of digital library materials. The author performs two verification studies investigating two previously employed strategies that practitioners use to identify digital object reuse, specifically Google Images reverse image lookup (RIL) and embedded metadata. It describes these strategy limitations and offers a new, unique approach for tracking reuse by employing the author's search approach based on user file naming behavior. While exploring the utility and limitations of Google Images and embedded metadata, the author observes and documents a pattern of user file naming behavior that exhibits promise for improving practitioner's discoverability of reuse. The author conducts a file naming assessment investigation to examine this pattern of user file naming behavior and the impact of file naming on search engine optimization. The author derives several significant findings while completing this study. The author establishes that Google Images is no longer a viable tool to discover reuse by the general public or other users except for industry users because of its algorithm change. Embedded metadata is not a reliable assessment tool because of the non-persistent nature of embedded metadata. The author finds that many users generate their own file names, almost exclusively human-readable when saving and sharing digital images. The author argues that when practitioners model search terms after the "aggregated file names" they increase their discovery of reused digital objects

Digital Methods in the Humanities: Challenges, Ideas, Perspectives

Digital Humanities is a transformational endeavor that not only changes the perception, storage, and interpretation of information but also of research processes and questions. It also prompts new ways of interdisciplinary communication between humanities scholars and computer scientists. This volume offers a unique perspective on digital methods for and in the humanities. It comprises case studies from various fields to illustrate the challenge of matching existing textual research practices and digital tools. Problems and solutions with and for training tools as well as the adjustment of research practices are presented and discussed with an interdisciplinary focus

Digital Methods in the Humanities

Digital Humanities is a transformational endeavor that not only changes the perception, storage, and interpretation of information but also of research processes and questions. It also prompts new ways of interdisciplinary communication between humanities scholars and computer scientists. This volume offers a unique perspective on digital methods for and in the humanities. It comprises case studies from various fields to illustrate the challenge of matching existing textual research practices and digital tools. Problems and solutions with and for training tools as well as the adjustment of research practices are presented and discussed with an interdisciplinary focus

Corpus Linguistics and 17th-Century Prostitution

Corpus linguistics has much to offer history, being as both disciplines engage so heavily in analysis of large amounts of textual material. This book demonstrates the opportunities for exploring corpus linguistics as a method in historiography and the humanities and social sciences more generally. Focusing on the topic of prostitution in 17th-century England, it shows how corpus methods can assist in social research, and can be used to deepen our understanding and comprehension. McEnery and Baker draw principally on two sources – the newsbook Mercurius Fumigosis and the Early English Books Online Corpus. This scholarship on prostitution and the sex trade offers insight into the social position of women in history