Dysfunctions of highly parallel real-time machines as 'developmental disorders': Security concerns and a Caveat Emptor

A cognitive paradigm for gene expression in developmental biology that is based on rigorous application of the asymptotic limit theorems of information theory can be adapted to highly parallel real-time computing. The coming Brave New World of massively parallel 'autonomic' and 'Self-X' machines driven by the explosion of multiple core and molecular computing technologies will not be spared patterns of canonical and idiosyncratic failure analogous to the developmental disorders affecting organisms that have had the relentless benefit of a billion years of evolutionary pruning. This paper provides a warning both to potential users of these machines and, given that many such disorders can be induced by external agents, to those concerned with larger scale matters of homeland security

Spatial pattern formation induced by Gaussian white noise

The ability of Gaussian noise to induce ordered states in dynamical systems is here presented in an overview of the main stochastic mechanisms able to generate spatial patterns. These mechanisms involve: (i) a deterministic local dynamics term, accounting for the local rate of variation of the field variable, (ii) a noise component (additive or multiplicative) accounting for the unavoidable environmental disturbances, and (iii) a linear spatial coupling component, which provides spatial coherence and takes into account diffusion mechanisms. We investigate these dynamics using analytical tools, such as mean-field theory, linear stability analysis and structure function analysis, and use numerical simulations to confirm these analytical results.Comment: 11 pages, 8 figure

Consciousness CLEARS the Mind

A full understanding of consciouness requires that we identify the brain processes from which conscious experiences emerge. What are these processes, and what is their utility in supporting successful adaptive behaviors? Adaptive Resonance Theory (ART) predicted a functional link between processes of Consciousness, Learning, Expectation, Attention, Resonance, and Synchrony (CLEARS), includes the prediction that "all conscious states are resonant states." This connection clarifies how brain dynamics enable a behaving individual to autonomously adapt in real time to a rapidly changing world. The present article reviews theoretical considerations that predicted these functional links, how they work, and some of the rapidly growing body of behavioral and brain data that have provided support for these predictions. The article also summarizes ART models that predict functional roles for identified cells in laminar thalamocortical circuits, including the six layered neocortical circuits and their interactions with specific primary and higher-order specific thalamic nuclei and nonspecific nuclei. These prediction include explanations of how slow perceptual learning can occur more frequently in superficial cortical layers. ART traces these properties to the existence of intracortical feedback loops, and to reset mechanisms whereby thalamocortical mismatches use circuits such as the one from specific thalamic nuclei to nonspecific thalamic nuclei and then to layer 4 of neocortical areas via layers 1-to-5-to-6-to-4.National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624

Conflict and Computation on Wikipedia: a Finite-State Machine Analysis of Editor Interactions

What is the boundary between a vigorous argument and a breakdown of relations? What drives a group of individuals across it? Taking Wikipedia as a test case, we use a hidden Markov model to approximate the computational structure and social grammar of more than a decade of cooperation and conflict among its editors. Across a wide range of pages, we discover a bursty war/peace structure where the systems can become trapped, sometimes for months, in a computational subspace associated with significantly higher levels of conflict-tracking "revert" actions. Distinct patterns of behavior characterize the lower-conflict subspace, including tit-for-tat reversion. While a fraction of the transitions between these subspaces are associated with top-down actions taken by administrators, the effects are weak. Surprisingly, we find no statistical signal that transitions are associated with the appearance of particularly anti-social users, and only weak association with significant news events outside the system. These findings are consistent with transitions being driven by decentralized processes with no clear locus of control. Models of belief revision in the presence of a common resource for information-sharing predict the existence of two distinct phases: a disordered high-conflict phase, and a frozen phase with spontaneously-broken symmetry. The bistability we observe empirically may be a consequence of editor turn-over, which drives the system to a critical point between them.Comment: 23 pages, 3 figures. Matches published version. Code for HMM fitting available at http://bit.ly/sfihmm ; time series and derived finite state machines at bit.ly/wiki_hm

Brain processing of contagious itch in patients with atopic dermatitis

Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined Contagious itch (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that AD-patients could profit from when they are confronted with itch-inducing situations in daily life. Therefore, this study investigated the brain processing of CI in AD-patients. 11 AD-patients underwent fMRI scans during the presentation of an itch inducing experimental video (EV) and a non-itch inducing control video (CV). Perfusion based brain activity was measured using arterial spin labeling functional MRI. As expected, the EV compared to the CV led to an increase in itch and scratching (p \u3c 0.05). CI led to a significant increase in brain activity in the supplementary motor area, left ventral striatum and right orbitofrontal cortex (threshold: p \u3c 0.001; cluster size k \u3e 50). Moreover, itch induced by watching the EV was by trend correlated with activity in memory-related regions including the temporal cortex and the (pre-) cuneus as well as the posterior operculum, a brain region involved in itch processing (threshold: p \u3c 0.005; cluster size k \u3e 50). These findings suggest that the fronto-striatal circuit, which is associated with the desire to scratch, might be a target region for non-invasive treatments in AD patients. © 2017 Schut, Mochizuki, Grossman, Lin, Conklin, Mohamed, Gieler, Kupfer and Yosipovitch