Fast-Decodable Asymmetric Space-Time Codes from Division Algebras

Multiple-input double-output (MIDO) codes are important in the near-future wireless communications, where the portable end-user device is physically small and will typically contain at most two receive antennas. Especially tempting is the 4 x 2 channel due to its immediate applicability in the digital video broadcasting (DVB). Such channels optimally employ rate-two space-time (ST) codes consisting of (4 x 4) matrices. Unfortunately, such codes are in general very complex to decode, hence setting forth a call for constructions with reduced complexity. Recently, some reduced complexity constructions have been proposed, but they have mainly been based on different ad hoc methods and have resulted in isolated examples rather than in a more general class of codes. In this paper, it will be shown that a family of division algebra based MIDO codes will always result in at least 37.5% worst-case complexity reduction, while maintaining full diversity and, for the first time, the non-vanishing determinant (NVD) property. The reduction follows from the fact that, similarly to the Alamouti code, the codes will be subsets of matrix rings of the Hamiltonian quaternions, hence allowing simplified decoding. At the moment, such reductions are among the best known for rate-two MIDO codes. Several explicit constructions are presented and shown to have excellent performance through computer simulations.Comment: 26 pages, 1 figure, submitted to IEEE Trans. Inf. Theory, October 201

Order-Theoretic Methods for Space-Time Coding: Symmetric and Asymmetric Designs

Siirretty Doriast

Optics for AI and AI for Optics

Artificial intelligence is deeply involved in our daily lives via reinforcing the digital transformation of modern economies and infrastructure. It relies on powerful computing clusters, which face bottlenecks of power consumption for both data transmission and intensive computing. Meanwhile, optics (especially optical communications, which underpin today’s telecommunications) is penetrating short-reach connections down to the chip level, thus meeting with AI technology and creating numerous opportunities. This book is about the marriage of optics and AI and how each part can benefit from the other. Optics facilitates on-chip neural networks based on fast optical computing and energy-efficient interconnects and communications. On the other hand, AI enables efficient tools to address the challenges of today’s optical communication networks, which behave in an increasingly complex manner. The book collects contributions from pioneering researchers from both academy and industry to discuss the challenges and solutions in each of the respective fields

AAS/GSFC 13th International Symposium on Space Flight Dynamics

This conference proceedings preprint includes papers and abstracts presented at the 13th International Symposium on Space Flight Dynamics. Cosponsored by American Astronautical Society and the Guidance, Navigation and Control Center of the Goddard Space Flight Center, this symposium featured technical papers on a wide range of issues related to orbit-attitude prediction, determination, and control; attitude sensor calibration; attitude dynamics; and mission design

Explicit Building Block Multiobjective Evolutionary Computation: Methods and Applications

This dissertation presents principles, techniques, and performance of evolutionary computation optimization methods. Concentration is on concepts, design formulation, and prescription for multiobjective problem solving and explicit building block (BB) multiobjective evolutionary algorithms (MOEAs). Current state-of-the-art explicit BB MOEAs are addressed in the innovative design, execution, and testing of a new multiobjective explicit BB MOEA. Evolutionary computation concepts examined are algorithm convergence, population diversity and sizing, genotype and phenotype partitioning, archiving, BB concepts, parallel evolutionary algorithm (EA) models, robustness, visualization of evolutionary process, and performance in terms of effectiveness and efficiency. The main result of this research is the development of a more robust algorithm where MOEA concepts are implicitly employed. Testing shows that the new MOEA can be more effective and efficient than previous state-of-the-art explicit BB MOEAs for selected test suite multiobjective optimization problems (MOPs) and U.S. Air Force applications. Other contributions include the extension of explicit BB definitions to clarify the meanings for good single and multiobjective BBs. A new visualization technique is developed for viewing genotype, phenotype, and the evolutionary process in finding Pareto front vectors while tracking the size of the BBs. The visualization technique is the result of a BB tracing mechanism integrated into the new MOEA that enables one to determine the required BB sizes and assign an approximation epistasis level for solving a particular problem. The culmination of this research is explicit BB state-of-the-art MOEA technology based on the MOEA design, BB classifier type assessment, solution evolution visualization, and insight into MOEA test metric validation and usage as applied to test suite, deception, bioinformatics, unmanned vehicle flight pattern, and digital symbol set design MOPs

Enumeration, conformation sampling and population of libraries of peptide macrocycles for the search of chemotherapeutic cardioprotection agents

Peptides are uniquely endowed with features that allow them to perturb previously difficult to drug biomolecular targets. Peptide macrocycles in particular have seen a flurry of recent interest due to their enhanced bioavailability, tunability and specificity. Although these properties make them attractive hit-candidates in early stage drug discovery, knowing which peptides to pursue is non‐trivial due to the magnitude of the peptide sequence space. Computational screening approaches show promise in their ability to address the size of this search space but suffer from their inability to accurately interrogate the conformational landscape of peptide macrocycles. We developed an in‐silico compound enumerator that was tasked with populating a conformationally laden peptide virtual library. This library was then used in the search for cardio‐protective agents (that may be administered, reducing tissue damage during reperfusion after ischemia (heart attacks)). Our enumerator successfully generated a library of 15.2 billion compounds, requiring the use of compression algorithms, conformational sampling protocols and management of aggregated compute resources in the context of a local cluster. In the absence of experimental biophysical data, we performed biased sampling during alchemical molecular dynamics simulations in order to observe cyclophilin‐D perturbation by cyclosporine A and its mitochondrial targeted analogue. Reliable intermediate state averaging through a WHAM analysis of the biased dynamic pulling simulations confirmed that the cardio‐protective activity of cyclosporine A was due to its mitochondrial targeting. Paralleltempered solution molecular dynamics in combination with efficient clustering isolated the essential dynamics of a cyclic peptide scaffold. The rapid enumeration of skeletons from these essential dynamics gave rise to a conformation laden virtual library of all the 15.2 Billion unique cyclic peptides (given the limits on peptide sequence imposed). Analysis of this library showed the exact extent of physicochemical properties covered, relative to the bare scaffold precursor. Molecular docking of a subset of the virtual library against cyclophilin‐D showed significant improvements in affinity to the target (relative to cyclosporine A). The conformation laden virtual library, accessed by our methodology, provided derivatives that were able to make many interactions per peptide with the cyclophilin‐D target. Machine learning methods showed promise in the training of Support Vector Machines for synthetic feasibility prediction for this library. The synergy between enumeration and conformational sampling greatly improves the performance of this library during virtual screening, even when only a subset is used

High performance systems

This document provides a written compilation of the presentations and viewgraphs from the 1994 Conference on High Speed Computing given at the High Speed Computing Conference, {open_quotes}High Performance Systems,{close_quotes} held at Gleneden Beach, Oregon, on April 18 through 21, 1994