143,905 research outputs found
Metabolite changes in blood predict the onset of tuberculosis
Immunogenetics and cellular immunology of bacterial infectious disease
Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19
This work was supported by the NIHR BioResource, the NIHR Cambridge Biomedical Research Centre and the NIHR Cambridge Clinical Research Facility. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We thank NIHR BioResource volunteers for their participation, and gratefully acknowledge NIHR BioResource centres, NHS Trusts and staff for their contribution. FV plasma assays were performed by the NIHR Cambridge Biochemical Assay Laboratory. The Cambridge University Hospitals Research Tissue Bank is supported by the NIHR Cambridge Biomedical Research Centre. FV constructs were prepared and expressed by Peak Proteins. Neutrophil proteins were characterized at the Mass Spectrometry Facility at the University of Dundee and the QMRI flow cytometry and cell sorting facility. Sequencing was supported by Paul Coupland from the CRUK Cambridge Institute Genomics Core. The graphical abstract was produced using Biorender (https://biorender.com/). The work was funded by awards from NIHR to the NIHR BioResource and the NIHR Cambridge Biomedical Research Centre, Evelyn Trust, Addenbrooke's Charitable Trust, UKRI/NIHR funding through the UK Coronavirus Immunology Consortium (UK-CIC) and a CSO award (COV/DUN/20/01). KGCS holds a Wellcome Trust Investigator award. BG holds an award from the Aging Biology Foundation Europe to BG. RKG holds a Wellcome Senior Fellowship (WT108082AIA). PK is supported by the Australian and New Zealand Society of Nephrology and the Royal Australasian College of Physicians. SRW holds a Wellcome Trust Senior Clinical Fellowship (209220). ERW holds a Wellcome Clinical Training Fellowship award (108717/Z/15/Z). NM was supported by a DFG Research Fellowship. PFC is a Wellcome Trust Principal Research Fellow (212219/Z/18/Z), and a NIHR Senior Investigator, and receives support from the Medical Research Council (MRC) Mitochondrial Biology Unit, the MRC International Centre for Genomic Medicine in Neuromuscular Disease, the Leverhulme Trust, an MRC research grant, and an Alzheimer's Society Project Grant. JAN holds a Wellcome Trust Senior Research Fellowship (215477/Z/19/Z).Peer reviewedPublisher PD
Исследования функциональности и состояния защитных сооружений ГО г. Юрги
Immunogenetics and cellular immunology of bacterial infectious disease
Performance Prediction of Helical-Type Seawater MHD Power Generator for Enlargement
Immunogenetics and cellular immunology of bacterial infectious disease
Necrotizing fasciitis of the neck: case presentation
Necrotizing fasciitis represents a severe and rare infectious disease, which is accompanied by extended necrosis of subcutaneous tissues and fascia layers, having as a result gangrene of the teguments. To reduce mortality associated with this disease, a rapid diagnosis is necessary as well as aggressive surgical treatment, accompanied by adequate, aggressive antibiotic therapy. As a rule, etiology is teeth related, with the condition more common in immunology-depressed patients. This article presents the experience of the authors regarding a case presentation of necrotizing fasciitis with typical clinical expression and management of the disease in an immunological-depressed patient. Further data on diagnosis, microbiology, clinical manifestations, therapy principles, and prognosis are yet needed for atypical cases
Musings on genome medicine: Crohn's disease
The inflammatory bowel diseases, Crohn's disease and ulcerative colitis, pose a fascinating challenge to specialists in gastroenterology, infectious diseases, immunology and genetics and an often crushing burden to patients and their families
The James A. Baker Institute for Animal Health Annual Report 1996
The James A. Baker Institute for Animal Health Annual Report 1996Topics in this Annual Report include: A Message from the Director (Douglas F. Antczak); Staff of the Baker Institute; Perspectives; Advisory Council; Recognitions; Memorials; Infectious Diseases and Immunology (Hadley C. Stephenson Laboratory for the Study of Canine Diseases, Albert C. Bostwick Laboratory of Molecular Biology, Immunology Laboratory, Mucosal Immunity Laboratory, Equine Genetics Center); A Retrospective [Leland Carmichael] (Giralda Laboratory for Canine Infectious Diseases); Genetics and Develepment John M. Olin Laboratory for the Study of Canine Bone and Joint Disease, Laboratory of Cellular Growth and Differentiation, Laboratory for the Study of Inherited Canine Reproductive Diseases, Donnelley Laboratory of Gene Regulation and Expression, Inherited Eye Disease Studies Unit); Beyond the Laboratory (Baker Institute Scientific Conference Series, Honorable Mentions, Publications); Acknowledgements
Vaccines
This is a lecture in the PEER Liberia Infectious Disease Lecture Series. This presentation provides an overview of: prevention and control of vaccine preventable diseases; global impact of vaccines - successes and challenges; and vaccine fundamentals - basic immunology, introduction to vaccinology
Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
Immunogenetics and cellular immunology of bacterial infectious disease
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