1,126 research outputs found
The Molecular Genetics of Wilms Tumour And The Wilms Tumour Predisposition Syndromes
A molecular genetic analysis of Wilms tumour and the Wilms tumour predisposition syndromes. Genetic analysis of Wilms tumour (WT) and WT predisposition syndromes has revealed that a complex set of genetic events are associated with the development of this tumour. This thesis analyses specific genetic loci in a series of patients and tumours in order to gain a greater understanding of the molecular aetiology of this tumour. Sporadic Wilms tumours are the most common type and constitute the bulk of the analysis presented. The WT1 gene in 11p13 was analysed using SSCP and DNA sequencing in 36 tumours. Mutations were only found in 1 of 32 sporadic Wilms tumours, strongly suggesting that WT1 has only a limited role to play in the development of sporadic WT. Karyotypic analysis and Loss of Heterozygosity (LOH) studies have implicated loci on chromosome arms 7p and 16q in Wilms tumourigenesis. Paired constitutional and tumour DNA from sporadic WT were studied for LOH using polymorphic microsatellite repeats from both these chromosomes. 15% showed LOH for 16q and there was evidence for a worse outcome in this small group. LOH for 7p was found in 10% of cases and in one tumour a homozygous deletion was detected, this finding suggests the locaton of a tumour suppressor gene on 7p. Previous analysis of Beckwith-Wiedemann syndrome (BWS) patients has suggested another WT predisposition gene lies in 11p15. Two patients with constitutional translocations were analysed using fluoresence in situ hybridisation (FISH) and trisomy for the 11p15 region was identified. Analysis of the extent of the triplication was studied using 11p15-specific cosmids. The importance of these observations in the development of WT are discussed. Perlman syndrome (PS) is another WT predisposition syndrome and cytogenetic analysis in two patients with this syndrome suggested rearrangements of 11p15. Detailed FISH and molecular analysis has been used to characterise the nature of these rearrangments. The data presented in this thesis adds to the body of evidence demonstrating the complex nature of the molecular mechanisms underlying Wilms tumorigenesis
Biometrics
Biometrics uses methods for unique recognition of humans based upon one or more intrinsic physical or behavioral traits. In computer science, particularly, biometrics is used as a form of identity access management and access control. It is also used to identify individuals in groups that are under surveillance. The book consists of 13 chapters, each focusing on a certain aspect of the problem. The book chapters are divided into three sections: physical biometrics, behavioral biometrics and medical biometrics. The key objective of the book is to provide comprehensive reference and text on human authentication and people identity verification from both physiological, behavioural and other points of view. It aims to publish new insights into current innovations in computer systems and technology for biometrics development and its applications. The book was reviewed by the editor Dr. Jucheng Yang, and many of the guest editors, such as Dr. Girija Chetty, Dr. Norman Poh, Dr. Loris Nanni, Dr. Jianjiang Feng, Dr. Dongsun Park, Dr. Sook Yoon and so on, who also made a significant contribution to the book
Aerospace medicine and biology: A continuing bibliography with indexes
This bibliography lists 148 reports, articles and other documents introduced into the NASA scientific and technical information system in December 1984
2014 Abstract Booklet
Complete Schedule of Events for the 16th Annual Undergraduate Research Symposium at Minnesota State University, Mankato
Strategies for mutation detection in sex-chromosome related disorders
Summary available: p.
Aerospace medicine and biology: A continuing bibliography with indexes (supplement 352)
This bibliography lists 147 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during July 1991. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance
XXII International Conference on Mechanics in Medicine and Biology - Abstracts Book
This book contain the abstracts presented the XXII ICMMB, held in Bologna in September 2022. The abstracts are divided following the sessions scheduled during the conference
HyperCell: A Bio-inspired Design Framework for Real-time Interactive Architectures
This pioneering research focuses on Biomimetic Interactive Architecture using âComputationâ, âEmbodimentâ, and âBiologyâ to generate an intimate embodied convergence to propose a novel rule-based design framework for creating organic architectures composed of swarm-based intelligent components. Furthermore, the research boldly claims that Interactive Architecture should emerge as the next truly Organic Architecture. As the world and society are dynamically changing, especially in this digital era, the research dares to challenge the Utilitas, Firmitas, and Venustas of the traditional architectural Weltanschauung, and rejects them by adopting the novel notion that architecture should be dynamic, fluid, and interactive. This project reflects a trajectory from the 1960âs with the advent of the avant-garde architectural design group, Archigram, and its numerous intriguing and pioneering visionary projects. Archigramâs non-standard, mobile, and interactive projects profoundly influenced a new generation of architects to explore the connection between technology and their architectural projects. This research continues this trend of exploring novel design thinking and the framework of Interactive Architecture by discovering the interrelationship amongst three major topics: âComputationâ, âEmbodimentâ, and âBiologyâ. The project aims to elucidate pioneering research combining these three topics in one discourse: âBio-inspired digital architectural designâ. These three major topics will be introduced in this Summary.
âComputationâ, is any type of calculation that includes both arithmetical and nonarithmetical steps and follows a well-defined model understood and described as, for example, an algorithm. But, in this research, refers to the use of data storage, parametric design application, and physical computing for developing informed architectural designs. âFormâ has always been the most critical focus in architectural design, and this focus has also been a major driver behind the application computational design in Architecture. Nonetheless, this research will interpret the term âFormâ in architecture as a continual âinformation processorâ rather than the result of information processing. In other words, âFormâ should not be perceived only as an expressive appearance based computational outcome but rather as a real-time process of information processing, akin to organic âFormationâ. Architecture embodying kinetic ability for adjusting or changing its shape with the ability to process the surroundings and feedback in accordance with its free will with an inherent interactive intelligent movement of a living body. Additionally, it is also crucial to address the question of whether computational technologies are being properly harnessed, if they are only used for form-generating purposes in architecture design, or should this be replaced with real-time information communication and control systems to produce interactive architectures, with embodied computation abilities?
âEmbodimentâ in the context of this research is embedded in Umberto Ecoâs vision on Semiotics, theories underlying media studies in Marshall McLuhanâs âBody Extensionâ (McLuhan, 1964), the contemporary philosophical thought of âBody Without Organsâ (Gilles Deleuze and FĂ©lix Guattari, 1983), the computational Logic of âSwarm Behaviorâ and the philosophical notion of âMonadologyâ proposed by Gottfried Leibniz (Leibniz, 1714). Embodied computation and design are predominant today within the wearable computing and smart living domains, which combine Virtual and Real worlds. Technical progress and prowess in VR development also contribute to advancing 3D smart architectural design and display solutions. The proposed âOrganic body-like architectural spacesâ emphasize upon the realization of a body-like interactive space. Developing Interactive Architecture will imply eliciting the collective intelligence prevalent in nature and the virtual world of Big Data. Interactive Architecture shall thus embody integrated Information exchange protocols and decision-making systems in order to possess organic body-like qualities.
âBiologyâ, in this research explores biomimetic principles intended to create purposedriven kinetic and organic architecture. This involves a detailed study/critique of organic architecture, generating organic shapes, performance optimization based digital fabrication techniques and kinetic systems. A holistic bio-inspired architecture embodies multiple performance criteria akin to natural systems, which integrate structural, infrastructure performances throughout the growth of an organic body. Such a natural morphogenesis process of architectural design explores what Janine M. Benyus described as âlearning the natural processâ. Profoundly influenced by the processes behind morphogenesis, the research further explores Evolutionary Development Biology (Evo-Devo) explaining how embryological regulation strongly affect the resulting formations. Evo-Devo in interactive architecture implies the development of architecture based on three fundamental principles: âSimple to Complexâ, âGeometric Information Distributionâ, and âOn/Off Switch and Trigger.â
The research seeks to create a relatively intelligent architectural body, and the tactile interactive spatial environment by applying the extracted knowledge from the study of the aforementioned principles of Evo-Devo in the following fashion:
A. Extract a Self-Similar Componential System based approach from the âSimple to Complexâ principle of Evo-Devo
B. Extract the idea of âCollective Intelligenceâ from âGeometric information Distributionâ principle of Evo-Devo
C. Extract the principle of âAssembly Regulationâ from âOn/Off switch and triggerâ principle of Evo-Devo
The âHyperCellâ research, through an elaborate investigation on the three aforementioned topics, develops a design framework for developing real-time adaptive spatial systems. HyperCell does this, by developing a system of transformable cubic elements which can self-organize, adapt and interact in real-time. These Hypercells shall comprise an organic space which can adjust itself in relation to our human bodies. The furniture system is literally reified and embodied to develop an intra-active space that proactively provokes human movement. The space thus acquires an emotive dimension and can become your pet, partner, or even friend, and might also involve multiple usabilities of the same space. The research and its progression were also had actively connected with a 5-year collaborative European Culture project: âMetaBodyâ.
The research thus involves exploration of Interactive Architecture from the following perspectives: architectural design, digital architectural history trajectory, computational technology, philosophical discourse related to the embodiment, media and digital culture, current VR and body-related technology, and Evolutionary Developmental Biology. âHyperCellâ will encourage young architects to pursue interdisciplinary design initiatives via the fusion of computational design, embodiment, and biology for developing bio-inspired organic architectures
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