Can we <i>S</i>ave the rectum by watchful waiting or <i>T</i>rans<i>A</i>nal microsurgery following (chemo) <i>R</i>adiotherapy versus total mesorectal excision for early <i>RE</i>ctal <i>C</i>ancer (STAR-TREC study)?::protocol for a multicentre, randomised feasibility study

Introduction Total mesorectal excision (TME) is the highly effective standard treatment for rectal cancer but is associated with significant morbidity and may be overtreatment for low-risk cancers. This study is designed to determine the feasibility of international recruitment in a study comparing organ-saving approaches versus standard TME surgery. Methods and analysis STAR-TREC trial is a multicentre international randomised, three-arm parallel, phase II feasibility study in patients with biopsy-proven adenocarcinoma of the rectum. The trial is coordinated from Birmingham, UK with national hubs in Radboudumc (the Netherlands) and Odense University Hospital Svendborg UMC (Denmark). Patients with rectal cancer, staged by CT and MRI as ≤cT3b (up to 5 mm of extramural spread) N0 M0 can be included. Patients will be randomised to either standard TME surgery (control), organ-saving treatment using long-course concurrent chemoradiation or organ-saving treatment using short-course radiotherapy. For patients treated with an organ-saving strategy, clinical response to (chemo)radiotherapy determines the next treatment step. An active surveillance regime will be performed in the case of a complete clinical regression. In the case of incomplete clinical regression, patients will proceed to local excision using an optimised platform such as transanal endoscopic microsurgery or other transanal techniques (eg, transanal endoscopic operation or transanal minimally invasive surgery). The primary endpoint of this phase II study is to demonstrate sufficient international recruitment in order to sustain a phase III study incorporating pelvic failure as the primary endpoint. Success in phase II is defined as randomisation of at least four cases per month internationally in year 1, rising to at least six cases per month internationally during year 2

CRL at Ntcir2

We have developed systems of two types for NTCIR2. One is an enhenced version of the system we developed for NTCIR1 and IREX. It submitted retrieval results for JJ and CC tasks. A variety of parameters were tried with the system. It used such characteristics of newspapers as locational information in the CC tasks. The system got good results for both of the tasks. The other system is a portable system which avoids free parameters as much as possible. The system submitted retrieval results for JJ, JE, EE, EJ, and CC tasks. The system automatically determined the number of top documents and the weight of the original query used in automatic-feedback retrieval. It also determined relevant terms quite robustly. For EJ and JE tasks, it used document expansion to augment the initial queries. It achieved good results, except on the CC tasks.Comment: 11 pages. Computation and Language. This paper describes our results of information retrieval in the NTCIR2 contes

A Probabilistic Multimedia Retrieval Model and its Evaluation

We present a probabilistic model for the retrieval of multimodal documents. The model is based on Bayesian decision theory and combines models for text-based search with models for visual search. The textual model is based on the language modelling approach to text retrieval, and the visual information is modelled as a mixture of Gaussian densities. Both models have proved successful on various standard retrieval tasks. We evaluate the multimodal model on the search task of TREC′s video track. We found that the disclosure of video material based on visual information only is still too difficult. Even with purely visual information needs, text-based retrieval still outperforms visual approaches. The probabilistic model is useful for text, visual, and multimedia retrieval. Unfortunately, simplifying assumptions that reduce its computational complexity degrade retrieval effectiveness. Regarding the question whether the model can effectively combine information from different modalities, we conclude that whenever both modalities yield reasonable scores, a combined run outperforms the individual runs

A survey on the use of relevance feedback for information access systems

Users of online search engines often find it difficult to express their need for information in the form of a query. However, if the user can identify examples of the kind of documents they require then they can employ a technique known as relevance feedback. Relevance feedback covers a range of techniques intended to improve a user's query and facilitate retrieval of information relevant to a user's information need. In this paper we survey relevance feedback techniques. We study both automatic techniques, in which the system modifies the user's query, and interactive techniques, in which the user has control over query modification. We also consider specific interfaces to relevance feedback systems and characteristics of searchers that can affect the use and success of relevance feedback systems

The Coaxial L-P Cryogenic Receiver of the Sardinia Radio Telescope

The design and characterization of the coaxial dual-band L-P radio astronomical receiver for the prime focus of the Sardinia radio telescope are presented. The main feature of this receiver is to allow simultaneous radio astronomical observations in the P (305-410 MHz) and L (1.3-1.8 GHz) frequency bands. This functionality, which has been requested by the Pulsar research group at the National Institute for Astrophysics to estimate, among the others, the ionospheric dispersion in Pulsar observation, is currently missing in any other radio astronomical facility throughout the world. Also, single band operation is ensured by the proposed design both in linear and circular polarization, making this L-P receiver an ideal instrument for a wide range of radio astronomical and space applications. Some components of the receiver chain have been housed inside a cryostat and refrigerated at 20 K to reduce the noise temperature, resulting in a good performance compared to the receivers of other large radio telescopes. Several challenging issues have been faced in the design, mainly due to the large dimension and weight of the overall structure to be mounted in the prime focus position. Moreover, the design of the cryostat was constrained by the limited space available in the direction of the optical axis inside the focal cabin of the radio telescope, requiring a compact and light realization of the components of the receiver chain. This called for a home-made design of several devices, requiring a strong collaborative effort by researchers, engineers, and astronomers