Foundational principles for large scale inference: Illustrations through correlation mining

When can reliable inference be drawn in the "Big Data" context? This paper presents a framework for answering this fundamental question in the context of correlation mining, with implications for general large scale inference. In large scale data applications like genomics, connectomics, and eco-informatics the dataset is often variable-rich but sample-starved: a regime where the number $n$ of acquired samples (statistical replicates) is far fewer than the number $p$ of observed variables (genes, neurons, voxels, or chemical constituents). Much of recent work has focused on understanding the computational complexity of proposed methods for "Big Data." Sample complexity however has received relatively less attention, especially in the setting when the sample size $n$ is fixed, and the dimension $p$ grows without bound. To address this gap, we develop a unified statistical framework that explicitly quantifies the sample complexity of various inferential tasks. Sampling regimes can be divided into several categories: 1) the classical asymptotic regime where the variable dimension is fixed and the sample size goes to infinity; 2) the mixed asymptotic regime where both variable dimension and sample size go to infinity at comparable rates; 3) the purely high dimensional asymptotic regime where the variable dimension goes to infinity and the sample size is fixed. Each regime has its niche but only the latter regime applies to exa-scale data dimension. We illustrate this high dimensional framework for the problem of correlation mining, where it is the matrix of pairwise and partial correlations among the variables that are of interest. We demonstrate various regimes of correlation mining based on the unifying perspective of high dimensional learning rates and sample complexity for different structured covariance models and different inference tasks

Learning and comparing functional connectomes across subjects

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven experiments they represent integration mechanisms between specialized brain areas. Analyzing their variability across subjects and conditions can reveal markers of brain pathologies and mechanisms underlying cognition. Methods of estimating functional connectomes from the imaging signal have undergone rapid developments and the literature is full of diverse strategies for comparing them. This review aims to clarify links across functional-connectivity methods as well as to expose different steps to perform a group study of functional connectomes

Low-complexity Multiclass Encryption by Compressed Sensing

The idea that compressed sensing may be used to encrypt information from unauthorised receivers has already been envisioned, but never explored in depth since its security may seem compromised by the linearity of its encoding process. In this paper we apply this simple encoding to define a general private-key encryption scheme in which a transmitter distributes the same encoded measurements to receivers of different classes, which are provided partially corrupted encoding matrices and are thus allowed to decode the acquired signal at provably different levels of recovery quality. The security properties of this scheme are thoroughly analysed: firstly, the properties of our multiclass encryption are theoretically investigated by deriving performance bounds on the recovery quality attained by lower-class receivers with respect to high-class ones. Then we perform a statistical analysis of the measurements to show that, although not perfectly secure, compressed sensing grants some level of security that comes at almost-zero cost and thus may benefit resource-limited applications. In addition to this we report some exemplary applications of multiclass encryption by compressed sensing of speech signals, electrocardiographic tracks and images, in which quality degradation is quantified as the impossibility of some feature extraction algorithms to obtain sensitive information from suitably degraded signal recoveries.Comment: IEEE Transactions on Signal Processing, accepted for publication. Article in pres