258 research outputs found
Privacy in the Genomic Era
Genome sequencing technology has advanced at a rapid pace and it is now
possible to generate highly-detailed genotypes inexpensively. The collection
and analysis of such data has the potential to support various applications,
including personalized medical services. While the benefits of the genomics
revolution are trumpeted by the biomedical community, the increased
availability of such data has major implications for personal privacy; notably
because the genome has certain essential features, which include (but are not
limited to) (i) an association with traits and certain diseases, (ii)
identification capability (e.g., forensics), and (iii) revelation of family
relationships. Moreover, direct-to-consumer DNA testing increases the
likelihood that genome data will be made available in less regulated
environments, such as the Internet and for-profit companies. The problem of
genome data privacy thus resides at the crossroads of computer science,
medicine, and public policy. While the computer scientists have addressed data
privacy for various data types, there has been less attention dedicated to
genomic data. Thus, the goal of this paper is to provide a systematization of
knowledge for the computer science community. In doing so, we address some of
the (sometimes erroneous) beliefs of this field and we report on a survey we
conducted about genome data privacy with biomedical specialists. Then, after
characterizing the genome privacy problem, we review the state-of-the-art
regarding privacy attacks on genomic data and strategies for mitigating such
attacks, as well as contextualizing these attacks from the perspective of
medicine and public policy. This paper concludes with an enumeration of the
challenges for genome data privacy and presents a framework to systematize the
analysis of threats and the design of countermeasures as the field moves
forward
Exploring Privacy-Preserving Disease Diagnosis: A Comparative Analysis
In the healthcare sector, data is considered as a valuable asset, with enormous amounts generated in the form of patient records and disease-related information. Leveraging machine learning techniques enables the analysis of extensive datasets, unveiling hidden patterns in diseases, facilitating personalized treatments, and forecasting potential health issues. However, the flourish of online diagnosis and prediction still faces some challenges related to information security and privacy as disease diagnosis technologies utilizes a lot of clinical records and sensitive patient data. Hence, it becomes imperative to prioritize the development of innovative methodologies that not only advance the accuracy and efficiency of disease prediction but also ensure the highest standards of privacy protection. This requires collaborative efforts between researchers, healthcare practitioners, and policymakers to establish a comprehensive framework that addresses the evolving landscape of healthcare data while safeguarding individual privacy. Addressing this constraint, numerous researchers integrate privacy preservation measures with disease prediction techniques to develop a system capable of diagnosing diseases without compromising the confidentiality of sensitive information. The survey paper conducts a comparative analysis of privacy-preserving techniques employed in disease diagnosis and prediction. It explores existing methodologies across various domains, assessing their efficacy and trade-offs in maintaining data confidentiality while optimizing diagnostic accuracy. The review highlights the need for robust privacy measures in disease prediction, shortcomings related to existing techniques of privacy preserving disease diagnosis, and provides insights into promising directions for future research in this critical intersection of healthcare and privacy preservation
Privacy-Aware Architectures for NFC and RFID Sensors in Healthcare Applications
World population and life expectancy have increased steadily in recent years, raising issues regarding access to medical treatments and related expenses. Through last-generation medical sensors, NFC (Near Field Communication) and radio frequency identification (RFID) technologies can enable healthcare internet of things (H-IoT) systems to improve the quality of care while reducing costs. Moreover, the adoption of point-of-care (PoC) testing, performed whenever care is needed to return prompt feedback to the patient, can generate great synergy with NFC/RFID H-IoT systems. However, medical data are extremely sensitive and require careful management and storage to protect patients from malicious actors, so secure system architectures must be conceived for real scenarios. Existing studies do not analyze the security of raw data from the radiofrequency link to cloud-based sharing. Therefore, two novel cloud-based system architectures for data collected from NFC/RFID medical sensors are proposed in this paper. Privacy during data collection is ensured using a set of classical countermeasures selected based on the scientific literature. Then, data can be shared with the medical team using one of two architectures: in the first one, the medical system manages all data accesses, whereas in the second one, the patient defines the access policies. Comprehensive analysis of the H-IoT system can be useful for fostering research on the security of wearable wireless sensors. Moreover, the proposed architectures can be implemented for deploying and testing NFC/RFID-based healthcare applications, such as, for instance, domestic PoCs
Enhancing Confidentiality and Privacy Preservation in e-Health to Enhanced Security
Electronic health (e-health) system use is growing, which has improved healthcare services significantly but has created questions about the privacy and security of sensitive medical data. This research suggests a novel strategy to overcome these difficulties and strengthen the security of e-health systems while maintaining the privacy and confidentiality of patient data by utilising machine learning techniques. The security layers of e-health systems are strengthened by the comprehensive framework we propose in this paper, which incorporates cutting-edge machine learning algorithms. The suggested framework includes data encryption, access control, and anomaly detection as its three main elements. First, to prevent unauthorised access during transmission and storage, patient data is secured using cutting-edge encryption technologies. Second, to make sure that only authorised staff can access sensitive medical records, access control mechanisms are strengthened using machine learning models that examine user behaviour patterns. This research's inclusion of machine learning-based anomaly detection is its most inventive feature. The technology may identify variations from typical data access and usage patterns, thereby quickly spotting potential security breaches or unauthorised activity, by training models on past e-health data. This proactive strategy improves the system's capacity to successfully address new threats. Extensive experiments were carried out employing a broad dataset made up of real-world e-health scenarios to verify the efficacy of the suggested approach. The findings showed a marked improvement in the protection of confidentiality and privacy, along with a considerable decline in security breaches and unauthorised access events
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FlexFHE: A System for Homomorphically Encrypting DNA and Operating on Encrypted Data Securely in Untrusted Environments
DNA data contains sensitive health information and personally identifiable data. Currently, even if DNA data is stored in encrypted databases, it must be decrypted for health professionals and researchers to analyze, which means that DNA data exists in plaintext on unsecured, untrusted servers and machines during analysis. This thesis describes a complete system for homomorphically encrypting DNA data in a trusted context and then running analytic operations on the encrypted DNA data in an untrusted context, thus allowing healthcare professionals and researchers to run both high volume analytics on many individuals’ sequenced DNA and run complex analytics on a single individual’s sequenced DNA without ever handling plaintext data.
Symmetric encryption is used as a mechanism for controlling which queries are made on the data. The threat model addressed by this system allows an authorized party to run only authorized queries on a genome, while restricting any additional access.
The system implemented achieves substring search, substring search with wildcards representing mutations, and percent match between two nucleotide sequences by converting genomic data into one-hot binary matrixes and encrypting each bit individually using OpenFHE’s LWE Encryption implemented using the CGGI scheme. While runtime for each operation is O(nm), each operation is maximally parallelized using OpenMP, thus allowing for accelerated performance on machines with multiple CPUs without the need for batching
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