1,256 research outputs found
Linear response for spiking neuronal networks with unbounded memory
We establish a general linear response relation for spiking neuronal
networks, based on chains with unbounded memory. This relation allows us to
predict the influence of a weak amplitude time-dependent external stimuli on
spatio-temporal spike correlations, from the spontaneous statistics (without
stimulus) in a general context where the memory in spike dynamics can extend
arbitrarily far in the past. Using this approach, we show how linear response
is explicitly related to neuronal dynamics with an example, the gIF model,
introduced by M. Rudolph and A. Destexhe. This example illustrates the
collective effect of the stimuli, intrinsic neuronal dynamics, and network
connectivity on spike statistics. We illustrate our results with numerical
simulations.Comment: 60 pages, 8 figure
Synchronization and oscillatory dynamics in heterogeneous mutually inhibited neurons
We study some mechanisms responsible for synchronous oscillations and loss of
synchrony at physiologically relevant frequencies (10-200 Hz) in a network of
heterogeneous inhibitory neurons. We focus on the factors that determine the
level of synchrony and frequency of the network response, as well as the
effects of mild heterogeneity on network dynamics. With mild heterogeneity,
synchrony is never perfect and is relatively fragile. In addition, the effects
of inhibition are more complex in mildly heterogeneous networks than in
homogeneous ones. In the former, synchrony is broken in two distinct ways,
depending on the ratio of the synaptic decay time to the period of repetitive
action potentials (), where can be determined either from the
network or from a single, self-inhibiting neuron. With ,
corresponding to large applied current, small synaptic strength or large
synaptic decay time, the effects of inhibition are largely tonic and
heterogeneous neurons spike relatively independently. With ,
synchrony breaks when faster cells begin to suppress their less excitable
neighbors; cells that fire remain nearly synchronous. We show numerically that
the behavior of mildly heterogeneous networks can be related to the behavior of
single, self-inhibiting cells, which can be studied analytically.Comment: 17 pages, 6 figures, Kluwer.sty. Journal of Compuational Neuroscience
(in press). Originally submitted to the neuro-sys archive which was never
publicly announced (was 9802001
Locking of correlated neural activity to ongoing oscillations
Population-wide oscillations are ubiquitously observed in mesoscopic signals
of cortical activity. In these network states a global oscillatory cycle
modulates the propensity of neurons to fire. Synchronous activation of neurons
has been hypothesized to be a separate channel of signal processing information
in the brain. A salient question is therefore if and how oscillations interact
with spike synchrony and in how far these channels can be considered separate.
Experiments indeed showed that correlated spiking co-modulates with the static
firing rate and is also tightly locked to the phase of beta-oscillations. While
the dependence of correlations on the mean rate is well understood in
feed-forward networks, it remains unclear why and by which mechanisms
correlations tightly lock to an oscillatory cycle. We here demonstrate that
such correlated activation of pairs of neurons is qualitatively explained by
periodically-driven random networks. We identify the mechanisms by which
covariances depend on a driving periodic stimulus. Mean-field theory combined
with linear response theory yields closed-form expressions for the
cyclostationary mean activities and pairwise zero-time-lag covariances of
binary recurrent random networks. Two distinct mechanisms cause time-dependent
covariances: the modulation of the susceptibility of single neurons (via the
external input and network feedback) and the time-varying variances of single
unit activities. For some parameters, the effectively inhibitory recurrent
feedback leads to resonant covariances even if mean activities show
non-resonant behavior. Our analytical results open the question of
time-modulated synchronous activity to a quantitative analysis.Comment: 57 pages, 12 figures, published versio
Sparse Codes for Speech Predict Spectrotemporal Receptive Fields in the Inferior Colliculus
We have developed a sparse mathematical representation of speech that
minimizes the number of active model neurons needed to represent typical speech
sounds. The model learns several well-known acoustic features of speech such as
harmonic stacks, formants, onsets and terminations, but we also find more
exotic structures in the spectrogram representation of sound such as localized
checkerboard patterns and frequency-modulated excitatory subregions flanked by
suppressive sidebands. Moreover, several of these novel features resemble
neuronal receptive fields reported in the Inferior Colliculus (IC), as well as
auditory thalamus and cortex, and our model neurons exhibit the same tradeoff
in spectrotemporal resolution as has been observed in IC. To our knowledge,
this is the first demonstration that receptive fields of neurons in the
ascending mammalian auditory pathway beyond the auditory nerve can be predicted
based on coding principles and the statistical properties of recorded sounds.Comment: For Supporting Information, see PLoS website:
http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.100259
Dwelling Quietly in the Rich Club: Brain Network Determinants of Slow Cortical Fluctuations
For more than a century, cerebral cartography has been driven by
investigations of structural and morphological properties of the brain across
spatial scales and the temporal/functional phenomena that emerge from these
underlying features. The next era of brain mapping will be driven by studies
that consider both of these components of brain organization simultaneously --
elucidating their interactions and dependencies. Using this guiding principle,
we explored the origin of slowly fluctuating patterns of synchronization within
the topological core of brain regions known as the rich club, implicated in the
regulation of mood and introspection. We find that a constellation of densely
interconnected regions that constitute the rich club (including the anterior
insula, amygdala, and precuneus) play a central role in promoting a stable,
dynamical core of spontaneous activity in the primate cortex. The slow time
scales are well matched to the regulation of internal visceral states,
corresponding to the somatic correlates of mood and anxiety. In contrast, the
topology of the surrounding "feeder" cortical regions show unstable, rapidly
fluctuating dynamics likely crucial for fast perceptual processes. We discuss
these findings in relation to psychiatric disorders and the future of
connectomics.Comment: 35 pages, 6 figure
Phase synchronization of coupled bursting neurons and the generalized Kuramoto model
Bursting neurons fire rapid sequences of action potential spikes followed by
a quiescent period. The basic dynamical mechanism of bursting is the slow
currents that modulate a fast spiking activity caused by rapid ionic currents.
Minimal models of bursting neurons must include both effects. We considered one
of these models and its relation with a generalized Kuramoto model, thanks to
the definition of a geometrical phase for bursting and a corresponding
frequency. We considered neuronal networks with different connection topologies
and investigated the transition from a non-synchronized to a partially
phase-synchronized state as the coupling strength is varied. The numerically
determined critical coupling strength value for this transition to occur is
compared with theoretical results valid for the generalized Kuramoto model.Comment: 31 pages, 5 figure
Mixed-mode oscillations and interspike interval statistics in the stochastic FitzHugh-Nagumo model
We study the stochastic FitzHugh-Nagumo equations, modelling the dynamics of
neuronal action potentials, in parameter regimes characterised by mixed-mode
oscillations. The interspike time interval is related to the random number of
small-amplitude oscillations separating consecutive spikes. We prove that this
number has an asymptotically geometric distribution, whose parameter is related
to the principal eigenvalue of a substochastic Markov chain. We provide
rigorous bounds on this eigenvalue in the small-noise regime, and derive an
approximation of its dependence on the system's parameters for a large range of
noise intensities. This yields a precise description of the probability
distribution of observed mixed-mode patterns and interspike intervals.Comment: 36 page
Multiscale Computations on Neural Networks: From the Individual Neuron Interactions to the Macroscopic-Level Analysis
We show how the Equation-Free approach for multi-scale computations can be
exploited to systematically study the dynamics of neural interactions on a
random regular connected graph under a pairwise representation perspective.
Using an individual-based microscopic simulator as a black box coarse-grained
timestepper and with the aid of simulated annealing we compute the
coarse-grained equilibrium bifurcation diagram and analyze the stability of the
stationary states sidestepping the necessity of obtaining explicit closures at
the macroscopic level. We also exploit the scheme to perform a rare-events
analysis by estimating an effective Fokker-Planck describing the evolving
probability density function of the corresponding coarse-grained observables
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Acute silencing of hippocampal CA3 reveals a dominant role in place field responses.
Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased responses. These results imply that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealing heterogeneity in input dominance across cells
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