Host Restaurant Menu 2020

Host is like a chink of a much more cosmopolitan city shining through the suburban Dublin village of Ranelagh. They follow the winning neighbourhood formula of sharing plates, natural wine and sharply dressed staff, but the handmade pasta and general vibe that your wish is their command tip it over the edge. A Host in every neighbourhood would do much to alleviate the stresses of modern life.https://arrow.tudublin.ie/menus21c/1504/thumbnail.jp

Host-pathogen evolutionary signatures reveal dynamics and future invasions of vampire bat rabies

Anticipating how epidemics will spread across landscapes requires understanding host dispersal events that are notoriously difficult to measure. Here, we contrast host and virus genetic signatures to resolve the spatiotemporal dynamics underlying geographic expansions of vampire bat rabies virus (VBRV) in Peru. Phylogenetic analysis revealed recent viral spread between populations that, according to extreme geographic structure in maternally inherited host mitochondrial DNA, appeared completely isolated. In contrast, greater population connectivity in biparentally inherited nuclear microsatellites explained the historical limits of invasions, suggesting that dispersing male bats spread VBRV between genetically isolated female populations. Host nuclear DNA further indicated unanticipated gene flow through the Andes mountains connecting the VBRV-free Pacific coast to the VBRV-endemic Amazon rainforest. By combining Bayesian phylogeography with landscape resistance models, we projected invasion routes through northern Peru that were validated by real-time livestock rabies mortality data. The first outbreaks of VBRV on the Pacific coast of South America could occur by June 2020, which would have serious implications for agriculture, wildlife conservation, and human health. Our results show that combining host and pathogen genetic data can identify sex biases in pathogen spatial spread, which may be a widespread but underappreciated phenomenon, and demonstrate that genetic forecasting can aid preparedness for impending viral invasions

Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity

Type III secretion systems are used by many Gram-negative bacterial pathogens to inject proteins, known as effectors, into the cytosol of host cells. These virulence factors interfere with a diverse array of host signal transduction pathways and cellular processes. Many effectors have catalytic activities to promote post-translational modifications of host proteins. This review focuses on a family of effectors with glycosyltransferase activity that catalyze addition of N-acetyl-d-glucosamine to specific arginine residues in target proteins, leading to reduced NF-κB pathway activation and impaired host cell death. This family includes NleB from Citrobacter rodentium, NleB1 and NleB2 from enteropathogenic and enterohemorrhagic Escherichia coli, and SseK1, SseK2, and SseK3 from Salmonella enterica. First, we place these effectors in the general framework of the glycosyltransferase superfamily and in the particular context of the role of glycosylation in bacterial pathogenesis. Then, we provide detailed information about currently known members of this family, their role in virulence, and their targetsSpanish Ministerio de Economía, Industria y Competitividad , Agencia Estatal de Investigación, and the European Regional Development Fund, grant number SAF2016‐75365‐REuropean Union’s Horizon 2020 e Marie Skłodowska‐Curie grant agreement No 84262

Gauss and the Mathematical Background to Standardisation

Our aim is to explore the links between standardisation, the quantifying spirit, and the discipline mathematics. To do so, we consider the work of Gauss, renowned as a pure mathematician, but professionally an astronomer, and one heavily engaged with all kinds of measuring and precision initiatives. He contributed to the mathematical correction of data with the method of least squares; to observations of high precision in his geodetic work; to the introduction of absolute measures in his collaborations with Weber on terrestrial magnetism; and to the rationalisation of weights and measures in the state of Hannover. Ultimately, the question is to what extent such precision and standardisation activities may have been rooted in the mathematical way of thinking. Mathematics in our tradition has had a strong contemplative bias (theory, "theorein" in Greek means to contemplate), but it’s a fact that mathematics has always had a non-eliminable technical side.Ministerio de Economía y Competitividad (MINECO). España FFI2017-84524-PMinisterio de Economía y Competitividad (MINECO). España P12-HUM-121

Tiago Saraiva and Marta Macedo (eds.). Capital Científica. Práticas da Ciência em Lisboa e a História Contemporânea de Portugal

The investigations in the book Capital Científica. Práticas da Ciência em Lisboa e a História Contemporânea de Portugal (Scientific Capital. Practices of Science in Lisbon and the Contemporary History of Portugal) are the result of two projects conducted over the past few years at the Instituto de Ciências Sociais and the Centro Interuniversitário de História das Ciências e da Tecnologia on “The Spaces of Portuguese Technoscience (1837- 1947)” and “The Making of a Technoscientific Capital (1870-1940).” However, the book can also be read as a synthesis of the advances in the history of science and technology in Portugal during the last decades. This field of research has been particularly active, and the book demonstrates the maturity and the great coherence of historiographies in which the editors have occupied a central position, either in connection with urban history (Tiago Saraiva), or the history of the construction of the national state (Marta Macedo).BD11-B775-5469 | Frédéric Vidalinfo:eu-repo/semantics/publishedVersio

IIT-H to host CARRS 2020

Indian Institute of Technology-Hyderabad (IIT-H) will host an International Conference on Assessment, Rehabilitation and Retrofitting of Structures (CARRS) 2020 from December 14 to 16, 202

University Libraries News

University Libraries to Host DC SEUG 2020 Online Friday, May 2

Impactful learning: exploring the value of informal learning experiences to improve the learning potential of international research projects.

The Horizon 2020 (H2020) is the largest EU funded research programme, which supports mobility of international researchers through secondments to engage in collaborative research activities to enhance individual and collective research capacity within the EU. This paper explores how an analysis of secondees’ informal learning experiences can highlight opportunities for increasing individual and collective learning capacity of an international partnership and achievement of project objectives. A thematic analysis method (Miles and Huberman, 1994), was applied to 19 secondee’s individual learning reports. The main findings discussed three themes elicited through secondees informal learning, including living and working in a host country and developing an academic career. The paper outlines practice, policy and research implications for improving the learning potential of international research projects