A physical mechanism of heterogeneity in stem cell, cancer and cancer stem cell

Heterogeneity is ubiquitous in stem cells (SC), cancer cells (CS), and cancer stem cells (CSC). SC and CSC heterogeneity is manifested as diverse sub-populations with self-renewing and unique regeneration capacity. Moreover, the CSC progeny possesses multiple plasticity and cancerous characteristics. Many studies have demonstrated that cancer heterogeneity is one of the greatest obstacle for therapy. This leads to the incomplete anti-cancer therapies and transitory efficacy. Furthermore, numerous micro-metastasis leads to the wide spread of the tumor cells across the body which is the beginning of metastasis. The epigenetic processes (DNA methylation or histone remodification etc.) can provide a source for certain heterogeneity. In this study, we develop a mathematical model to quantify the heterogeneity of SC, CSC and cancer taking both genetic and epigenetic effects into consideration. We uncovered the roles and physical mechanisms of heterogeneity from the three aspects (SC, CSC and cancer). In the adiabatic regime (relatively fast regulatory binding and effective coupling among genes), seven native states (SC, CSC, Cancer, Premalignant, Normal, Lesion and Hyperplasia) emerge. In non-adiabatic regime (relatively slow regulatory binding and effective weak coupling among genes), multiple meta-stable SC, CS, CSC and differentiated states emerged which can explain the origin of heterogeneity. In other words, the slow regulatory binding mimicking the epigenetics can give rise to heterogeneity. Elucidating the origin of heterogeneity and dynamical interrelationship between intra-tumoral cells has clear clinical significance in helping to understand the cellular basis of treatment response, therapeutic resistance, and tumor relapse.Comment: 7 pages, 2 figure

The Heterogeneity of Implicit Bias

The term 'implicit bias' has very swiftly been incorporated into philosophical discourse. Our aim in this paper is to scrutinise the phenomena that fall under the rubric of implicit bias. The term is often used in a rather broad sense, to capture a range of implicit social cognitions, and this is useful for some purposes. However, we here articulate some of the important differences between phenomena identified as instances of implicit bias. We caution against ignoring these differences: it is likely they have considerable significance, not least for the sorts of normative recommendations being made concerning how to mitigate the bad effects of implicit bias

Heterogeneity of link weight and the evolution of cooperation

In this paper, we investigate the effect of "heterogeneity of link weight", heterogeneity of the frequency or amount of interactions among individuals, on the evolution of cooperation. Based on an analysis of the evolutionary prisoner's dilemma game on a weighted one-dimensional lattice network with "intra-individual heterogeneity", we confirm that moderate level of link-weight heterogeneity can facilitate cooperation. Furthermore, we identify two key mechanisms by which link-weight heterogeneity promotes the evolution of cooperation: mechanisms for spread and maintenance of cooperation. We also derive the corresponding conditions under which the mechanisms can work through evolutionary dynamics.Comment: 35 pages, 37 figures, Submitted to Physica

Estimating Learning Models with Experimental Data

We study the statistical properties of three estimation methods for a model of learning that is often tted to experimental data: quadratic deviation measures without unobserved heterogeneity, and maximum likelihood with and without unobserved heterogeneity. After discussing identi cation issues, we show that the estimators are consistent and provide their asymptotic distribution. Using Monte Carlo simulations, we show that ignoring unobserved heterogeneity can lead to seriously biased estimations in samples which have the typical length of actual experiments. Better small sample properties are obtained if unobserved heterogeneity is introduced. That is, rather than estimating the parameters for each individual, the individual parameters are considered random variables, and the distribution of those random variables is estimated

Electrocardiographic manifestation of cardiac repolarization dispersion

Alterations of repolarization heterogeneity in the heart have been established as anAlterations of repolarization heterogeneity in the heart have been established as a

Dynamic heterogeneity in amorphous materials

Amorphous solids are mechanically rigid while possessing a disordered structure similar to that of dense liquids. Recent research indicates that dynamical heterogeneity, spatio-temporal fluctuations in local dynamical behavior, might help understanding the statistical mechanics of glassy states.Comment: 7 pages; 5 figures -- "Trends" article published by Physics at http://physics.aps.org/articles/v4/4

Learning about heterogeneity in returns to schooling

Using data from the National Longitudinal Survey of Youth (NLSY) we introduce and estimate various Bayesian hierarchical models that investigate the nature of unobserved heterogeneity in returns to schooling. We consider a variety of possible forms for the heterogeneity, some motivated by previous theoretical and empirical work and some new ones, and let the data decide among the competing specifications. Empirical results indicate that heterogeneity is present in returns to education. Furthermore, we find strong evidence that the heterogeneity follows a continuous rather than a discrete distribution, and that bivariate normality provides a very reasonable description of individual-level heterogeneity in intercepts and returns to schooling