Editorial : living labs and user innovation (December 2015)

Welcome to the January 2016 issue of the Technology Innovation Management Review – the second of two issues on the theme of Living Labs and User Innovation. It is my pleasure welcome back our guest editors for December and January: Seppo Leminen (Laurea University of Applied Sciences and Aalto University, Finland), Dimitri Schuurman (iMinds and Ghent University, Belgium), Mika Westerlund (Carleton University, Canada), and Eelko Huizingh (University of Groningen, Netherlands)

Lifetime risk of prostate cancer overdiagnosis in Australia: Quantifying the risk of overdiagnosis associated with prostate cancer screening in Australia using a novel lifetime risk approach

© 2019 Author(s). Objectives To quantify the risk of overdiagnosis associated with prostate cancer screening in Australia using a novel lifetime risk approach. Design Modelling and validation of the lifetime risk method using publicly available population data. Setting Opportunistic screening for prostate cancer in the Australian population. Participants Australian male population (1982-2012). Interventions Prostate-specific antigen testing for prostate cancer screening. Primary and secondary outcome measures Primary: Lifetime risk of overdiagnosis in 2012 (excess lifetime cancer risk adjusted for changing competing mortality); Secondary: Lifetime risk of prostate cancer diagnosis (unadjusted and adjusted for competing mortality); Excess lifetime risk of prostate cancer diagnosis (for all years subsequent to 1982). Results The lifetime risk of being diagnosed with prostate cancer increased from 6.1% in 1982 (1 in 17) to 19.6% in 2012 (1 in 5). Using 2012 competing mortality rates, the lifetime risk in 1982 was 11.5% (95% CI 11.0% to 12.0%). The excess lifetime risk of prostate cancer in 2012 (adjusted for changing competing mortality) was 8.2% (95% CI 7.6% to 8.7%) (1 in 13). This corresponds to 41% of prostate cancers being overdiagnosed. Conclusions Our estimated rate of overdiagnosis is in agreement with estimates using other methods. This method may be used without the need to adjust for lead times. If annual (cross-sectional) data are used, then it may give valid estimates of overdiagnosis once screening has been established long enough for the benefits from the early detection of non-overdiagnosed cancer at a younger age to be realised in older age groups

VCU Media Lab

We propose the establishment of a VCU Media Lab – a professional creative media technology unit whose mission is to support the development, design, production and delivery of innovative media, multimedia, computer-based instruction, publications and tools in support of VCU education, research and marketing initiatives. This centrally administered, budgeted and resourced facility will acknowledge, refine, focus and expand media services that are currently being provided at VCU in a decentralized manner

Piezomorphic materials

The development of stress-induced morphing materials which are described as piezomorphic materials is reported. The development of a piezomorphic material is achieved by introducing spatial dependency into the compliance matrix describing the elastic response of a material capable of undergoing large strain deformation. In other words, it is necessary to produce an elastically gradient material. This is achieved through modification of the microstructure of the compliant material to display gradient topology. Examples of polymeric (polyurethane) foam and microporous polymer (expanded polytetrafluoroethylene) piezomorphic materials are presented here. These materials open up new morphing applications where dramatic shape changes can be triggered by mechanical stress

Engaging without over-powering: A case study of a FLOSS project

This is the post-print version of the published chapter. The original publication is available at the link below. Copyright @ 2010 IFIP International Federation for Information Processing.The role of Open Source Software (OSS) in the e-learning business has become more and more fundamental in the last 10 years, as long as corporate and government organizations have developed their educational and training programs based on OSS out-of-the-box tools. This paper qualitatively documents the decision of the largest UK e-learning provider, the Open University, to adopt the Moodle e-learning system, and how it has been successfully deployed in its site after a multi-million investment. A further quantitative study also provides evidence of how a commercial stakeholder has been engaged with, and produced outputs for, the Moodle community. Lessons learned from this experience by the stakeholders include the crucial factors of contributing to the OSS community, and adapting to an evolving technology. It also becomes evident how commercial partners helped this OSS system to achieve the transition from an “average” OSS system to a successful multi-site, collaborative and community-based OSS project

Change it Now: eBay v. MercExchange-Business Method Patent Litigation Reaches Critical Juncture Concerning Remedies for Infringement

Visual simultaneous localization and mapping (SLAM) as field has been researched for ten years, but with recent advances in mobile performance visual SLAM is entering the consumer market in a completely new way. A visual SLAM system will however be sensitive to non cautious use that may result in severe motion, occlusion or poor surroundings in terms of visual features that will cause the system to temporarily fail. The procedure of recovering from such a fail is called relocalization. Together with two similar problems localization, to find your position in an existing SLAM session, and loop closing, the online reparation and perfection of the map in an active SLAM session, these can be grouped as visual location recognition (VLR). This thesis presents novel results by combining the scalability of FabMap and the precision of 13th Lab's tracking yielding high-precision VLR, +/- 10 cm, while maintaining above 99 % precision and 60 % recall for sessions containing thousands of images. Everything functional purely on a normal mobile phone. The applications of VLR are many. Indoors, where GPS is not functioning, VLR can still provide positional information and navigate you through big complexes like airports and museums. Outdoors, VLR can improve the precision of GPS tenfold yielding a new level of navigational experience. Virtual and augmented reality applications are other areas that benefit from improved positioning and localization

Differential Impacts of Information Technology Services in the Korean Hotel Industry: A Study of Management Perceptions

Successful introduction of information technology applications in various operations of hotel management is vital to most service firms. In recent decades, technologies of information, automation, and communication are increasingly recognized as essential components of a hotel company’s strategic plan. In this study, 62 super-deluxe hotels (5 star), deluxe hotels (4 star), and tourist hotels (3 star) in Korea are examined for differences in the impact of information technology services on guest’ satisfaction, guest convenience, and operational efficiency. The findings generally suggest that the impacts of information technology-enhanced services vary according to the category of hotels in Korea. The results of the study are expected to assist managers in the selections and implementation of information technology systems in their hotel

Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells

We have previously shown that clusters of guanine quadruplex (G4) structures can form in the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and immune-electron microscopy with a G4-specific monoclonal antibody to visualize G4 structures in HSV-1 infected cells. We found that G4 formation and localization within the cells was virus cycle dependent: viral G4s peaked at the time of viral DNA replication in the cell nucleus, moved to the nuclear membrane at the time of virus nuclear egress and were later found in HSV-1 immature virions released from the cell nucleus. Colocalization of G4s with ICP8, a viral DNA processing protein, was observed in viral replication compartments. G4s were lost upon treatment with DNAse and inhibitors of HSV-1 DNA replication. The notable increase in G4s upon HSV-1 infection suggests a key role of these structures in the HSV-1 biology and indicates new targets to control both the lytic and latent infection