Goal-Oriented Mutation Testing with Focal Methods

Mutation testing is the state-of-the-art technique for assessing the fault-detection capacity of a test suite. Unfortunately, mutation testing consumes enormous computing resources because it runs the whole test suite for each and every injected mutant. In this paper we explore fine-grained traceability links at method level (named focal methods), to reduce the execution time of mutation testing and to verify the quality of the test cases for each individual method, instead of the usually verified overall test suite quality. Validation of our approach on the open source Apache Ant project shows a speed-up of 573.5x for the mutants located in focal methods with a quality score of 80%.Comment: A-TEST 201

A NASA-wide approach toward cost-effective, high-quality software through reuse

NASA Langley Research Center sponsored the second Workshop on NASA Research in Software Reuse on May 5-6, 1992 at the Research Triangle Park, North Carolina. The workshop was hosted by the Research Triangle Institute. Participants came from the three NASA centers, four NASA contractor companies, two research institutes and the Air Force's Rome Laboratory. The purpose of the workshop was to exchange information on software reuse tool development, particularly with respect to tool needs, requirements, and effectiveness. The participants presented the software reuse activities and tools being developed and used by their individual centers and programs. These programs address a wide range of reuse issues. The group also developed a mission and goals for software reuse within NASA. This publication summarizes the presentations and the issues discussed during the workshop

Effects of dance therapy on balance, gait and neuro-psychological performances in patients with Parkinson's disease and postural instability

Postural Instability (PI) is a core feature of Parkinson’s Disease (PD) and a major cause of falls and disabilities. Impairment of executive functions has been called as an aggravating factor on motor performances. Dance therapy has been shown effective for improving gait and has been suggested as an alternative rehabilitative method. To evaluate gait performance, spatial-temporal (S-T) gait parameters and cognitive performances in a cohort of patients with PD and PI modifications in balance after a cycle of dance therapy

Classifying the Correctness of Generated White-Box Tests: An Exploratory Study

White-box test generator tools rely only on the code under test to select test inputs, and capture the implementation's output as assertions. If there is a fault in the implementation, it could get encoded in the generated tests. Tool evaluations usually measure fault-detection capability using the number of such fault-encoding tests. However, these faults are only detected, if the developer can recognize that the encoded behavior is faulty. We designed an exploratory study to investigate how developers perform in classifying generated white-box test as faulty or correct. We carried out the study in a laboratory setting with 54 graduate students. The tests were generated for two open-source projects with the help of the IntelliTest tool. The performance of the participants were analyzed using binary classification metrics and by coding their observed activities. The results showed that participants incorrectly classified a large number of both fault-encoding and correct tests (with median misclassification rate 33% and 25% respectively). Thus the real fault-detection capability of test generators could be much lower than typically reported, and we suggest to take this human factor into account when evaluating generated white-box tests.Comment: 13 pages, 7 figure

Identification of integrin drug targets for 17 solid tumor types.

Integrins are contributors to remodeling of the extracellular matrix and cell migration. Integrins participate in the assembly of the actin cytoskeleton, regulate growth factor signaling pathways, cell proliferation, and control cell motility. In solid tumors, integrins are involved in promoting metastasis to distant sites, and angiogenesis. Integrins are a key target in cancer therapy and imaging. Integrin antagonists have proven successful in halting invasion and migration of tumors. Overexpressed integrins are prime anti-cancer drug targets. To streamline the development of specific integrin cancer therapeutics, we curated data to predict which integrin heterodimers are pausible therapeutic targets against 17 different solid tumors. Computational analysis of The Cancer Genome Atlas (TCGA) gene expression data revealed a set of integrin targets that are differentially expressed in tumors. Filtered by FPKM (Fragments Per Kilobase of transcript per Million mapped reads) expression level, overexpressed subunits were paired into heterodimeric protein targets. By comparing the RNA-seq differential expression results with immunohistochemistry (IHC) data, overexpressed integrin subunits were validated. Biologics and small molecule drug compounds against these identified overexpressed subunits and heterodimeric receptors are potential therapeutics against these cancers. In addition, high-affinity and high-specificity ligands against these integrins can serve as efficient vehicles for delivery of cancer drugs, nanotherapeutics, or imaging probes against cancer

Focal Spot, Spring 2009

https://digitalcommons.wustl.edu/focal_spot_archives/1111/thumbnail.jp