Искусственный интеллект при колоректальном раке: обзор

The study objective: the study objective is to examine the use of artificial intelligence (AI) in the diagnosis, treatment, and prognosis of Colorectal Cancer (CRC) and discuss the future potential of AI in CRC. Material and Methods. The Web of Science, Scopus, PubMed, Medline, and eLIBRARY databases were used to search for the publications. A study on the application of Artificial Intelligence (AI) to the diagnosis, treatment, and prognosis of Colorectal Cancer (CRC) was discovered in more than 100 sources. In the review, data from 83 articles were incorporated. Results. The review article explores the use of artificial intelligence (AI) in medicine, specifically focusing on its applications in colorectal cancer (CRC). It discusses the stages of AI development for CRC, including molecular understanding, image-based diagnosis, drug design, and individualized treatment. The benefits of AI in medical image analysis are highlighted, improving diagnosis accuracy and inspection quality. Challenges in AI development are addressed, such as data standardization and the interpretability of machine learning algorithms. The potential of AI in treatment decision support, precision medicine, and prognosis prediction is discussed, emphasizing the role of AI in selecting optimal treatments and improving surgical precision. Ethical and regulatory considerations in integrating AI are mentioned, including patient trust, data security, and liability in AI-assisted surgeries. The review emphasizes the importance of an AI standard system, dataset standardization, and integrating clinical knowledge into AI algorithms. Overall, the article provides an overview of the current research on AI in CRC diagnosis, treatment, and prognosis, discussing its benefits, challenges, and future prospects in improving medical outcomes.Цель исследования - оценка возможностей использования искусственного интеллекта (ИИ) в диагностике, лечении и прогнозировании колоректального рака (КРР), а также обсуждение потенциала ИИ в лечении КРР. Материал и методы. Проведен поиск научных публикаций в поисковых системах Web of Science, Scopus, PubMed, Medline и eLIBRARY. Было просмотрено более 100 источников по применению ИИ для диагностики, лечения и прогнозирования КРР. В обзор включены данные из 83 статей. Результаты. Проведен анализ литературы, посвященной применению искусственного интеллекта в медицине, особое внимание уделено его использованию при колоректальном раке. Обсуждаются этапы развития ИИ при КРР, включая молекулярную верификацию, лучевую диагностику, разработку лекарств и индивидуальное лечение. Подчеркнуты преимущества ИИ в анализе медицинских изображений, таких как КТ, МРТ и ПЭТ, что повышает точность диагностики. Рассматриваются такие проблемы развития ИИ, как стандартизация данных и интерпретируемость алгоритмов машинного обучения. Подчеркивается роль ИИ в выборе оптимальной тактики лечения и повышении эффективности хирургического вмешательства. Учитываются этические и нормативные аспекты ИИ, включая доверие пациентов, безопасность данных и ответственность в проведении операций с использованием ИИ. Обсуждаются преимущества ИИ в диагностике, лечении и прогнозировании колоректального рака, проблемы и перспективы улучшения результатов лечения

Multi-level feature fusion network combining attention mechanisms for polyp segmentation

Clinically, automated polyp segmentation techniques have the potential to significantly improve the efficiency and accuracy of medical diagnosis, thereby reducing the risk of colorectal cancer in patients. Unfortunately, existing methods suffer from two significant weaknesses that can impact the accuracy of segmentation. Firstly, features extracted by encoders are not adequately filtered and utilized. Secondly, semantic conflicts and information redundancy caused by feature fusion are not attended to. To overcome these limitations, we propose a novel approach for polyp segmentation, named MLFF-Net, which leverages multi-level feature fusion and attention mechanisms. Specifically, MLFF-Net comprises three modules: Multi-scale Attention Module (MAM), High-level Feature Enhancement Module (HFEM), and Global Attention Module (GAM). Among these, MAM is used to extract multi-scale information and polyp details from the shallow output of the encoder. In HFEM, the deep features of the encoders complement each other by aggregation. Meanwhile, the attention mechanism redistributes the weight of the aggregated features, weakening the conflicting redundant parts and highlighting the information useful to the task. GAM combines features from the encoder and decoder features, as well as computes global dependencies to prevent receptive field locality. Experimental results on five public datasets show that the proposed method not only can segment multiple types of polyps but also has advantages over current state-of-the-art methods in both accuracy and generalization ability

New applications of late fusion methods for EEG signal processing

[EN] Decision fusion consists in the combination of the outputs of multiple classifiers into a common decision that is more precise or stable. In most cases, however, only classical fusion techniques are considered. This work compares the performance of several state-of-the-art fusion methods on new applications of automatic stage classification of several neuropsychological tests. The tests were staged into three classes: stimulus display, retention interval, and subject response. The considered late fusion methods were: alpha integration; copulas; Dempster-Shafer combination; independent component analysis mixture models; and behavior knowledge space. Late fusion was able to improve the performance for the task, with alpha integration yielding the most stable result.This work was supported by Generalitat Valenciana under grant PROMETEO/2019/109 and Spanish Administration and European Union grant TEC2017-84743-P.Safont, G.; Salazar Afanador, A.; Vergara Domínguez, L. (2019). New applications of late fusion methods for EEG signal processing. IEEE. 617-621. https://doi.org/10.1109/CSCI49370.2019.00116S61762

Multi-scale and multi-spectral shape analysis: from 2d to 3d

Shape analysis is a fundamental aspect of many problems in computer graphics and computer vision, including shape matching, shape registration, object recognition and classification. Since the SIFT achieves excellent matching results in 2D image domain, it inspires us to convert the 3D shape analysis to 2D image analysis using geometric maps. However, the major disadvantage of geometric maps is that it introduces inevitable, large distortions when mapping large, complex and topologically complicated surfaces to a canonical domain. It is demanded for the researchers to construct the scale space directly on the 3D shape. To address these research issues, in this dissertation, in order to find the multiscale processing for the 3D shape, we start with shape vector image diffusion framework using the geometric mapping. Subsequently, we investigate the shape spectrum field by introducing the implementation and application of Laplacian shape spectrum. In order to construct the scale space on 3D shape directly, we present a novel idea to solve the diffusion equation using the manifold harmonics in the spectral point of view. Not only confined on the mesh, by using the point-based manifold harmonics, we rigorously derive our solution from the diffusion equation which is the essential of the scale space processing on the manifold. Built upon the point-based manifold harmonics transform, we generalize the diffusion function directly on the point clouds to create the scale space. In virtue of the multiscale structure from the scale space, we can detect the feature points and construct the descriptor based on the local neighborhood. As a result, multiscale shape analysis directly on the 3D shape can be achieved

An Automatic Gastrointestinal Polyp Detection System in Video Endoscopy Using Fusion of Color Wavelet and Convolutional Neural Network Features

Gastrointestinal polyps are considered to be the precursors of cancer development in most of the cases. Therefore, early detection and removal of polyps can reduce the possibility of cancer. Video endoscopy is the most used diagnostic modality for gastrointestinal polyps. But, because it is an operator dependent procedure, several human factors can lead to misdetection of polyps. Computer aided polyp detection can reduce polyp miss detection rate and assists doctors in finding the most important regions to pay attention to. In this paper, an automatic system has been proposed as a support to gastrointestinal polyp detection. This system captures the video streams from endoscopic video and, in the output, it shows the identified polyps. Color wavelet (CW) features and convolutional neural network (CNN) features of video frames are extracted and combined together which are used to train a linear support vector machine (SVM). Evaluations on standard public databases show that the proposed system outperforms the state-of-the-art methods, gaining accuracy of 98.65%, sensitivity of 98.79%, and specificity of 98.52%

Registration of prone and supine CT colonography images and its clinical application

Computed tomographic (CT) colonography is a technique for detecting bowel cancer and potentially precancerous polyps. CT imaging is performed on the cleansed and insufflated bowel in order to produce a virtual endoluminal representation similar to optical colonoscopy. Because fluids and stool can mimic pathology, images are acquired with the patient in both prone and supine positions. Radiologists then match endoluminal locations visually between the two acquisitions in order to determine whether pathology is real or not. This process is hindered by the fact that the colon can undergo considerable deformation between acquisitions. Robust and accurate automated registration between prone and supine data acquisitions is therefore pivotal for medical interpretation, but a challenging problem. The method proposed in this thesis reduces the complexity of the registration task of aligning the prone and supine CT colonography acquisitions. This is done by utilising cylindrical representations of the colonic surface which reflect the colon's specific anatomy. Automated alignment in the cylindrical domain is achieved by non-rigid image registration using surface curvatures, applicable even when cases exhibit local luminal collapses. It is furthermore shown that landmark matches for initialisation improve the registration's accuracy and robustness. Additional performance improvements are achieved by symmetric and inverse-consistent registration and iteratively deforming the surface in order to compensate for differences in distension and bowel preparation. Manually identified reference points in human data and fiducial markers in a porcine phantom are used to validate the registration accuracy. The potential clinical impact of the method has been evaluated using data that reflects clinical practise. Furthermore, correspondence between follow-up CT colonography acquisitions is established in order to facilitate the clinical need to investigate polyp growth over time. Accurate registration has the potential to both improve the diagnostic process and decrease the radiologist's interpretation time. Furthermore, its result could be integrated into algorithms for improved computer-aided detection of colonic polyps