Coq Modulo Theory - Short Paper

International audienceCoq Modulo Theory (CoqMT) is an extension of the Coq proof assistant incorporating, in its computational mechanism, validity entailment for user-defined first-order equational theories. Such a mechanism strictly enriches the system (more terms are typable), eases the use of dependent types and provides more automation during the development of proofs. CoqMT improves over the Calculus of Congruent Inductive Constructions by getting rid of various restrictions and simplifying the type-checking algorithm and the integration of first-order decision procedures

A Logic Programming Approach to Reaction Systems

Reaction systems (RS) are a computational framework inspired by the functioning of living cells, suitable to model the main mechanisms of biochemical reactions. RS have shown to be useful also for computer science applications, e.g. to model circuits or transition systems. Since their introduction about 10 years ago, RS matured into a fruitful and dynamically evolving research area. They have become a popular novel model of interactive computation. RS can be seen as a rewriting system interacting with the environment represented by the context. RS pose some problems of implementation, as it is a relatively recent computation model, and several extensions of the basic model have been designed. In this paper we present some preliminary work on how to implement this formalism in a logic programming language (Prolog). To the best of our knowledge this is the first approach to RS in logic programming. Our prototypical implementation does not aim to be highly performing, but has the advantage of being high level and easily modifiable. So it is suitable as a rapid prototyping tool for implementing several extensions of reaction systems in the literature as well as new ones. We also make a preliminary implementation of a kind of memoization mechanism for stopping potentially infinite and repetitive computations. Then we show how to implement in our interpreter an extension of RS for modeling a nondeterministic context and interaction between components of a (biological) system. We then present an extension of the interpreter for implementing the recently introduced networks of RS

Building Decision Procedures in the Calculus of Inductive Constructions

It is commonly agreed that the success of future proof assistants will rely on their ability to incorporate computations within deduction in order to mimic the mathematician when replacing the proof of a proposition P by the proof of an equivalent proposition P' obtained from P thanks to possibly complex calculations. In this paper, we investigate a new version of the calculus of inductive constructions which incorporates arbitrary decision procedures into deduction via the conversion rule of the calculus. The novelty of the problem in the context of the calculus of inductive constructions lies in the fact that the computation mechanism varies along proof-checking: goals are sent to the decision procedure together with the set of user hypotheses available from the current context. Our main result shows that this extension of the calculus of constructions does not compromise its main properties: confluence, subject reduction, strong normalization and consistency are all preserved

A Coverage Criterion for Spaced Seeds and its Applications to Support Vector Machine String Kernels and k-Mer Distances

Spaced seeds have been recently shown to not only detect more alignments, but also to give a more accurate measure of phylogenetic distances (Boden et al., 2013, Horwege et al., 2014, Leimeister et al., 2014), and to provide a lower misclassification rate when used with Support Vector Machines (SVMs) (On-odera and Shibuya, 2013), We confirm by independent experiments these two results, and propose in this article to use a coverage criterion (Benson and Mak, 2008, Martin, 2013, Martin and No{\'e}, 2014), to measure the seed efficiency in both cases in order to design better seed patterns. We show first how this coverage criterion can be directly measured by a full automaton-based approach. We then illustrate how this criterion performs when compared with two other criteria frequently used, namely the single-hit and multiple-hit criteria, through correlation coefficients with the correct classification/the true distance. At the end, for alignment-free distances, we propose an extension by adopting the coverage criterion, show how it performs, and indicate how it can be efficiently computed.Comment: http://online.liebertpub.com/doi/abs/10.1089/cmb.2014.017

A Coverage Criterion for Spaced Seeds and its Applications to Support Vector Machine String Kernels and k-Mer Distances

Spaced seeds have been recently shown to not only detect more alignments, but also to give a more accurate measure of phylogenetic distances (Boden et al., 2013, Horwege et al., 2014, Leimeister et al., 2014), and to provide a lower misclassification rate when used with Support Vector Machines (SVMs) (On-odera and Shibuya, 2013), We confirm by independent experiments these two results, and propose in this article to use a coverage criterion (Benson and Mak, 2008, Martin, 2013, Martin and No{\'e}, 2014), to measure the seed efficiency in both cases in order to design better seed patterns. We show first how this coverage criterion can be directly measured by a full automaton-based approach. We then illustrate how this criterion performs when compared with two other criteria frequently used, namely the single-hit and multiple-hit criteria, through correlation coefficients with the correct classification/the true distance. At the end, for alignment-free distances, we propose an extension by adopting the coverage criterion, show how it performs, and indicate how it can be efficiently computed.Comment: http://online.liebertpub.com/doi/abs/10.1089/cmb.2014.017