A bibliography on formal methods for system specification, design and validation

Literature on the specification, design, verification, testing, and evaluation of avionics systems was surveyed, providing 655 citations. Journal papers, conference papers, and technical reports are included. Manual and computer-based methods were employed. Keywords used in the online search are listed

Developing a distributed electronic health-record store for India

The DIGHT project is addressing the problem of building a scalable and highly available information store for the Electronic Health Records (EHRs) of the over one billion citizens of India

Towards a dynamic rule-based business process

IJWGS is now included in Science Citation Index Expanded (SCIE), starting from volume 4, 2008. The first impact factor, which will be for 2010, is expected to be published in mid 201

Organs on chip approach: A tool to evaluate cancer-immune cells interactions

In this paper we discuss the applicability of numerical descriptors and statistical physics concepts to characterize complex biological systems observed at microscopic level through organ on chip approach. To this end, we employ data collected on a micro uidic platform in which leukocytes can move through suitably built channels toward their target. Leukocyte behavior is recorded by standard time lapse imaging. In particular, we analyze three groups of human peripheral blood mononuclear cells (PBMC): heterozygous mutants (in which only one copy of the FPR1 gene is normal), homozygous mutants (in which both alleles encoding FPR1 are loss-of-function variants) and cells from ‘wild type’ donors (with normal expression of FPR1). We characterize the migration of these cells providing a quantitative con rmation of the essential role of FPR1 in cancer chemotherapy response. Indeed wild type PBMC perform biased random walks toward chemotherapy-treated cancer cells establishing persistent interactions with them. Conversely, heterozygous mutants present a weaker bias in their motion and homozygous mutants perform rather uncorrelated random walks, both failing to engage with their targets. We next focus on wild type cells and study the interactions of leukocytes with cancerous cells developing a novel heuristic procedure, inspired by Lyapunov stability in dynamical systems

Towards an HLA Run-time Infrastructure with Hard Real-time Capabilities

Our work takes place in the context of the HLA standard and its application in real-time systems context. The HLA standard is inadequate for taking into consideration the different constraints involved in real-time computer systems. Many works have been invested in order to providing real-time capabilities to Run Time Infrastructures (RTI) to run real time simulation. Most of these initiatives focus on major issues including QoS guarantee, Worst Case Transit Time (WCTT) knowledge and scheduling services provided by the underlying operating systems. Even if our ultimate objective is to achieve real-time capabilities for distributed HLA federations executions, this paper describes a preliminary work focusing on achieving hard real-time properties for HLA federations running on a single computer under Linux operating systems. Our paper proposes a novel global bottom up approach for designing real-time Run time Infrastructures and a formal model for validation of uni processor to (then) distributed real-time simulation with CERTI

The impact of local masses and inertias on the dynamic modelling of flexible manipulators

After a brief review of the recent literature dealing with flexible multi-body modelling for control design purpose, the paper first describes three different techniques used to build up the dynamic model of SECAFLEX, a 2 d.o.f. flexible in-plane manipulator driven by geared DC motors : introduction of local fictitious springs, use of a basis of assumed Euler-Bernouilli cantilever-free modes and of 5th order polynomial modes. This last technique allows to take easily into account local masses and inertias, which appear important in real-life experiments. Transformation of the state space models obtained in a common modal basis allows a quantitative comparison of the results obtained, while Bode plots of the various interesting transfer functions relating input torques to output in-joint and tip mea-surements give rather qualitative results. A parametric study of the effect of angular configuration changes and physical parameter modifications (including the effect of rotor inertia) shows that the three techniques give similar results up to the first flexible modes of each link when concentrated masses and inertias are present. From the control point of view, “pathological” cases are exhibited : uncertainty in the phase of the non-colocated transfer functions, high dependence of the free modes in the rotor inertia value. Robustness of the control to these kinds of uncertainties appears compulsory

Towards a new generation of transport services adapted to multimedia application

Une connexion d'ordre et de fiabilité partiels (POC, partial order connection) est une connexion de transport autorisée à perdre certains objets mais également à les délivrer dans un ordre éventuellement différent de celui d'émission. L'approche POC établit un lien conceptuel entre les protocoles sans connexion au mieux et les protocoles fiables avec connexion. Le concept de POC est motivé par le fait que dans les réseaux hétérogènes sans connexion tels qu'Internet, les paquets transmis sont susceptibles de se perdre et d'arriver en désordre, entraînant alors une réduction des performances des protocoles usuels. De plus, on montre qu'un protocole associé au transport d'un flux multimédia permet une réduction très sensible de l'utilisation des ressources de communication et de mémorisation ainsi qu'une diminution du temps de transit moyen. Dans cet article, une extension temporelle de POC, nommée TPOC (POC temporisé), est introduite. Elle constitue un cadre conceptuel permettant la prise en compte des exigences de qualité de service des applications multimédias réparties. Une architecture offrant un service TPOC est également introduite et évaluée dans le cadre du transport de vidéo MPEG. Il est ainsi démontré que les connexions POC comblent, non seulement le fossé conceptuel entre les protocoles sans connexion et avec connexion, mais aussi qu'ils surpassent les performances des ces derniers lorsque des données multimédias (telles que la vidéo MPEG) sont transportées