384 research outputs found
Deep Learning Paradigms for Existing and Imminent Lung Diseases Detection: A Review
Diagnosis of lung diseases like asthma, chronic obstructive pulmonary disease, tuberculosis, cancer, etc., by clinicians rely on images taken through various means like X-ray and MRI. Deep Learning (DL) paradigm has magnified growth in the medical image field in current years. With the advancement of DL, lung diseases in medical images can be efficiently identified and classified. For example, DL can detect lung cancer with an accuracy of 99.49% in supervised models and 95.3% in unsupervised models. The deep learning models can extract unattended features that can be effortlessly combined into the DL network architecture for better medical image examination of one or two lung diseases. In this review article, effective techniques are reviewed under the elementary DL models, viz. supervised, semi-supervised, and unsupervised Learning to represent the growth of DL in lung disease detection with lesser human intervention. Recent techniques are added to understand the paradigm shift and future research prospects. All three techniques used Computed Tomography (C.T.) images datasets till 2019, but after the pandemic period, chest radiographs (X-rays) datasets are more commonly used. X-rays help in the economically early detection of lung diseases that will save lives by providing early treatment. Each DL model focuses on identifying a few features of lung diseases. Researchers can explore the DL to automate the detection of more lung diseases through a standard system using datasets of X-ray images. Unsupervised DL has been extended from detection to prediction of lung diseases, which is a critical milestone to seek out the odds of lung sickness before it happens. Researchers can work on more prediction models identifying the severity stages of multiple lung diseases to reduce mortality rates and the associated cost. The review article aims to help researchers explore Deep Learning systems that can efficiently identify and predict lung diseases at enhanced accuracy
Explainable artificial intelligence (XAI) in deep learning-based medical image analysis
With an increase in deep learning-based methods, the call for explainability
of such methods grows, especially in high-stakes decision making areas such as
medical image analysis. This survey presents an overview of eXplainable
Artificial Intelligence (XAI) used in deep learning-based medical image
analysis. A framework of XAI criteria is introduced to classify deep
learning-based medical image analysis methods. Papers on XAI techniques in
medical image analysis are then surveyed and categorized according to the
framework and according to anatomical location. The paper concludes with an
outlook of future opportunities for XAI in medical image analysis.Comment: Submitted for publication. Comments welcome by email to first autho
Modeling Fission Gas Release at the Mesoscale using Multiscale DenseNet Regression with Attention Mechanism and Inception Blocks
Mesoscale simulations of fission gas release (FGR) in nuclear fuel provide a
powerful tool for understanding how microstructure evolution impacts FGR, but
they are computationally intensive. In this study, we present an alternate,
data-driven approach, using deep learning to predict instantaneous FGR flux
from 2D nuclear fuel microstructure images. Four convolutional neural network
(CNN) architectures with multiscale regression are trained and evaluated on
simulated FGR data generated using a hybrid phase field/cluster dynamics model.
All four networks show high predictive power, with values above 98%.
The best performing network combine a Convolutional Block Attention Module
(CBAM) and InceptionNet mechanisms to provide superior accuracy (mean absolute
percentage error of 4.4%), training stability, and robustness on very low
instantaneous FGR flux values.Comment: Submitted at Journal of Nuclear Materials, 20 pages, 10 figures, 3
table
Deep Learning in Medical Image Analysis
The accelerating power of deep learning in diagnosing diseases will empower physicians and speed up decision making in clinical environments. Applications of modern medical instruments and digitalization of medical care have generated enormous amounts of medical images in recent years. In this big data arena, new deep learning methods and computational models for efficient data processing, analysis, and modeling of the generated data are crucially important for clinical applications and understanding the underlying biological process. This book presents and highlights novel algorithms, architectures, techniques, and applications of deep learning for medical image analysis
Medical Image Segmentation Review: The success of U-Net
Automatic medical image segmentation is a crucial topic in the medical domain
and successively a critical counterpart in the computer-aided diagnosis
paradigm. U-Net is the most widespread image segmentation architecture due to
its flexibility, optimized modular design, and success in all medical image
modalities. Over the years, the U-Net model achieved tremendous attention from
academic and industrial researchers. Several extensions of this network have
been proposed to address the scale and complexity created by medical tasks.
Addressing the deficiency of the naive U-Net model is the foremost step for
vendors to utilize the proper U-Net variant model for their business. Having a
compendium of different variants in one place makes it easier for builders to
identify the relevant research. Also, for ML researchers it will help them
understand the challenges of the biological tasks that challenge the model. To
address this, we discuss the practical aspects of the U-Net model and suggest a
taxonomy to categorize each network variant. Moreover, to measure the
performance of these strategies in a clinical application, we propose fair
evaluations of some unique and famous designs on well-known datasets. We
provide a comprehensive implementation library with trained models for future
research. In addition, for ease of future studies, we created an online list of
U-Net papers with their possible official implementation. All information is
gathered in https://github.com/NITR098/Awesome-U-Net repository.Comment: Submitted to the IEEE Transactions on Pattern Analysis and Machine
Intelligence Journa
A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons
Computational models of disease progression have been constructed for a myriad of pathologies. Typically, the conceptual implementation for pathology-related in silico intervention studies has been ad hoc and similar in design to experimental studies. We introduce a multi-scale interventional design (MID) framework toward two key goals: tracking of disease dynamics from within-body to patient to population scale; and tracking impact(s) of interventions across these same spatial scales. Our MID framework prioritizes investigation of impact on individual patients within virtual pre-clinical trials, instead of replicating the design of experimental studies. We apply a MID framework to develop, organize, and analyze a cohort of virtual patients for the study of tuberculosis (TB) as an example disease. For this study, we use HostSim: our next-generation whole patient-scale computational model of individuals infected with Mycobacterium tuberculosis. HostSim captures infection within lungs by tracking multiple granulomas, together with dynamics occurring with blood and lymph node compartments, the compartments involved during pulmonary TB. We extend HostSim to include a simple drug intervention as an example of our approach and use our MID framework to quantify the impact of treatment at cellular and tissue (granuloma), patient (lungs, lymph nodes and blood), and population scales. Sensitivity analyses allow us to determine which features of virtual patients are the strongest predictors of intervention efficacy across scales. These insights allow us to identify patient-heterogeneous mechanisms that drive outcomes across scales
Networking Architecture and Key Technologies for Human Digital Twin in Personalized Healthcare: A Comprehensive Survey
Digital twin (DT), refers to a promising technique to digitally and
accurately represent actual physical entities. One typical advantage of DT is
that it can be used to not only virtually replicate a system's detailed
operations but also analyze the current condition, predict future behaviour,
and refine the control optimization. Although DT has been widely implemented in
various fields, such as smart manufacturing and transportation, its
conventional paradigm is limited to embody non-living entities, e.g., robots
and vehicles. When adopted in human-centric systems, a novel concept, called
human digital twin (HDT) has thus been proposed. Particularly, HDT allows in
silico representation of individual human body with the ability to dynamically
reflect molecular status, physiological status, emotional and psychological
status, as well as lifestyle evolutions. These prompt the expected application
of HDT in personalized healthcare (PH), which can facilitate remote monitoring,
diagnosis, prescription, surgery and rehabilitation. However, despite the large
potential, HDT faces substantial research challenges in different aspects, and
becomes an increasingly popular topic recently. In this survey, with a specific
focus on the networking architecture and key technologies for HDT in PH
applications, we first discuss the differences between HDT and conventional
DTs, followed by the universal framework and essential functions of HDT. We
then analyze its design requirements and challenges in PH applications. After
that, we provide an overview of the networking architecture of HDT, including
data acquisition layer, data communication layer, computation layer, data
management layer and data analysis and decision making layer. Besides reviewing
the key technologies for implementing such networking architecture in detail,
we conclude this survey by presenting future research directions of HDT
On Improving Generalization of CNN-Based Image Classification with Delineation Maps Using the CORF Push-Pull Inhibition Operator
Deployed image classification pipelines are typically dependent on the images captured in real-world environments. This means that images might be affected by different sources of perturbations (e.g. sensor noise in low-light environments). The main challenge arises by the fact that image quality directly impacts the reliability and consistency of classification tasks. This challenge has, hence, attracted wide interest within the computer vision communities. We propose a transformation step that attempts to enhance the generalization ability of CNN models in the presence of unseen noise in the test set. Concretely, the delineation maps of given images are determined using the CORF push-pull inhibition operator. Such an operation transforms an input image into a space that is more robust to noise before being processed by a CNN. We evaluated our approach on the Fashion MNIST data set with an AlexNet model. It turned out that the proposed CORF-augmented pipeline achieved comparable results on noise-free images to those of a conventional AlexNet classification model without CORF delineation maps, but it consistently achieved significantly superior performance on test images perturbed with different levels of Gaussian and uniform noise
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