A pilot study for the digital replacement of a distorted dentition acquired by Cone Beam Computed Tomography (CBCT)

Abstract Introduction: Cone beam CT (CBCT) is becoming a routine imaging modality designed for the maxillofacial region. Imaging patients with intra-oral metallic objects cause streak artefacts. Artefacts impair any virtual model by obliterating the teeth. This is a major obstacle for occlusal registration and the fabrication of orthognathic wafers to guide the surgical correction of dentofacial deformities. Aims and Objectives: To develop a method of replacing the inaccurate CBCT images of the dentition with an accurate representation and test the feasibility of the technique in the clinical environment. Materials and Method: Impressions of the teeth are acquired and acrylic baseplates constructed on dental casts incorporating radiopaque registration markers. The appliances are fitted and a preoperative CBCT is performed. Impressions are taken of the dentition with the devices in situ and subsequent dental models produced. The models are scanned to produce a virtual model. Both images of the patient and the model are imported into a virtual reality software program and aligned on the virtual markers. This allows the alignment of the dentition without relying on the teeth for superimposition. The occlusal surfaces of the dentition can be replaced with the occlusal image of the model. Results: The absolute mean distance of the mesh between the markers in the skulls was in the region of 0.09mm ± 0.03mm; the replacement dentition had an absolute mean distance of about 0.24mm ± 0.09mm. In patients the absolute mean distance between markers increased to 0.14mm ± 0.03mm. It was not possible to establish the discrepancies in the patient’s dentition, since the original image of the dentition is inherently inaccurate. Conclusion: It is possible to replace the CBCT virtual dentition of cadaveric skulls with an accurate representation to create a composite skull. The feasibility study was successful in the clinical arena. This could be a significant advancement in the accuracy of surgical prediction planning, with the ultimate goal of fabrication of a physical orthognathic wafer using reverse engineering

Ultra-High Field Strength MR Image-Guided Robotic Needle Delivery Device for In-Bore Small Animal Interventions

Current methods of accurate soft tissue injections in small animals are prone to many sources of error. Although efforts have been made to improve the accuracy of needle deliveries, none of the efforts have provided accurate soft tissue references. An MR image-guided robot was designed to function inside the bore of a 9.4T MR scanner to accurately deliver needles to locations within the mouse brain. The robot was designed to have no noticeable negative effects on the image quality and was localized in the MR images through the use of an MR image visible fiducial. The robot was mechanically calibrated and subsequently validated in an image-guided phantom experiment, where the mean needle targeting accuracy and needle trajectory accuracy were calculated to be 178 ± 54µm and 0.27 ± 0.65º, respectively. Finally, the device successfully demonstrated an image-guided needle targeting procedure in situ

Advanced Endoscopic Navigation:Surgical Big Data,Methodology,and Applications

随着科学技术的飞速发展，健康与环境问题日益成为人类面临的最重大问题之一。信息科学、计算机技术、电子工程与生物医学工程等学科的综合应用交叉前沿课题，研究现代工程技术方法，探索肿瘤癌症等疾病早期诊断、治疗和康复手段。本论文综述了计算机辅助微创外科手术导航、多模态医疗大数据、方法论及其临床应用：从引入微创外科手术导航概念出发，介绍了医疗大数据的术前与术中多模态医学成像方法、阐述了先进微创外科手术导航的核心流程包括计算解剖模型、术中实时导航方案、三维可视化方法及交互式软件技术，归纳了各类微创外科手术方法的临床应用。同时，重点讨论了全球各种手术导航技术在临床应用中的优缺点，分析了目前手术导航领域内的最新技术方法。在此基础上，提出了微创外科手术方法正向数字化、个性化、精准化、诊疗一体化、机器人化以及高度智能化的发展趋势。【Abstract】Interventional endoscopy (e.g., bronchoscopy, colonoscopy, laparoscopy, cystoscopy) is a widely performed procedure that involves either diagnosis of suspicious lesions or guidance for minimally invasive surgery in a variety of organs within the body cavity. Endoscopy may also be used to guide the introduction of certain items (e.g., stents) into the body. Endoscopic navigation systems seek to integrate big data with multimodal information (e.g., computed tomography, magnetic resonance images, endoscopic video sequences, ultrasound images, external trackers) relative to the patient's anatomy, control the movement of medical endoscopes and surgical tools, and guide the surgeon's actions during endoscopic interventions. Nevertheless, it remains challenging to realize the next generation of context-aware navigated endoscopy. This review presents a broad survey of various aspects of endoscopic navigation, particularly with respect to the development of endoscopic navigation techniques. First, we investigate big data with multimodal information involved in endoscopic navigation. Next, we focus on numerous methodologies used for endoscopic navigation. We then review different endoscopic procedures in clinical applications. Finally, we discuss novel techniques and promising directions for the development of endoscopic navigation.X.L. acknowledges funding from the Fundamental Research Funds for the Central Universities. T.M.P. acknowledges funding from the Canadian Foundation for Innovation, the Canadian Institutes for Health Research, the National Sciences and Engineering Research Council of Canada, and a grant from Intuitive Surgical Inc

Image-guided surgery and medical robotics in the cranial area

Surgery in the cranial area includes complex anatomic situations with high-risk structures and high demands for functional and aesthetic results. Conventional surgery requires that the surgeon transfers complex anatomic and surgical planning information, using spatial sense and experience. The surgical procedure depends entirely on the manual skills of the operator. The development of image-guided surgery provides new revolutionary opportunities by integrating presurgical 3D imaging and intraoperative manipulation. Augmented reality, mechatronic surgical tools, and medical robotics may continue to progress in surgical instrumentation, and ultimately, surgical care. The aim of this article is to review and discuss state-of-the-art surgical navigation and medical robotics, image-to-patient registration, aspects of accuracy, and clinical applications for surgery in the cranial area

Sub-pixel Registration In Computational Imaging And Applications To Enhancement Of Maxillofacial Ct Data

In computational imaging, data acquired by sampling the same scene or object at different times or from different orientations result in images in different coordinate systems. Registration is a crucial step in order to be able to compare, integrate and fuse the data obtained from different measurements. Tomography is the method of imaging a single plane or slice of an object. A Computed Tomography (CT) scan, also known as a CAT scan (Computed Axial Tomography scan), is a Helical Tomography, which traditionally produces a 2D image of the structures in a thin section of the body. It uses X-ray, which is ionizing radiation. Although the actual dose is typically low, repeated scans should be limited. In dentistry, implant dentistry in specific, there is a need for 3D visualization of internal anatomy. The internal visualization is mainly based on CT scanning technologies. The most important technological advancement which dramatically enhanced the clinician\u27s ability to diagnose, treat, and plan dental implants has been the CT scan. Advanced 3D modeling and visualization techniques permit highly refined and accurate assessment of the CT scan data. However, in addition to imperfections of the instrument and the imaging process, it is not uncommon to encounter other unwanted artifacts in the form of bright regions, flares and erroneous pixels due to dental bridges, metal braces, etc. Currently, removing and cleaning up the data from acquisition backscattering imperfections and unwanted artifacts is performed manually, which is as good as the experience level of the technician. On the other hand the process is error prone, since the editing process needs to be performed image by image. We address some of these issues by proposing novel registration methods and using stonecast models of patient\u27s dental imprint as reference ground truth data. Stone-cast models were originally used by dentists to make complete or partial dentures. The CT scan of such stone-cast models can be used to automatically guide the cleaning of patients\u27 CT scans from defects or unwanted artifacts, and also as an automatic segmentation system for the outliers of the CT scan data without use of stone-cast models. Segmented data is subsequently used to clean the data from artifacts using a new proposed 3D inpainting approach

Digital dental splints in orthognathic surgery and evaluation of their accuracy of fit in an anatomically articulated model

PURPOSE: The purpose of this prospective clinical study is to evaluate the accuracy of fit of digital dental splints in an anatomically articulated model on which model surgery is performed. The intermediate 3D printed splints were verified in an anatomical articulator. MATERIALS AND METHODS: A total of 4 patients (Table 1,2) who were willing to undergo orthognathic surgery (Graph 2) were included in this study. The methodology of the study were as follows: A Cone Beam Computed Tomography scan was obtained with fiducial titanium markers of standardized dimensions glued to the attached gingiva (Figure 57) for all patients excluding one patient for whom a medical Computed Tomography scan was taken. The upper and lower impressions were made, and models prepared (Figure 58). These dental casts were scanned with an optical scanner and the digital dental casts were saved as stl files (Figure 56 A, B). The CBCT scans and the digital dental scans were imported into MIMICS software (Version 17.0 Leuven, Belgium). Planned virtual osteotomy was performed virtually on the 3D reconstructed models after accurate superimposition based on the fiducial titanium markers (Figure 30,31). Intermediate splints were virtually designed (Figure 36,37,38), and 3D printed by importing into 3D printer (Inkjet printing) in our study. RESULTS: Out of the four patients, one patient with Hemifacial Microsomia had extensive bleeding during a medial cut on the mandibular ramus due to which the planned mandibular surgery was not performed. One patient was previously treated for temporomandibular joint ankylosis, who had no complications intra-operatively during orthognathic surgery. The fit of the digital dental splint was subjectively superior to the conventional acrylic splints and therefore was clinically more acceptable. CONCLUSION: The results of this study indicates that virtual planning and 3D printing of the intermediate splints have the following advantages: 1. An overall decrease in the time required for conventional planning in orthognathic surgery. 2. Aids in better understanding of the existing deformity in all dimensions. 3. Ensures more accuracy in splint fabrication, aiding in superior precision in positioning of the osteotomized segments. 4. Minimizes the errors due to conventional two-dimensional radiographs. 5. The use of fiducial markers in our study makes the superimposition process more accurate and avoids inaccuracies due to superimposition