Tracking the Temporal-Evolution of Supernova Bubbles in Numerical Simulations

The study of low-dimensional, noisy manifolds embedded in a higher dimensional space has been extremely useful in many applications, from the chemical analysis of multi-phase flows to simulations of galactic mergers. Building a probabilistic model of the manifolds has helped in describing their essential properties and how they vary in space. However, when the manifold is evolving through time, a joint spatio-temporal modelling is needed, in order to fully comprehend its nature. We propose a first-order Markovian process that propagates the spatial probabilistic model of a manifold at fixed time, to its adjacent temporal stages. The proposed methodology is demonstrated using a particle simulation of an interacting dwarf galaxy to describe the evolution of a cavity generated by a Supernov

Seventh International Workshop on Simulation, 21-25 May, 2013, Department of Statistical Sciences, Unit of Rimini, University of Bologna, Italy. Book of Abstracts

Seventh International Workshop on Simulation, 21-25 May, 2013, Department of Statistical Sciences, Unit of Rimini, University of Bologna, Italy. Book of Abstract

Advances in Robotics, Automation and Control

The book presents an excellent overview of the recent developments in the different areas of Robotics, Automation and Control. Through its 24 chapters, this book presents topics related to control and robot design; it also introduces new mathematical tools and techniques devoted to improve the system modeling and control. An important point is the use of rational agents and heuristic techniques to cope with the computational complexity required for controlling complex systems. Through this book, we also find navigation and vision algorithms, automatic handwritten comprehension and speech recognition systems that will be included in the next generation of productive systems developed by man

Toward adaptive radiotherapy

Intensity Modulated Radiotherapy (IMRT) and proton therapy are the state-of-art external radiotherapy modalities. To make the most of such precise delivery, accurate knowledge of the patient anatomy and biology during treatment is necessary, as unaccounted variations can compromise the outcome of the treatment. Treatment modification to account for deviations from the planning stage is a framework known as adaptive radiotherapy (ART). To fully utilise the information extracted from different modalities and/or at different time-points it is required to accurately align the imaging data. In this work the feasibility of cone-beam computed tomography (CBCT) and deformable image registration (DIR) for ART was evaluated in the context of head and neck (HN) and lung malignancies, and for IMRT and proton therapy applications. This included the geometric validation of deformations for multiple DIR algorithms, estimating the uncertainty in dose recalculation of a CBCT-based deformed CT (dCT), and the uncertainty in dose summation resulting from the properties of the underlying deformations. The dCT method was shown to be a good interim solution to repeat CT and a superior alternative to simpler direct usage of CBCT for dose calculation; proton therapy treatments were more sensitive to registration errors than IMRT. The ability to co-register multimodal and multitemporal data of the HN was also explored; the results found were promising and the limitations of current algorithms and data acquisition protocols were identified. The use of novel artificial cancer masses as a novel platform for the study of imaging during radiotherapy was explored in this study. The artificial cancer mass model was extended to generate magnetic resonance imaging (MRI)-friendly samples. The tumoroids were imageable in standard T1 and T2 MRI acquisitions, and the relaxometric properties were measured. The main limitation of the current tumour model was the poor reproducibility and controllability of the properties of the samples

Harnessing the power of GPUs for problems in real algebraic geometry

This thesis presents novel parallel algorithms to leverage the power of GPUs (Graphics Processing Units) for exact computations with polynomials having large integer coefficients. The significance of such computations, especially in real algebraic geometry, is hard to undermine. On massively-parallel architectures such as GPU, the degree of datalevel parallelism exposed by an algorithm is the main performance factor. We attain high efficiency through the use of structured matrix theory to assist the realization of relevant operations on polynomials on the graphics hardware. A detailed complexity analysis, assuming the PRAM model, also confirms that our approach achieves a substantially better parallel complexity in comparison to classical algorithms used for symbolic computations. Aside from the theoretical considerations, a large portion of this work is dedicated to the actual algorithm development and optimization techniques where we pay close attention to the specifics of the graphics hardware. As a byproduct of this work, we have developed high-throughput modular arithmetic which we expect to be useful for other GPU applications, in particular, open-key cryptography. We further discuss the algorithms for the solution of a system of polynomial equations, topology computation of algebraic curves and curve visualization which can profit to the full extent from the GPU acceleration. Extensive benchmarking on a real data demonstrates the superiority of our algorithms over several state-of-the-art approaches available to date. This thesis is written in English.Diese Arbeit beschäftigt sich mit neuen parallelen Algorithmen, die das Leistungspotenzial der Grafik-Prozessoren (GPUs) zur exakten Berechnungen mit ganzzahlige Polynomen nutzen. Solche symbolische Berechnungen sind von großer Bedeutung zur Lösung vieler Probleme aus der reellen algebraischen Geometrie. Für die effziente Implementierung eines Algorithmus auf massiv-parallelen Hardwarearchitekturen, wie z.B. GPU, ist vor allem auf eine hohe Datenparallelität zu achten. Unter Verwendung von Ergebnissen aus der strukturierten Matrix-Theorie konnten wir die entsprechenden Operationen mit Polynomen auf der Grafikkarte leicht übertragen. Außerdem zeigt eine Komplexitätanalyse im PRAM-Rechenmodell, dass die von uns entwickelten Verfahren eine deutlich bessere Komplexität aufweisen als dies für die klassischen Verfahren der Fall ist. Neben dem theoretischen Ergebnis liegt ein weiterer Schwerpunkt dieser Arbeit in der praktischen Implementierung der betrachteten Algorithmen, wobei wir auf der Besonderheiten der Grafikhardware achten. Im Rahmen dieser Arbeit haben wir hocheffiziente modulare Arithmetik entwickelt, von der wir erwarten, dass sie sich für andere GPU Anwendungen, insbesondere der Public-Key-Kryptographie, als nützlich erweisen wird. Darüber hinaus betrachten wir Algorithmen für die Lösung eines Systems von Polynomgleichungen, Topologie Berechnung der algebraischen Kurven und deren Visualisierung welche in vollem Umfang von der GPU-Leistung profitieren können. Zahlreiche Experimente belegen dass wir zur Zeit die beste Verfahren zur Verfügung stellen. Diese Dissertation ist in englischer Sprache verfasst

A comparison of the CAR and DAGAR spatial random effects models with an application to diabetics rate estimation in Belgium

When hierarchically modelling an epidemiological phenomenon on a finite collection of sites in space, one must always take a latent spatial effect into account in order to capture the correlation structure that links the phenomenon to the territory. In this work, we compare two autoregressive spatial models that can be used for this purpose: the classical CAR model and the more recent DAGAR model. Differently from the former, the latter has a desirable property: its ρ parameter can be naturally interpreted as the average neighbor pair correlation and, in addition, this parameter can be directly estimated when the effect is modelled using a DAGAR rather than a CAR structure. As an application, we model the diabetics rate in Belgium in 2014 and show the adequacy of these models in predicting the response variable when no covariates are available

A Statistical Approach to the Alignment of fMRI Data

Multi-subject functional Magnetic Resonance Image studies are critical. The anatomical and functional structure varies across subjects, so the image alignment is necessary. We define a probabilistic model to describe functional alignment. Imposing a prior distribution, as the matrix Fisher Von Mises distribution, of the orthogonal transformation parameter, the anatomical information is embedded in the estimation of the parameters, i.e., penalizing the combination of spatially distant voxels. Real applications show an improvement in the classification and interpretability of the results compared to various functional alignment methods