3D statistical shape analysis of the face in Apert syndrome

Timely diagnosis of craniofacial syndromes as well as adequate timing and choice of surgical technique are essential for proper care management. Statistical shape models and machine learning approaches are playing an increasing role in Medicine and have proven its usefulness. Frameworks that automate processes have become more popular. The use of 2D photographs for automated syndromic identification has shown its potential with the Face2Gene application. Yet, using 3D shape information without texture has not been studied in such depth. Moreover, the use of these models to understand shape change during growth and its applicability for surgical outcome measurements have not been analysed at length. This thesis presents a framework using state-of-the-art machine learning and computer vision algorithms to explore possibilities for automated syndrome identification based on shape information only. The purpose of this was to enhance understanding of the natural development of the Apert syndromic face and its abnormality as compared to a normative group. An additional method was used to objectify changes as result of facial bipartition distraction, a common surgical correction technique, providing information on the successfulness and on inadequacies in terms of facial normalisation. Growth curves were constructed to further quantify facial abnormalities in Apert syndrome over time along with 3D shape models for intuitive visualisation of the shape variations. Post-operative models were built and compared with age-matched normative data to understand where normalisation is coming short. The findings in this thesis provide markers for future translational research and may accelerate the adoption of the next generation diagnostics and surgical planning tools to further supplement the clinical decision-making process and ultimately to improve patients’ quality of life

Gender and Ethnicity Classification Using Partial Face in Biometric Applications

As the number of biometric applications increases, the use of non-ideal information such as images which are not strictly controlled, images taken covertly, or images where the main interest is partially occluded, also increases. Face images are a specific example of this. In these non-ideal instances, other information, such as gender and ethnicity, can be determined to narrow the search space and/or improve the recognition results. Some research exists for gender classification using partial-face images, but there is little research involving ethnic classifications on such images. Few datasets have had the ethnic diversity needed and sufficient subjects for each ethnicity to perform this evaluation. Research is also lacking on how gender and ethnicity classifications on partial face are impacted by age. If the extracted gender and ethnicity information is to be integrated into a larger system, some measure of the reliability of the extracted information is needed. This study will provide an analysis of gender and ethnicity classification on large datasets captured by non-researchers under day-to-day operations using texture, color, and shape features extracted from partial-face regions. This analysis will allow for a greater understanding of the limitations of various facial regions for gender and ethnicity classifications. These limitations will guide the integration of automatically extracted partial-face gender and ethnicity information with a biometric face application in order to improve recognition under non-ideal circumstances. Overall, the results from this work showed that reliable gender and ethnic classification can be achieved from partial face images. Different regions of the face hold varying amount of gender and ethnicity information. For machine classification, the upper face regions hold more ethnicity information while the lower face regions hold more gender information. All regions were impacted by age, but the eyes were impacted the most in texture and color. The shape of the nose changed more with respect to age than any of the other regions

Physical and statistical shape modelling in craniomaxillofacial surgery: a personalised approach for outcome prediction

Orthognathic surgery involves repositioning of the jaw bones to restore face function and shape for patients who require an operation as a result of a syndrome, due to growth disturbances in childhood or after trauma. As part of the preoperative assessment, three-dimensional medical imaging and computer-assisted surgical planning help to improve outcomes, and save time and cost. Computer-assisted surgical planning involves visualisation and manipulation of the patient anatomy and can be used to aid objective diagnosis, patient communication, outcome evaluation, and surgical simulation. Despite the benefits, the adoption of three-dimensional tools has remained limited beyond specialised hospitals and traditional two-dimensional cephalometric analysis is still the gold standard. This thesis presents a multidisciplinary approach to innovative surgical simulation involving clinical patient data, medical image analysis, engineering principles, and state-of-the-art machine learning and computer vision algorithms. Two novel three-dimensional computational models were developed to overcome the limitations of current computer-assisted surgical planning tools. First, a physical modelling approach – based on a probabilistic finite element model – provided patient-specific simulations and, through training and validation, population-specific parameters. The probabilistic model was equally accurate compared to two commercial programs whilst giving additional information regarding uncertainties relating to the material properties and the mismatch in bone position between planning and surgery. Second, a statistical modelling approach was developed that presents a paradigm shift in its modelling formulation and use. Specifically, a 3D morphable model was constructed from 5,000 non-patient and orthognathic patient faces for fully-automated diagnosis and surgical planning. Contrary to traditional physical models that are limited to a finite number of tests, the statistical model employs machine learning algorithms to provide the surgeon with a goal-driven patient-specific surgical plan. The findings in this thesis provide markers for future translational research and may accelerate the adoption of the next generation surgical planning tools to further supplement the clinical decision-making process and ultimately to improve patients’ quality of life

A comprehensive survey on Pose-Invariant Face Recognition

© 2016 ACM. The capacity to recognize faces under varied poses is a fundamental human ability that presents a unique challenge for computer vision systems. Compared to frontal face recognition, which has been intensively studied and has gradually matured in the past few decades, Pose-Invariant Face Recognition (PIFR) remains a largely unsolved problem. However, PIFR is crucial to realizing the full potential of face recognition for real-world applications, since face recognition is intrinsically a passive biometric technology for recognizing uncooperative subjects. In this article, we discuss the inherent difficulties in PIFR and present a comprehensive review of established techniques. Existing PIFR methods can be grouped into four categories, that is, pose-robust feature extraction approaches, multiview subspace learning approaches, face synthesis approaches, and hybrid approaches. The motivations, strategies, pros/cons, and performance of representative approaches are described and compared. Moreover, promising directions for future research are discussed

A study on different experimental configurations for age, race, and gender estimation problems

This paper presents a detailed study about different algorithmic configurations for estimating soft biometric traits. In particular, a recently introduced common framework is the starting point of the study: it includes an initial facial detection, the subsequent facial traits description, the data reduction step, and the final classification step. The algorithmic configurations are featured by different descriptors and different strategies to build the training dataset and to scale the data in input to the classifier. Experimental proofs have been carried out on both publicly available datasets and image sequences specifically acquired in order to evaluate the performance even under real-world conditions, i.e., in the presence of scaling and rotation

Unobtrusive and pervasive video-based eye-gaze tracking

Eye-gaze tracking has long been considered a desktop technology that finds its use inside the traditional office setting, where the operating conditions may be controlled. Nonetheless, recent advancements in mobile technology and a growing interest in capturing natural human behaviour have motivated an emerging interest in tracking eye movements within unconstrained real-life conditions, referred to as pervasive eye-gaze tracking. This critical review focuses on emerging passive and unobtrusive video-based eye-gaze tracking methods in recent literature, with the aim to identify different research avenues that are being followed in response to the challenges of pervasive eye-gaze tracking. Different eye-gaze tracking approaches are discussed in order to bring out their strengths and weaknesses, and to identify any limitations, within the context of pervasive eye-gaze tracking, that have yet to be considered by the computer vision community.peer-reviewe