DEVELOPMENT OF CYBER-PHYSICAL SYSTEM FOR LASER-BASED CONTROLLED CLOUD SEEDING

This research encompasses of developing a cyber-physical system (CPS) i.e., a system which can control the physical process of cloud formation by utilizing the LIDAR technology to modulate its frequency while directed on aerosol cloud in order to control the movement of cloud, formation and precipitation in a test bed settings. This will enable studying the detailed effects of laser induced cloud nucleation and also in modeling the cloud behavior with respect to the feedback loop between induced affect through lasers upon the aerosol cloud. This involves utilization of advanced algorithms, image processing techniques to model cloud behavior and artificial intelligence to control the laser frequency modulation and pulse count, directed or incidence angle to understand the response between laser effects on aerosol cloud. Â

Distributional constraints on cognitive architecture

Mental chronometry is a classical paradigm in cognitive psychology that uses response time and accuracy data in perceptual-motor tasks to elucidate the architecture and mechanisms of the underlying cognitive processes of human decisions. The redundant signals paradigm investigates the response behavior in Experimental tasks, where an integration of signals is required for a successful performance. The common finding is that responses are speeded for the redundant signals condition compared to single signals conditions. On a mean level, this redundant signals effect can be accounted for by several cognitive architectures, exhibiting considerable model mimicry. Jeff Miller formalized the maximum speed-up explainable by separate activations or race models in form of a distributional bound – the race model inequality. Whenever data violates this bound, it excludes race models as a viable account for the redundant signals effect. The common alternative is a coactivation account, where the signals integrate at some stage in the processing. Coactivation models have mostly been inferred on and rarely explicated though. Where coactivation is explicitly modeled, it is assumed to have a decisional locus. However, in the literature there are indications that coactivation might have at least a partial locus (if not entirely) in the nondecisional or motor stage. There are no studies that have tried to compare the fit of these coactivation variants to empirical data to test different effect generating loci. Ever since its formulation, the race model inequality has been used as a test to infer the cognitive architecture for observers’ performance in redundant signals Experiments. Subsequent theoretical and empirical analyses of this RMI test revealed several challenges. On the one hand, it is considered to be a conservative test, as it compares data to the maximum speed-up possible by a race model account. Moreover, simulation studies could show that the base time component can further reduce the power of the test, as violations are filtered out when this component has a high variance. On the other hand, another simulation study revealed that the common practice of RMI test can introduce an estimation bias, that effectively facilitates violations and increases the type I error of the test. Also, as the RMI bound is usually tested at multiple points of the same data, an inflation of type I errors can reach a substantial amount. Due to the lack of overlap in scope and the usage of atheoretic, descriptive reaction time models, the degree to which these results can be generalized is limited. State-of-the-art models of decision making provide a means to overcome these limitations and implement both race and coactivation models in order to perform large scale simulation studies. By applying a state-of-the-art model of decision making (scilicet the Ratcliff diffusion model) to the investigation of the redundant signals effect, the present study addresses research questions at different levels. On a conceptual level, it raises the question, at what stage coactivation occurs – at a decisional, a nondecisional or a combined decisional and nondecisional processing stage and to what extend? To that end, two bimodal detection tasks have been conducted. As the reaction time data exhibits violations of the RMI at multiple time points, it provides the basis for a comparative fitting analysis of coactivation model variants, representing different loci of the effect. On a test theoretic level, the present study integrates and extends the scopes of previous studies within a coherent simulation framework. The effect of experimental and statistical parameters on the performance of the RMI test (in terms of type I errors, power rates and biases) is analyzed via Monte Carlo simulations. Specifically, the simulations treated the following questions: (i) what is the power of the RMI test, (ii) is there an estimation bias for coactivated data as well and if so, in what direction, (iii) what is the effect of a highly varying base time component on the estimation bias, type I errors and power rates, (iv) and are the results of previous simulation studies (at least qualitatively) replicable, when current models of decision making are used for the reaction time generation. For this purpose, the Ratcliff diffusion model was used to implement race models with controllable amount of correlation and coactivation models with varying integration strength, and independently specifying the base time component. The results of the fitting suggest that for the two bimodal detection tasks, coactivation has a shared decisional and nondecisional locus. For the focused attention experiment the decisional part prevails, whereas in the divided attention task the motor component is dominating the redundant signals effect. The simulation study could reaffirm the conservativeness of the RMI test as latent coactivation is frequently missed. An estimation bias was found also for coactivated data however, both biases become negligible once more than 10 samples per condition are taken to estimate the respective distribution functions. A highly varying base time component reduces both the type I errors and the power of the test, while not affecting the estimation biases. The outcome of the present study has theoretical and practical implications for the investigations of decisions in a multisignal context. Theoretically, it contributes to the locus question of coactivation and offers evidence for a combined decisional and nondecisional coactivation account. On a practical level, the modular simulation approach developed in the present study enables researchers to further investigate the RMI test within a coherent and theoretically grounded framework. It effectively provides a means to optimally set up the RMI test and thus helps to solidify and substantiate its outcomes. On a conceptual level the present study advocates the application of current formal models of decision making to the mental chronometry paradigm and develops future research questions in the field of the redundant signals paradigm

Guiding object recognition: a shape model with co-activation networks

The goal of image understanding research is to develop techniques to automatically extract meaningful information from a population of images. This abstract goal manifests itself in a variety of application domains. Video understanding is a natural extension of image understanding. Many video understanding algorithms apply static-image algorithms to successive frames to identify patterns of consistency. This consumes a significant amount of irrelevant computation and may have erroneous results because static algorithms are not designed to indicate corresponding pixel locations between frames. Video is more than a collection of images, it is an ordered collection of images that exhibits temporal coherence, which is an additional feature like edges, colors, and textures. Motion information provides another level of visual information that can not be obtained from an isolated image. Leveraging motion cues prevents an algorithm from ?starting fresh? at each frame by focusing the region of attention. This approach is analogous to the attentional system of the human visual system. Relying on motion information alone is insufficient due to the aperture problem, where local motion information is ambiguous in at least one direction. Consequently, motion cues only provide leading and trailing motion edges and bottom-up approaches using gradient or region properties to complete moving regions are limited. Object recognition facilitates higher-level processing and is an integral component of image understanding. We present a components-based object detection and localization algorithm for static images. We show how this same system provides top-down segmentation for the detected object. We present a detailed analysis of the model dynamics during the localization process. This analysis shows consistent behavior in response to a variety of input, permitting model reduction and a substantial speed increase with little or no performance degradation. We present four specific enhancements to reduce false positives when instances of the target category are not present. First, a one-shot rule is used to discount coincident secondary hypotheses. Next, we demonstrate that the use of an entire shape model is inappropriate to localize any single instance and introduce the use of co-activation networks to represent the appropriate component relations for a particular recognition context. Next, we describe how the co-activation network can be combined with motion cues to overcome the aperture problem by providing context-specific, top-down shape information to achieve detection and segmentation in video. Finally, we present discriminating features arising from these enhancements and apply supervised learning techniques to embody the informational contribution of each approach to associate a confidence measure with each detection

Association Patterns of Ontological Features Signify Electronic Health Records in Liver Cancer

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Principal component analysis of ensemble recordings reveals cell assemblies at high temporal resolution

Simultaneous recordings of many single neurons reveals unique insights into network processing spanning the timescale from single spikes to global oscillations. Neurons dynamically self-organize in subgroups of coactivated elements referred to as cell assemblies. Furthermore, these cell assemblies are reactivated, or replayed, preferentially during subsequent rest or sleep episodes, a proposed mechanism for memory trace consolidation. Here we employ Principal Component Analysis to isolate such patterns of neural activity. In addition, a measure is developed to quantify the similarity of instantaneous activity with a template pattern, and we derive theoretical distributions for the null hypothesis of no correlation between spike trains, allowing one to evaluate the statistical significance of instantaneous coactivations. Hence, when applied in an epoch different from the one where the patterns were identified, (e.g. subsequent sleep) this measure allows to identify times and intensities of reactivation. The distribution of this measure provides information on the dynamics of reactivation events: in sleep these occur as transients rather than as a continuous process

Distributional constraints on cognitive architecture

Mental chronometry is a classical paradigm in cognitive psychology that uses response time and accuracy data in perceptual-motor tasks to elucidate the architecture and mechanisms of the underlying cognitive processes of human decisions. The redundant signals paradigm investigates the response behavior in Experimental tasks, where an integration of signals is required for a successful performance. The common finding is that responses are speeded for the redundant signals condition compared to single signals conditions. On a mean level, this redundant signals effect can be accounted for by several cognitive architectures, exhibiting considerable model mimicry. Jeff Miller formalized the maximum speed-up explainable by separate activations or race models in form of a distributional bound – the race model inequality. Whenever data violates this bound, it excludes race models as a viable account for the redundant signals effect. The common alternative is a coactivation account, where the signals integrate at some stage in the processing. Coactivation models have mostly been inferred on and rarely explicated though. Where coactivation is explicitly modeled, it is assumed to have a decisional locus. However, in the literature there are indications that coactivation might have at least a partial locus (if not entirely) in the nondecisional or motor stage. There are no studies that have tried to compare the fit of these coactivation variants to empirical data to test different effect generating loci. Ever since its formulation, the race model inequality has been used as a test to infer the cognitive architecture for observers’ performance in redundant signals Experiments. Subsequent theoretical and empirical analyses of this RMI test revealed several challenges. On the one hand, it is considered to be a conservative test, as it compares data to the maximum speed-up possible by a race model account. Moreover, simulation studies could show that the base time component can further reduce the power of the test, as violations are filtered out when this component has a high variance. On the other hand, another simulation study revealed that the common practice of RMI test can introduce an estimation bias, that effectively facilitates violations and increases the type I error of the test. Also, as the RMI bound is usually tested at multiple points of the same data, an inflation of type I errors can reach a substantial amount. Due to the lack of overlap in scope and the usage of atheoretic, descriptive reaction time models, the degree to which these results can be generalized is limited. State-of-the-art models of decision making provide a means to overcome these limitations and implement both race and coactivation models in order to perform large scale simulation studies. By applying a state-of-the-art model of decision making (scilicet the Ratcliff diffusion model) to the investigation of the redundant signals effect, the present study addresses research questions at different levels. On a conceptual level, it raises the question, at what stage coactivation occurs – at a decisional, a nondecisional or a combined decisional and nondecisional processing stage and to what extend? To that end, two bimodal detection tasks have been conducted. As the reaction time data exhibits violations of the RMI at multiple time points, it provides the basis for a comparative fitting analysis of coactivation model variants, representing different loci of the effect. On a test theoretic level, the present study integrates and extends the scopes of previous studies within a coherent simulation framework. The effect of experimental and statistical parameters on the performance of the RMI test (in terms of type I errors, power rates and biases) is analyzed via Monte Carlo simulations. Specifically, the simulations treated the following questions: (i) what is the power of the RMI test, (ii) is there an estimation bias for coactivated data as well and if so, in what direction, (iii) what is the effect of a highly varying base time component on the estimation bias, type I errors and power rates, (iv) and are the results of previous simulation studies (at least qualitatively) replicable, when current models of decision making are used for the reaction time generation. For this purpose, the Ratcliff diffusion model was used to implement race models with controllable amount of correlation and coactivation models with varying integration strength, and independently specifying the base time component. The results of the fitting suggest that for the two bimodal detection tasks, coactivation has a shared decisional and nondecisional locus. For the focused attention experiment the decisional part prevails, whereas in the divided attention task the motor component is dominating the redundant signals effect. The simulation study could reaffirm the conservativeness of the RMI test as latent coactivation is frequently missed. An estimation bias was found also for coactivated data however, both biases become negligible once more than 10 samples per condition are taken to estimate the respective distribution functions. A highly varying base time component reduces both the type I errors and the power of the test, while not affecting the estimation biases. The outcome of the present study has theoretical and practical implications for the investigations of decisions in a multisignal context. Theoretically, it contributes to the locus question of coactivation and offers evidence for a combined decisional and nondecisional coactivation account. On a practical level, the modular simulation approach developed in the present study enables researchers to further investigate the RMI test within a coherent and theoretically grounded framework. It effectively provides a means to optimally set up the RMI test and thus helps to solidify and substantiate its outcomes. On a conceptual level the present study advocates the application of current formal models of decision making to the mental chronometry paradigm and develops future research questions in the field of the redundant signals paradigm

Right Neural Substrates of Language and Music Processing Left Out: Activation Likelihood Estimation (ALE) and Meta-Analytic Connectivity Modelling (MACM)

Introduction: Language and music processing have been investigated in neuro-based research for over a century. However, consensus of independent and shared neural substrates among the domains remains elusive due to varying neuroimaging methodologies. Identifying functional connectivity in language and music processing via neuroimaging meta-analytic methods provides neuroscientific knowledge of higher cognitive domains and normative models may guide treatment development in communication disorders based on principles of neural plasticity. Methods: Using BrainMap software and tools, the present coordinate-based meta-analysis analyzed 65 fMRI studies investigating language and music processing in healthy adult subjects. We conducted activation likelihood estimates (ALE) in language processing, music processing, and language + music (Omnibus) processing. Omnibus ALE clusters were used to elucidate functional connectivity by use of meta-analytic connectivity modelling (MACM). Paradigm Class and Behavioral Domain analyses were completed for the ten identified nodes to aid functional MACM interpretation. Results: The Omnibus ALE revealed ten peak activation clusters (bilateral inferior frontal gyri, left medial frontal gyrus, right superior temporal gyrus, left transverse temporal gyrus, bilateral claustrum, left superior parietal lobule, right precentral gyrus, and right anterior culmen). MACM demonstrates an interconnected network consisting of unidirectional and bidirectional connectivity. Subsequent analyses demonstrated nodal involvement across 44 BrainMap paradigms and 32 BrainMap domains. Discussion: These findings demonstrate functional connectivity among Omnibus areas of activation in language and music processing. We analyze ALE and MACM outcomes by comparing them to previously observed roles in cognitive processing and functional network connectivity. Finally, we discuss the importance of translational neuroimaging and need for normative models guiding intervention

Embodied learning of a generative neural model for biological motion perception and inference

Although an action observation network and mirror neurons for understanding the actions and intentions of others have been under deep, interdisciplinary consideration over recent years, it remains largely unknown how the brain manages to map visually perceived biological motion of others onto its own motor system. This paper shows how such a mapping may be established, even if the biologically motion is visually perceived from a new vantage point. We introduce a learning artificial neural network model and evaluate it on full body motion tracking recordings. The model implements an embodied, predictive inference approach. It first learns to correlate and segment multimodal sensory streams of own bodily motion. In doing so, it becomes able to anticipate motion progression, to complete missing modal information, and to self-generate learned motion sequences. When biological motion of another person is observed, this self-knowledge is utilized to recognize similar motion patterns and predict their progress. Due to the relative encodings, the model shows strong robustness in recognition despite observing rather large varieties of body morphology and posture dynamics. By additionally equipping the model with the capability to rotate its visual frame of reference, it is able to deduce the visual perspective onto the observed person, establishing full consistency to the embodied self-motion encodings by means of active inference. In further support of its neuro-cognitive plausibility, we also model typical bistable perceptions when crucial depth information is missing. In sum, the introduced neural model proposes a solution to the problem of how the human brain may establish correspondence between observed bodily motion and its own motor system, thus offering a mechanism that supports the development of mirror neurons