Inventory drivers in a pharmaceutical supply chain

In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent markets-, high service levels, and complex, perishable finished-good portfolios, which makes keeping reasonable amounts of stock a true challenge. However, a one-way strategy towards zero-inventory is in reality inapplicable, due to the strategic nature and importance of the products being commercialised. Therefore, pharmaceutical supply chains are in need of new inventory strategies in order to remain competitive. Finished-goods inventory management in the pharmaceutical industry is closely related to the manufacturing systems and supply chain configurations that companies adopt. The factors considered in inventory management policies, however, do not always cover the full supply chain spectrum in which companies operate. This paper works under the pre-assumption that, in fact, there is a complex relationship between the inventory configurations that companies adopt and the factors behind them. The intention of this paper is to understand the factors driving high finished-goods inventory levels in pharmaceutical supply chains and assist supply chain managers in determining which of them can be influenced in order to reduce inventories to an optimal degree. Reasons for reducing inventory levels are found in high inventory holding and scrap related costs; in addition to lost sales for not being able to serve the customers with the adequate shelf life requirements. The thesis conducts a single case study research in a multi-national pharmaceutical company, which is used to examine typical inventory configurations and the factors affecting these configurations. This paper presents a framework that can assist supply chain managers in determining the most important inventory drivers in pharmaceutical supply chains. The findings in this study suggest that while external and downstream supply chain factors are recognized as being critical to pursue inventory optimization initiatives, pharmaceutical companies are oriented towards optimizing production processes and meeting regulatory requirements while still complying with high service levels, being internal factors the ones prevailing when making inventory management decisions. Furthermore, this paper investigates, through predictive modelling techniques, how various intrinsic and extrinsic factors influence the inventory configurations of the case study company. The study shows that inventory configurations are relatively unstable over time, especially in configurations that present high safety stock levels; and that production features and product characteristics are important explanatory factors behind high inventory levels. Regulatory requirements also play an important role in explaining the high strategic inventory levels that pharmaceutical companies hold

XML Schema Clustering with Semantic and Hierarchical Similarity Measures

With the growing popularity of XML as the data representation language, collections of the XML data are exploded in numbers. The methods are required to manage and discover the useful information from them for the improved document handling. We present a schema clustering process by organising the heterogeneous XML schemas into various groups. The methodology considers not only the linguistic and the context of the elements but also the hierarchical structural similarity. We support our findings with experiments and analysis

Knowledge Management and the Effectiveness of Innovation Outcomes: The Role of Cultural Barriers

In this paper we propose a conceptual model to test the moderating effect of cultural barriers on the link between knowledge strategies and innovation using healthcare organizations. In order to study the tie (knowledge-innovation) and the effects of the moderating variable (cultural barriers), the resource-based view is followed. It has been generally accepted that both explicit and tacit knowledge play a basic role in organizational innovation. However, there are few research works that study the relationship between knowledge management strategy and the effectiveness of the innovation process. On the other hand, the extant research on this relationship has yielded inconclusive results. Our paper revisits this research topic based on data of knowledge management strategy, Knowledge base, cultural barriers and innovation outcomes from a sample of Spanish hospitals

Dispositional Influences on Attributions Concerning Absenteeism

Because the degree to which absenteeism is within or beyond an employee\u27s control is a significant yet unresolved issue in the absence literature, it is important to understand the factors which influence employees\u27 attributions about the causes of absence events. As a result of recent research suggesting that personality variables are important influences on work attitudes and behaviors, the present study took a dispositional approach in investigating the predictors of employee absence attributions. Using data collected from three sources, between-subjects analyses suggested a number of dispositional influences on absence attributions. Within-subjects analyses suggested that the factors leading to external attributions vary widely across individuals

Dynamics of organizational culture: Individual beliefs vs. social conformity

The complex nature of organizational culture challenges our ability to infers its underlying dynamics from observational studies. Recent computational studies have adopted a distinct different view, where plausible mechanisms are proposed to describe a wide range of social phenomena, including the onset and evolution of organizational culture. In this spirit, this work introduces an empirically-grounded, agent-based model which relaxes a set of assumptions that describes past work - (a) omittance of an individual's strive for achieving cognitive coherence, (b) limited integration of important contextual factors - by utilizing networks of beliefs and incorporating social rank into the dynamics. As a result, we illustrate that: (i) an organization may appear to be increasingly coherent in terms of organizational culture, yet be composed of individuals with reduced levels of coherence, (ii) the components of social conformity - peer-pressure and social rank - are influential at different aggregation levels.Comment: 20 pages, 8 figure

Patterns of innovatin networking in Dutch small firms

Small firms may rely on a variety of network partners, and in various roles, to identify and exploit opportunities for innovation. This paper adds to the literature on innovation networking by developing a typology at the level of innovation objects, rather than at the firm or industry level. �