Filtering for nonlinear genetic regulatory networks with stochastic disturbances

In this paper, the filtering problem is investigated for nonlinear genetic regulatory networks with stochastic disturbances and time delays, where the nonlinear function describing the feedback regulation is assumed to satisfy the sector condition, the stochastic perturbation is in the form of a scalar Brownian motion, and the time delays exist in both the translation process and the feedback regulation process. The purpose of the addressed filtering problem is to estimate the true concentrations of the mRNA and protein. Specifically, we are interested in designing a linear filter such that, in the presence of time delays, stochastic disturbances as well as sector nonlinearities, the filtering dynamics of state estimation for the stochastic genetic regulatory network is exponentially mean square stable with a prescribed decay rate lower bound beta. By using the linear matrix inequality (LMI) technique, sufficient conditions are first derived for ensuring the desired filtering performance for the gene regulatory model, and the filter gain is then characterized in terms of the solution to an LMI, which can be easily solved by using standard software packages. A simulation example is exploited in order to illustrate the effectiveness of the proposed design procedures

μ-Dependent model reduction for uncertain discrete-time switched linear systems with average dwell time

In this article, the model reduction problem for a class of discrete-time polytopic uncertain switched linear systems with average dwell time switching is investigated. The stability criterion for general discrete-time switched systems is first explored, and a μ-dependent approach is then introduced for the considered systems to the model reduction solution. A reduced-order model is constructed and its corresponding existence conditions are derived via LMI formulation. The admissible switching signals and the desired reduced model matrices are accordingly obtained from such conditions such that the resulting model error system is robustly exponentially stable and has an exponential H∞ performance. A numerical example is presented to demonstrate the potential and effectiveness of the developed theoretical results

Robust Fault Detection of Switched Linear Systems with State Delays

This correspondence deals with the problem of robust fault detection for discrete-time switched systems with state delays under an arbitrary switching signal. The fault detection filter is used as the residual generator, in which the filter parameters are dependent on the system mode. Attention is focused on designing the robust fault detection filter such that, for unknown inputs, control inputs, and model uncertainties, the estimation error between the residuals and faults is minimized. The problem of robust fault detection is converted into an H infin-filtering problem. By a switched Lyapunov functional approach, a sufficient condition for the solvability of this problem is established in terms of linear matrix inequalities. A numerical example is provided to demonstrate the effectiveness of the proposed method

Stochastic model predictive control for constrained networked control systems with random time delay

In this paper the continuous time stochastic constrained optimal control problem is formulated for the class of networked control systems assuming that time delays follow a discrete-time, finite Markov chain . Polytopic overapproximations of the system's trajectories are employed to produce a polyhedral inner approximation of the non-convex constraint set resulting from imposing the constraints in continuous time. The problem is cast in a Markov jump linear systems (MJLS) framework and a stochastic MPC controller is calculated explicitly, oine, coupling dynamic programming with parametric piecewise quadratic (PWQ) optimization. The calculated control law leads to stochastic stability of the closed loop system, in the mean square sense and respects the state and input constraints in continuous time

Mathematical control of complex systems

Copyright © 2013 ZidongWang et al.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited