Particle Physics Instrumentation

This report summarizes a series of three lectures aimed at giving an overview of basic particle detection principles, the interaction of particles with matter, the application of these principles in modern detector systems, as well techniques to read out detector signals in high-rate experiments.Comment: 11 pages, contribution to the 1st Asia-Europe-Pacific School of High-Energy Physics, Fukuoka, Japan, 14 - 27 Oct 201

Development of the readout electronics for the high luminosity upgrade of the CMS outer strip tracker

The High-luminosity upgrade of the LHC will deliver the dramatic increase in luminosity required for precision measurements and to probe Beyond the Standard Model theories. At the same time, it will present unprecedented challenges in terms of pileup and radiation degradation. The CMS experiment is set for an extensive upgrade campaign, which includes the replacement of the current Tracker with another all-silicon detector with improved performance and reduced mass. One of the most ambitious aspects of the future Tracker will be the ability to identify high transverse momentum track candidates at every bunch crossing and with very low latency, in order to include tracking information at the L1 hardware trigger stage, a critical and effective step to achieve triggers with high purity and low threshold. This thesis presents the development and the testing of the CMS Binary Chip 2 (CBC2), a prototype Application Specific Integrated Circuit (ASIC) for the binary front-end readout of silicon strip detectors modules in the Outer Tracker, which also integrates the logic necessary to identify high transverse momentum candidates by correlating hits from two silicon strip detectors, separated by a few millimetres. The design exploits the relation between the transverse momentum and the curvature in the trajectory of charged particles subject to the large magnetic field of CMS. The logic which follows the analogue amplification and binary conversion rejects clusters wider than a programmable maximum number of adjacent strips, compensates for the geometrical offset in the alignment of the module, and correlates the hits between the two sensor layers. Data are stored in a memory buffer before being transferred to an additional buffer stage and being serially read-out upon receipt of a Level 1 trigger. The CBC2 has been subject to extensive testing since its production in January 2013: this work reports the results of electrical characterization, of the total ionizing dose irradiation tests, and the performance of a prototype module instrumented with CBC2 in realistic conditions in a beam test. The latter is the first experimental demonstration of the Pt-selection principle central to the future of CMS. Several total-ionizing-dose tests highlighted no functional issue, but observed significant excess static current for doses <1 Mrad. The source of the excess was traced to static leakage current in the memory pipeline, and is believed to be a consequence of the high instantaneous dose delivered by the x-ray setup. Nevertheless, a new SRAM layout aimed at removing the leakage path was proposed for the CBC3. The results of single event upset testing of the chip are also reported, two of the three distinct memory circuits used in the chip were proven to meet the expected robustness, while the third will be replaced in the next iteration of the chip. Finally, the next version of the ASIC is presented, highlighting the additional features of the final prototype, such as half-strip resolution, additional trigger logic functionality, longer trigger latency and higher rate, and fully synchronous stub readout.Open Acces

A distributed analysis and monitoring framework for the compact Muon solenoid experiment and a pedestrian simulation

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The design of a parallel and distributed computing system is a very complicated task. It requires a detailed understanding of the design issues and of the theoretical and practical aspects of their solutions. Firstly, this thesis discusses in detail the major concepts and components required to make parallel and distributed computing a reality. A multithreaded and distributed framework capable of analysing the simulation data produced by a pedestrian simulation software was developed. Secondly, this thesis discusses the origins and fundamentals of Grid computing and the motivations for its use in High Energy Physics. Access to the data produced by the Large Hadron Collider (LHC) has to be provided for more than five thousand scientists all over the world. Users who run analysis jobs on the Grid do not necessarily have expertise in Grid computing. Simple, userfriendly and reliable monitoring of the analysis jobs is one of the key components of the operations of the distributed analysis; reliable monitoring is one of the crucial components of the Worldwide LHC Computing Grid for providing the functionality and performance that is required by the LHC experiments. The CMS Dashboard Task Monitoring and the CMS Dashboard Job Summary monitoring applications were developed to serve the needs of the CMS community

Belle II Technical Design Report

The Belle detector at the KEKB electron-positron collider has collected almost 1 billion Y(4S) events in its decade of operation. Super-KEKB, an upgrade of KEKB is under construction, to increase the luminosity by two orders of magnitude during a three-year shutdown, with an ultimate goal of 8E35 /cm^2 /s luminosity. To exploit the increased luminosity, an upgrade of the Belle detector has been proposed. A new international collaboration Belle-II, is being formed. The Technical Design Report presents physics motivation, basic methods of the accelerator upgrade, as well as key improvements of the detector.Comment: Edited by: Z. Dole\v{z}al and S. Un

Physicochemical aspects of pharmaceutically‐relevant polymers and nanoparticles in solution

Pharmapolymers, colloids, and self-assembled systems for biomedical purposes have gained significant importance in the last decades. Besides innovative synthesis routes and formulation techniques, the characterization of these multicomponent systems is of great importance to obtain an insight into their physicochemical properties. As presented in this thesis, analytical ultracentrifugation with multi-detection represents a characterization tool with great potential for analyzing macromolecules and polymer-based nanocarriers in solution. Besides analytical ultracentrifugation, asymmetrical flow field‐flow fractionation coupled to a multi‐angle laser light scattering detector can be utilized to determine essential properties such as particle sizes or molar masses of macromolecules. In this thesis, methods of analytical ultracentrifugation were developed to analyze polymeric nanocarriers. The results were compared to well-established orthogonal techniques such as asymmetrical flow field‐flow fractionation coupled to a light scattering detector and standard dynamic light scattering. Thereby, different polymeric multicomponent systems, including nanoparticles, polyplexes, micelles, and bioconjugates were studied. These investigations delivered information such as the colocalization of multiple components, i. e., drug, as well as degradation and drug release studies under various conditions. In particular, studies in human serum and at body temperature are of great importance before in vivo experiments are performed. The presented results will allow to overcome current analytical challenges in the characterization of such multicomponent systems for life science applications and boost the synthetic / formulation improvements due to a deep physicochemical understanding of the systems

Development of limb volume measuring system

The mechanisms underlying the reductions in orthostatic tolerance associated with weightlessness are not well established. Contradictory results from measurements of leg volume changes suggest that altered venomotor tone and reduced blood flow may not be the only contributors to orthostatic intolerance. It is felt that a more accurate limb volume system which is insensitive to environmental factors will aid in better quantification of the hemodynamics of the leg. Of the varous limb volume techniques presently available, the ultrasonic limb volume system has proven to be the best choice. The system as described herein is free from environmental effects, safe, simple to operate and causes negligible radio frequency interference problems. The segmental ultrasonic ultrasonic plethysmograph is expected to provide a better measurement of limb volume change since it is based on cross-sectional area measurements