Practopoiesis: Or how life fosters a mind

The mind is a biological phenomenon. Thus, biological principles of organization should also be the principles underlying mental operations. Practopoiesis states that the key for achieving intelligence through adaptation is an arrangement in which mechanisms laying a lower level of organization, by their operations and interaction with the environment, enable creation of mechanisms lying at a higher level of organization. When such an organizational advance of a system occurs, it is called a traverse. A case of traverse is when plasticity mechanisms (at a lower level of organization), by their operations, create a neural network anatomy (at a higher level of organization). Another case is the actual production of behavior by that network, whereby the mechanisms of neuronal activity operate to create motor actions. Practopoietic theory explains why the adaptability of a system increases with each increase in the number of traverses. With a larger number of traverses, a system can be relatively small and yet, produce a higher degree of adaptive/intelligent behavior than a system with a lower number of traverses. The present analyses indicate that the two well-known traverses-neural plasticity and neural activity-are not sufficient to explain human mental capabilities. At least one additional traverse is needed, which is named anapoiesis for its contribution in reconstructing knowledge e.g., from long-term memory into working memory. The conclusions bear implications for brain theory, the mind-body explanatory gap, and developments of artificial intelligence technologies.Comment: Revised version in response to reviewer comment

Mission impossible: operations management in complex, extreme, and hostile environments

This PhD thesis seeks to advance knowledge on operations management (OM) challenges and strategies for crisis management in general and humanitarian relief in particular. Although knotty crisis situations are increasing in frequency, duration, and impact, their implications for OM remain ill-understood. I use the humanitarian context as a research setting because its features inherently render it challenging. Through comprehensive empirical studies, I explore the implications of complexity, extremity, and hostility for the operations of international humanitarian organisations (IHOs). The most crucial insights concern how contextual features impact IHOs’ decision space and outcomes. In studying complex emergencies as an exemplar phenomenon that induces complexity because of its politically charged nature, I find that inherent tensions between host government and IHOs interests lead to logistical inefficiencies for IHOs. Host government regulation and enforcement capabilities determine their nature and severity. My exploration of extremity caused by overlapping disasters leads to the curious finding that humanitarian supply networks exhibit resilience to overcome, and benefit from, unprecedented crises. Nonetheless, resilience capabilities and considerations become unsuitable as crises become long-drawn out. To explore the implications of hostility, I study operations in armed conflicts. Results show that when strategizing, the main trade-offs are cross-cutting between Humanitarian Action (HA) principles and OM performance objectives. Interestingly, the same IHO strategy leads to different results across conflicts. Overall, this thesis demonstrates that alternatives to conventional OM strategy and practices are needed in knotty contexts. The findings will be of interest to researchers and practitioners in OM, HA, and crisis management

Altered developmental programming of the mouse mammary gland in female offspring following perinatal dietary exposures : a systems-biology perspective.

Mishaps in prenatal development can influence mammary gland development and, ultimately, affect susceptibility to factors that cause breast cancer. This research was based on the underlying hypothesis that maternal dietary composition during pregnancy can alter developmental (fetal) programming of the mammary gland. We used a computational systems-biology approach and Bayesian-based stochastic search variable selection algorithm (SSVS) to identify differentially expressed genes and biological themes and pathways. Postnatal growth trajectories and gene expression in the mammary gland at 10-weeks of age in female mice were investigated following different maternal diet exposures during prenatal-lactational-early-juvenile development. This correlated a decrease in expression of energy pathways with a reciprocal increase in cytokine and inflammatory-signaling pathways. These findings suggest maternal dietary fat exposure significantly influences postnatal growth trajectories, metabolic programming, and signaling networks in the mammary gland of female offspring. In addition, the adipocytokine pathway may be a sensitive trigger to dietary changes and may influence or enhance activation of an immune response, a key event in cancer development

Apperceptive patterning: Artefaction, extensional beliefs and cognitive scaffolding

In “Psychopower and Ordinary Madness” my ambition, as it relates to Bernard Stiegler’s recent literature, was twofold: 1) critiquing Stiegler’s work on exosomatization and artefactual posthumanism—or, more specifically, nonhumanism—to problematize approaches to media archaeology that rely upon technical exteriorization; 2) challenging how Stiegler engages with Giuseppe Longo and Francis Bailly’s conception of negative entropy. These efforts were directed by a prevalent techno-cultural qualifier: the rise of Synthetic Intelligence (including neural nets, deep learning, predictive processing and Bayesian models of cognition). This paper continues this project but first directs a critical analytic lens at the Derridean practice of the ontologization of grammatization from which Stiegler emerges while also distinguishing how metalanguages operate in relation to object-oriented environmental interaction by way of inferentialism. Stalking continental (Kapp, Simondon, Leroi-Gourhan, etc.) and analytic traditions (e.g., Carnap, Chalmers, Clark, Sutton, Novaes, etc.), we move from artefacts to AI and Predictive Processing so as to link theories related to technicity with philosophy of mind. Simultaneously drawing forth Robert Brandom’s conceptualization of the roles that commitments play in retrospectively reconstructing the social experiences that lead to our endorsement(s) of norms, we compliment this account with Reza Negarestani’s deprivatized account of intelligence while analyzing the equipollent role between language and media (both digital and analog)

Unlocking digital competition, Report of the Digital Competition Expert Panel

This is the final report of the Digital Competition Expert Panel. Appointed by the Chancellor in 2018, and chaired by former Chief Economist to President Obama, Professor Jason Furman, the Panel makes recommendations for changes to the UK’s competition framework that are needed to face the economic challenges posed by digital markets, in the UK and internationally. Their report recommends updating the rules governing merger and antitrust enforcement, as well as proposing a bold set of pro-competition measures to open up digital markets

Activist Social Entrepreneurship: A Case Study of the Green Campus Co-operative

The globalization of the garment industry has encouraged transnational companies to further externalize their cost of production on workers and the environment around the world. Producing countries are engaging in what many scholars refer to as a “race to the bottom” regarding global wages and labor standards as these countries compete to attract foreign investment. There have been many attempts to push back against the egregious effects of this process through anti- sweatshop campaigns, laws, codes of conduct, union activism, and most recently, social enterprise. While these actors have traction in some ways we have yet to see significant changes in the behaviour of transnational corporations. This action- research case study introduces the concept of the activist social enterprise that not only engages in commercial activity but also advances a social and/or environmental mission through institutional entrepreneurship practices, in this specific case fair trade. Using institutional entrepreneurship theory, social capital theory and cognitive frames theory this case study attempts to create a normative framework to understand how social enterprises can begin to pave the way for systemic change in the garment industry by: 1. Fighting to capture and influence institutional norms and regulations of business behaviour. 2. Training managers to embrace the navigation of trade-offs between economic, social and environmental progress. 3. Leverage social capital to develop a radical mainstreaming distribution strategy when competing with traditional corporations

Business model innovation for sustainable development: green technologies and BOP (Bottom of Pyramid) in emerging countries: South Africa and India

Doctoral research dissertation in the fulfilment of the requirements for the degree Doctor of Philosophy in Marketing at the Faculty of Commerce, Law and Management, University of the Witwatersrand, Johannesburg, South Africa, 2016Globally, a vision exists of an economy which produces social, environmental and economic benefits, viz-a-viz three pillars of sustainable development, for all the individuals, communities and society at large. It also focuses on the development of the sustainable use of natural resources, to achieve a greater enviable society, therefore giving rise to the green economy (Bigg 2011). To make businesses sustainable, companies are increasingly focusing on green innovation, sustainable business solutions and re-inventing their business models, and expanding to untapped markets such as the bottom of the pyramid (BOP), consisting of more than four billion potential consumers (Farinelli, Bottini, Akkoyunlu & Aerni, 2011). Most research shows growth opportunities of green products in the bottom of pyramid (Olsen & Boxenbaum, 2009), and has increasingly created deliberations all over the world. Also, companies from both developed and developing countries are becoming increasingly interested in BOP. To successfully target the BOP with ‘green’ technologies, companies focus their business models on innovation, sustainability and economic profit, instead of gross margins (Prahalad & Hart, 2008). Very limited research evidence is present that links all these concepts together. And therefore, created an interest to examine how integration of green technology bring changes in business model innovation (BMI) for sustainability at BOP markets. The linkage between concepts - BMI, BOP and green technology, to bring sustainable development, has not been sufficiently explored, and especially with focus on emerging economies like South Africa and India. Therefore, the present research has three fold purposes. Firstly, to analyse and understand factors affecting the existing business models of various companies with green technologies targeting BOP markets for sustainable development. Secondly, the research brings an identification and understanding of number of key factors related to BMI, BOP markets and green technologies for sustainable development, and proposes a conceptual framework based on a series of underpinning relationships among these factors. Thirdly, it testifies the conceptualized theoretical framework on green business model innovation for sustainable development for BOP markets, among large companies. The primary objective of research study is to design a right green business model innovation across companies with green technologies for BOP markets. The secondary objective is to identify and compare the differences and similarities of green business model innovation for BOP markets of both South Africa and India. The present research undertakes a sequential exploratory mixed method approach, and is carried out in three phases: Phase 1: Exploration and study of business model innovation of identified industries/sectors with green technologies, targeting BOP segment for sustainable development, using qualitative research methods to formulate multiple cases. Phase 2: Identification of underpinning factors related to BMI, sustainable development and BOP consumers for green technologies; using qualitative methods and content analysis of results from phase 1, leading to design and development of theoretical framework of green business model innovation for South Africa and India. Phase 3: Testing of conceptualized framework of green business model innovation for sustainable development, using quantitative research methods. The present research tests underpinning factors of emerging green business model innovation for sustainable development, resulting from the qualitative phase, and is used to expand and generalize qualitative findings by using quantitative methods. The findings resulted in linking three theoretical emerging topics in the literature: business model innovation (BMI), green technology for sustainability and BOP. Four cases are developed through 33 face-to-face in-depth interviews with company top executives, using multiple case study approach. Each case comprised of sustainable business model innovation, representing comparison between South Africa and India, across four industries, namely, Energy, Banking, FMCG/Durable sectors and Cloud Computing. Qualitative content analysis and findings resulted in formation of themes and sub-themes and proposed prepositions, depicting the relationship between BMI, BOP, and green technology for sustainability. These prepositions aided in development of conceptual framework and proposed nine hypotheses. The conceptual model is quantitatively surveyed on 206 employees of large companies with focus on BOP markets. The quantitative findings supported all nine hypotheses. Therefore, indicating that integration of green technology is associated with performance of green product/service innovation and green process innovation in a company. Likewise, business model innovation variables; customer interface, infrastructure management and financial aspects, positively impacts sustainability of business model. The contribution of this thesis is in the development of green business model innovation for sustainable development, with focus on BOP markets. This adds to the contextual knowledge and empirical literature on business model innovation, green technologies and BOP markets. Theoretically, it brings better understanding of these concepts, and provides a basis of further research highlighting the importance of innovation while taking account of green economy and BOP. The findings provide marketing practitioners with better understanding of strategies that can be employed to innovate and change their own business models to incorporate green and sustainable initiative for BOP markets.XL201