Practopoiesis: Or how life fosters a mind

The mind is a biological phenomenon. Thus, biological principles of organization should also be the principles underlying mental operations. Practopoiesis states that the key for achieving intelligence through adaptation is an arrangement in which mechanisms laying a lower level of organization, by their operations and interaction with the environment, enable creation of mechanisms lying at a higher level of organization. When such an organizational advance of a system occurs, it is called a traverse. A case of traverse is when plasticity mechanisms (at a lower level of organization), by their operations, create a neural network anatomy (at a higher level of organization). Another case is the actual production of behavior by that network, whereby the mechanisms of neuronal activity operate to create motor actions. Practopoietic theory explains why the adaptability of a system increases with each increase in the number of traverses. With a larger number of traverses, a system can be relatively small and yet, produce a higher degree of adaptive/intelligent behavior than a system with a lower number of traverses. The present analyses indicate that the two well-known traverses-neural plasticity and neural activity-are not sufficient to explain human mental capabilities. At least one additional traverse is needed, which is named anapoiesis for its contribution in reconstructing knowledge e.g., from long-term memory into working memory. The conclusions bear implications for brain theory, the mind-body explanatory gap, and developments of artificial intelligence technologies.Comment: Revised version in response to reviewer comment

Conservation and crime convergence? Situating the 2018 London Illegal Wildlife Trade Conference

The 2018 London Illegal Wildlife Trade (IWT) Conference was the fourth and biggest meeting on IWT convened at the initiative of the UK Government. Using a collaborative event ethnography, we examine the Conference as a site where key actors defined the problem of IWT as one of serious crime that needs to be addressed as such. We ask (a) how was IWT framed as serious crime, (b) how was this framing mobilized to promote particular policy responses, and (c) how did the framing and suggested responses reflect the privileging of elite voices? Answering these questions demonstrates the expanding ways in which thinking related to crime and policing are an increasingly forceful dynamic shaping conservation-related policy at the global level. We argue that the conservation-crime convergence on display at the 2018 London IWT Conference is characteristic of a conservation policy landscape that increasingly promotes and privileges responses to IWT that are based on legal and judicial reform, criminal investigations, intelligence gathering, and law enforcement technologies. Marginalized are those voices that seek to address the underlying drivers of IWT by promoting solutions rooted in sustainable livelihoods in source countries and global demand reduction. We suggest that political ecology of conservation and environmental crime would benefit from greater engagement with critical criminology, a discipline that critically interrogates the uneven power dynamics that shape ideas of crime, criminality, how they are politicized, and how they frame policy decisions. This would add further conceptual rigor to political ecological work that deconstructs conservation and environmental crime

Some Ontological Principles for Designing Upper Level Lexical Resources

The purpose of this paper is to explore some semantic problems related to the use of linguistic ontologies in information systems, and to suggest some organizing principles aimed to solve such problems. The taxonomic structure of current ontologies is unfortunately quite complicated and hard to understand, especially for what concerns the upper levels. I will focus here on the problem of ISA overloading, which I believe is the main responsible of these difficulties. To this purpose, I will carefully analyze the ontological nature of the categories used in current upper-level structures, considering the necessity of splitting them according to more subtle distinctions or the opportunity of excluding them because of their limited organizational role.Comment: 8 pages - gzipped postscript file - A4 forma

Distributed Hypothesis Testing, Attention Shifts and Transmitter Dynatmics During the Self-Organization of Brain Recognition Codes

BP (89-A-1204); Defense Advanced Research Projects Agency (90-0083); National Science Foundation (IRI-90-00530); Air Force Office of Scientific Research (90-0175, 90-0128); Army Research Office (DAAL-03-88-K0088

A multi-INT semantic reasoning framework for intelligence analysis support

Lockheed Martin Corp. has funded research to generate a framework and methodology for developing semantic reasoning applications to support the discipline oflntelligence Analysis. This chapter outlines that framework, discusses how it may be used to advance the information sharing and integrated analytic needs of the Intelligence Community, and suggests a system I software architecture for such applications

Multilevel analysis of nuclear dynamics in lamin perturbed fibroblasts

The nuclear lamina provides structural support to the nucleus and has a central role in defining nuclear organization. Defects in its filamentous constituents, the lamins, lead to a class of diseases collectively referred to as laminopathies. On the cellular level, lamin mutations affect the physical integrity of nuclei and nucleo-cytoskeletal interactions, resulting in increased susceptibility to mechanical stress and altered gene expression [1]. Most studies regarding the mechanical properties of the nucleus in laminopathic conditions are based on the induction of extracellular stress, such as strain or compression, and focus on nuclear integrity and/or nucleo-cytoskeletal interaction [2]. Far less is known about the role of nuclear organization and mobility under basal steady-state conditions. In this study, we quantitatively compared nuclear organization, nuclear deformation and chromatin mobility of fibroblasts from a Hutchinson-Gilford progeria patient with cells from a lamin A/C-deficient patient and wild-type dermal fibroblasts. To this end, we created a toolbox in imageJ for automatically analyzing both nuclear as well as subnuclear dynamics in living cells. Simultaneously, we developed a workflow for comparing cellular morphology and subcellular protein distribution in a high content fashion. We found that the absence of functional lamin A/C leads to increased nuclear plasticity on the hour and minute time scale but also to increased intranuclear mobility down to the seconds time scale. In contrast, progeria cells showed overall reduced nuclear dynamics. In addition, high content analysis revealed marked morphological and topological differences between different culture passages within a cell type and between different pathological variants of culture-age matched laminopathic cell types

Cloning and characterisation of multiple ferritin isoforms in the Atlantic salmon (Salmo salar)

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