1,089 research outputs found
Prior Guided Deep Difference Meta-Learner for Fast Adaptation to Stylized Segmentation
When a pre-trained general auto-segmentation model is deployed at a new
institution, a support framework in the proposed Prior-guided DDL network will
learn the systematic difference between the model predictions and the final
contours revised and approved by clinicians for an initial group of patients.
The learned style feature differences are concatenated with the new patients
(query) features and then decoded to get the style-adapted segmentations. The
model is independent of practice styles and anatomical structures. It
meta-learns with simulated style differences and does not need to be exposed to
any real clinical stylized structures during training. Once trained on the
simulated data, it can be deployed for clinical use to adapt to new practice
styles and new anatomical structures without further training.
To show the proof of concept, we tested the Prior-guided DDL network on six
different practice style variations for three different anatomical structures.
Pre-trained segmentation models were adapted from post-operative clinical
target volume (CTV) segmentation to segment CTVstyle1, CTVstyle2, and
CTVstyle3, from parotid gland segmentation to segment Parotidsuperficial, and
from rectum segmentation to segment Rectumsuperior and Rectumposterior. The
mode performance was quantified with Dice Similarity Coefficient (DSC). With
adaptation based on only the first three patients, the average DSCs were
improved from 78.6, 71.9, 63.0, 52.2, 46.3 and 69.6 to 84.4, 77.8, 73.0, 77.8,
70.5, 68.1, for CTVstyle1, CTVstyle2, and CTVstyle3, Parotidsuperficial,
Rectumsuperior, and Rectumposterior, respectively, showing the great potential
of the Priorguided DDL network for a fast and effortless adaptation to new
practice style
Artificial Intelligence in Radiation Therapy
Artificial intelligence (AI) has great potential to transform the clinical workflow of radiotherapy. Since the introduction of deep neural networks, many AI-based methods have been proposed to address challenges in different aspects of radiotherapy. Commercial vendors have started to release AI-based tools that can be readily integrated to the established clinical workflow. To show the recent progress in AI-aided radiotherapy, we have reviewed AI-based studies in five major aspects of radiotherapy including image reconstruction, image registration, image segmentation, image synthesis, and automatic treatment planning. In each section, we summarized and categorized the recently published methods, followed by a discussion of the challenges, concerns, and future development. Given the rapid development of AI-aided radiotherapy, the efficiency and effectiveness of radiotherapy in the future could be substantially improved through intelligent automation of various aspects of radiotherapy
Auto-Segmentation of Target Volume and Organs-at-risks for Radiotherapy in Breast Cancer patients
๋ชฉ์ : ์ ๋ฐฉ์ ๋ฐฉ์ฌ์ ์น๋ฃ์์ ์น๋ฃ ์ฒด์ ์ ๋ํ ์ ํํ ํ๊ฒ ๊ทธ๋ฆฌ๊ธฐ๋ ์ค์ํ๋ค. ํ์ง๋ง ๋ฐฉ์ฌ์ ์น๋ฃ ๊ณํ ๊ณผ์ ์ ํ๊ฒ ๊ทธ๋ฆฌ๊ธฐ๋ ์๋ฃ์ง์ ๋ถ๋ด์ ์ฃผ๊ณ ์์ผ๋ฉฐ, ์๋ฃ์ง ๊ฐ์ ํธ์ฐจ๋ ์กด์ฌํ๊ณ ์๋ค. ๋ณธ ์ฐ๊ตฌ์์๋ Deep learning-based auto-segmentation (DLBAS)์ ์ฑ๋ฅ์ atlas-based segmentation solutions (ABAS)์ ๋น๊ตํ๊ณ , ์์ ์์ฌ์ ๊ด์ ์์ ์ ์ฉ์ฑ์ ํ๊ฐํ๊ณ , ์ต์ข
์ ์ผ๋ก ์ธ๋ถ ํ๋น๋ ์กฐ์ฌ๋ฅผ ํตํ์ฌ ์ ๋ฐฉ์ ๋ฐฉ์ฌ์ ์น๋ฃ์์ ์๋ ๊ตฌํํ์ ๊ฐ๋ฅ์ฑ์ ๊ท๋ช
ํ๊ณ ์ ํ๋ค. ๋์ ๋ฐ ๋ฐฉ๋ฒ: ์ ๋ฐฉ์ ๋ฐฉ์ฌ์ ์น๋ฃ ์ฒด์ ๊ณผ ์ ์์ฅ๊ธฐ๋ค์ ๋ํ์ฌ ํ ๋ช
์ ์ฐ๊ตฌ์ง์ ์ํ์ฌ ๊ตฌํํ ์ ๋ณด๋ฅผ ์์ฑํ์๋ค. Convolutional neural network ์๊ณ ๋ฆฌ์ฆ์ ์ด์ฉํ์ฌ auto-contours๋ฅผ ์์ฑํ์๊ณ , Dice similarity coefficient (DSC) and 95% Hausdorff distance (HD)๋ฅผ ์ด์ฉํ์ฌ ABAS์ ๋น๊ตํ์๋ค. DLBAS์ ์ํด ์์ฑ๋ auto-contours์ ์ง์ ์ธ ํ๊ฐ๋ฅผ ์กฐ์ฌํ์๊ณ , manual contours์ ๋ฐฉ์ฌ์ ์น๋ฃ ์ ๋-์ฒด์ ํ์คํ ๊ทธ๋จ์ ๋น๊ตํ์ฌ ์ฃผ์ ์ ๋ํ๊ฐ๋ถ์์ ์ํํ์๋ค. ๋ง์ง๋ง์ผ๋ก 2๊ฐ ๊ธฐ๊ด์ 11๋ช
์ ์ ๋ฌธ๊ฐ์๊ฒ manual contour๋ฅผ ๊ทธ๋ฆด ๊ฒ์ ์์ฒญํ์ฌ ๋ฐ์ดํฐ๋ฅผ ์์งํ์๋ค. ์ธ๋ถ ์์ํ๋ฅผ ํตํด ๊ฐ์ฅ ์ต์ ์ ์น๋ฃ ์ฒด์ ์ ์ ์ ํ์๊ณ , ๋๋จธ์ง 10๋ช
์ contour์ DLBAS์ ์ํด ์์ฑ๋ auto-contour์ ์ฑ๋ฅ์ ๋น๊ตํ์ฌ ์์ ํ๊ฐ๋ฅผ ์ํํ์๋ค. ๊ฒฐ๊ณผ: ์ ์๋ DLBAS ๋ชจ๋ธ์ ๋๋ถ๋ถ์ ์ฒด์ (ํนํ, ์น๋ฃ ์ฒด์ ๊ณผ ์ฌ์ฅ ์ธ๋ถ๊ตฌ์กฐ)์์ ABAS๋ณด๋ค ๋ ์ผ๊ด๋ ๊ฒฐ๊ณผ์ ๋์ DSC์ ๋ฎ์ HD ๊ฒฐ๊ณผ ๊ฐ์ ๋ณด์๋ค. ABAS๋ ์ฐ์กฐ์ง์ ์ ์์ฅ๊ธฐ์ ์กฐ์์ ๋ฅผ ์ฐ์ง ์์ ์๋ก์ด ๋ฐ์ดํฐ ์
์์ DLBAS์ ๋นํด, ์ ํ์ ์ธ ์ฑ๋ฅ์ ๋ณด์๋ค. ์ง์ ํ๊ฐ๋ฅผ ์ํ ์ค๋ฌธ์กฐ์ฌ๊ฐ ์ํ๋์๊ณ , ์ค์์ 8์ ์ผ๋ก manual contour์ auto-contour ์ฌ์ด์ ์ฐจ์ด๊ฐ ํฌ์ง ์๋ค๊ณ ๋๋ตํ์์ผ๋ฉฐ, ์์์์ ๋์์ด ๋ ๊ฒ์ผ๋ก ๋ต๋ณํ์๋ค. ๋ํ ์ ๋ํ๊ฐ ๋ถ์ ๊ฒฐ๊ณผ์์ ์ฐจ์ด๋ ๋ฏธ๋ฏธํ์๋ค. ์ธ๋ถ ๊ฒ์ฆ ๊ฒฐ๊ณผ, 9๊ฐ์ ์ ์์ฅ๊ธฐ๋ฅผ ๊ทธ๋ฆฌ๋๋ฐ ํ๊ท 37๋ถ์ด ๊ฑธ๋ ธ๊ณ , DLBAS๋ 6๋ถ์ด ๊ฑธ๋ ธ๋ค. Auto-contour๋ ์ ์ฒด 12๊ฐ ์ค 1์ manual contour์ ๋น๊ตํ์์ ๋ ๊ฐ์ฅ DSC์ ์ฐจ์ด๊ฐ ์ ์์ผ๋ฉฐ, HSD์ 2๋ฒ์งธ๋ก ์ฐจ์ด๊ฐ ์ ์๋ค. ์ ์์ฅ๊ธฐ์์ ๊ฐ์ฅ ํธ์ฐจ๊ฐ ๋์๋ ๋ถ์๋ ์ ๋ฐฉ์ด์๋ค. ๊ฒฐ๋ก : ์ ๋ฐฉ ๋ฐฉ์ฌ์ ์น๋ฃ ๊ณํ์์ DLBAS์ ์คํ๊ฐ๋ฅ์ฑ์ ์ด๋ฒ ์ฐ๊ตฌ์์ ๋ค๊ฐ๋๋ก ๊ฒ์ฆ๋์๋ค. ์๋ฃ์ง์ ์ต์ข
์์ ๊ณผ์ ์ ํ์์ ์ด์ง๋ง, ์์ผ๋ก DLBAS๋ ๋ฐฉ์ฌ์ ์น๋ฃ๋ฅผ ๋์ธ ์ ์๋ ํ๋ฅญํ ๊ฐ๋ฅ์ฑ์ ๋ณด์ฌ์ฃผ์๋ค.open๋ฐ
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