A review on automatic mammographic density and parenchymal segmentation

Breast cancer is the most frequently diagnosed cancer in women. However, the exact cause(s) of breast cancer still remains unknown. Early detection, precise identification of women at risk, and application of appropriate disease prevention measures are by far the most effective way to tackle breast cancer. There are more than 70 common genetic susceptibility factors included in the current non-image-based risk prediction models (e.g., the Gail and the Tyrer-Cuzick models). Image-based risk factors, such as mammographic densities and parenchymal patterns, have been established as biomarkers but have not been fully incorporated in the risk prediction models used for risk stratification in screening and/or measuring responsiveness to preventive approaches. Within computer aided mammography, automatic mammographic tissue segmentation methods have been developed for estimation of breast tissue composition to facilitate mammographic risk assessment. This paper presents a comprehensive review of automatic mammographic tissue segmentation methodologies developed over the past two decades and the evidence for risk assessment/density classification using segmentation. The aim of this review is to analyse how engineering advances have progressed and the impact automatic mammographic tissue segmentation has in a clinical environment, as well as to understand the current research gaps with respect to the incorporation of image-based risk factors in non-image-based risk prediction models

Mammography

In this volume, the topics are constructed from a variety of contents: the bases of mammography systems, optimization of screening mammography with reference to evidence-based research, new technologies of image acquisition and its surrounding systems, and case reports with reference to up-to-date multimodality images of breast cancer. Mammography has been lagged in the transition to digital imaging systems because of the necessity of high resolution for diagnosis. However, in the past ten years, technical improvement has resolved the difficulties and boosted new diagnostic systems. We hope that the reader will learn the essentials of mammography and will be forward-looking for the new technologies. We want to express our sincere gratitude and appreciation?to all the co-authors who have contributed their work to this volume

Image Analysis Applications of the Maximum Mean Discrepancy Distance Measure

The need to quantify distance between two groups of objects is prevalent throughout the signal processing world. The difference of group means computed using the Euclidean, or L2 distance, is one of the predominant distance measures used to compare feature vectors and groups of vectors, but many problems arise with it when high data dimensionality is present. Maximum mean discrepancy (MMD) is a recent unsupervised kernel-based pattern recognition method which may improve differentiation between two distinct populations over many commonly used methods such as the difference of means, when paired with the proper feature representations and kernels. MMD-based distance computation combines many powerful concepts from the machine learning literature, such as data distribution-leveraging similarity measures and kernel methods for machine learning. Due to this heritage, we posit that dissimilarity-based classification and changepoint detection using MMD can lead to enhanced separation between different populations. To test this hypothesis, we conduct studies comparing MMD and the difference of means in two subareas of image analysis and understanding: first, to detect scene changes in video in an unsupervised manner, and secondly, in the biomedical imaging field, using clinical ultrasound to assess tumor response to treatment. We leverage effective computer vision data descriptors, such as the bag-of-visual-words and sparse combinations of SIFT descriptors, and choose from an assessment of several similarity kernels (e.g. Histogram Intersection, Radial Basis Function) in order to engineer useful systems using MMD. Promising improvements over the difference of means, measured primarily using precision/recall for scene change detection, and k-nearest neighbour classification accuracy for tumor response assessment, are obtained in both applications.1 yea