9,690 research outputs found
Assessment of algorithms for mitosis detection in breast cancer histopathology images
The proliferative activity of breast tumors, which is routinely estimated by counting of mitotic figures in hematoxylin and eosin stained histology sections, is considered to be one of the most important prognostic markers. However, mitosis counting is laborious, subjective and may suffer from low inter-observer agreement. With the wider acceptance of whole slide images in pathology labs, automatic image analysis has been proposed as a potential solution for these issues.
In this paper, the results from the Assessment of Mitosis Detection Algorithms 2013 (AMIDA13) challenge are described. The challenge was based on a data set consisting of 12 training and 11 testing subjects, with more than one thousand annotated mitotic figures by multiple observers. Short descriptions and results from the evaluation of eleven methods are presented. The top performing method has an error rate that is comparable to the inter-observer agreement among pathologists
PathologyGAN: Learning deep representations of cancer tissue
We apply Generative Adversarial Networks (GANs) to the domain of digital
pathology. Current machine learning research for digital pathology focuses on
diagnosis, but we suggest a different approach and advocate that generative
models could drive forward the understanding of morphological characteristics
of cancer tissue. In this paper, we develop a framework which allows GANs to
capture key tissue features and uses these characteristics to give structure to
its latent space. To this end, we trained our model on 249K H&E breast cancer
tissue images, extracted from 576 TMA images of patients from the Netherlands
Cancer Institute (NKI) and Vancouver General Hospital (VGH) cohorts. We show
that our model generates high quality images, with a Frechet Inception Distance
(FID) of 16.65. We further assess the quality of the images with cancer tissue
characteristics (e.g. count of cancer, lymphocytes, or stromal cells), using
quantitative information to calculate the FID and showing consistent
performance of 9.86. Additionally, the latent space of our model shows an
interpretable structure and allows semantic vector operations that translate
into tissue feature transformations. Furthermore, ratings from two expert
pathologists found no significant difference between our generated tissue
images from real ones. The code, generated images, and pretrained model are
available at https://github.com/AdalbertoCq/Pathology-GANComment: MIDL 2020 final versio
Machine learning methods for histopathological image analysis
Abundant accumulation of digital histopathological images has led to the
increased demand for their analysis, such as computer-aided diagnosis using
machine learning techniques. However, digital pathological images and related
tasks have some issues to be considered. In this mini-review, we introduce the
application of digital pathological image analysis using machine learning
algorithms, address some problems specific to such analysis, and propose
possible solutions.Comment: 23 pages, 4 figure
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