6,360 research outputs found
Evolutionary Computation and QSAR Research
[Abstract] The successful high throughput screening of molecule libraries for a specific biological property is one of the main improvements in drug discovery. The virtual molecular filtering and screening relies greatly on quantitative structure-activity relationship (QSAR) analysis, a mathematical model that correlates the activity of a molecule with molecular descriptors. QSAR models have the potential to reduce the costly failure of drug candidates in advanced (clinical) stages by filtering combinatorial libraries, eliminating candidates with a predicted toxic effect and poor pharmacokinetic profiles, and reducing the number of experiments. To obtain a predictive and reliable QSAR model, scientists use methods from various fields such as molecular modeling, pattern recognition, machine learning or artificial intelligence. QSAR modeling relies on three main steps: molecular structure codification into molecular descriptors, selection of relevant variables in the context of the analyzed activity, and search of the optimal mathematical model that correlates the molecular descriptors with a specific activity. Since a variety of techniques from statistics and artificial intelligence can aid variable selection and model building steps, this review focuses on the evolutionary computation methods supporting these tasks. Thus, this review explains the basic of the genetic algorithms and genetic programming as evolutionary computation approaches, the selection methods for high-dimensional data in QSAR, the methods to build QSAR models, the current evolutionary feature selection methods and applications in QSAR and the future trend on the joint or multi-task feature selection methods.Instituto de Salud Carlos III, PIO52048Instituto de Salud Carlos III, RD07/0067/0005Ministerio de Industria, Comercio y Turismo; TSI-020110-2009-53)Galicia. ConsellerĂa de EconomĂa e Industria; 10SIN105004P
AI Solutions for MDS: Artificial Intelligence Techniques for Misuse Detection and Localisation in Telecommunication Environments
This report considers the application of Articial Intelligence (AI) techniques to
the problem of misuse detection and misuse localisation within telecommunications
environments. A broad survey of techniques is provided, that covers inter alia
rule based systems, model-based systems, case based reasoning, pattern matching,
clustering and feature extraction, articial neural networks, genetic algorithms, arti
cial immune systems, agent based systems, data mining and a variety of hybrid
approaches. The report then considers the central issue of event correlation, that
is at the heart of many misuse detection and localisation systems. The notion of
being able to infer misuse by the correlation of individual temporally distributed
events within a multiple data stream environment is explored, and a range of techniques,
covering model based approaches, `programmed' AI and machine learning
paradigms. It is found that, in general, correlation is best achieved via rule based approaches,
but that these suffer from a number of drawbacks, such as the difculty of
developing and maintaining an appropriate knowledge base, and the lack of ability
to generalise from known misuses to new unseen misuses. Two distinct approaches
are evident. One attempts to encode knowledge of known misuses, typically within
rules, and use this to screen events. This approach cannot generally detect misuses
for which it has not been programmed, i.e. it is prone to issuing false negatives.
The other attempts to `learn' the features of event patterns that constitute normal
behaviour, and, by observing patterns that do not match expected behaviour, detect
when a misuse has occurred. This approach is prone to issuing false positives,
i.e. inferring misuse from innocent patterns of behaviour that the system was not
trained to recognise. Contemporary approaches are seen to favour hybridisation,
often combining detection or localisation mechanisms for both abnormal and normal
behaviour, the former to capture known cases of misuse, the latter to capture
unknown cases. In some systems, these mechanisms even work together to update
each other to increase detection rates and lower false positive rates. It is concluded
that hybridisation offers the most promising future direction, but that a rule or state
based component is likely to remain, being the most natural approach to the correlation
of complex events. The challenge, then, is to mitigate the weaknesses of
canonical programmed systems such that learning, generalisation and adaptation
are more readily facilitated
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