Rotational linear discriminant analysis using Bayes Rule for dimensionality reduction

Linear discriminant analysis (LDA) finds an orientation that projects high dimensional feature vectors to reduced dimensional feature space in such a way that the overlapping between the classes in this feature space is minimum. This overlapping is usually finite and produces finite classification error which is further minimized by rotational LDA technique. This rotational LDA technique rotates the classes individually in the original feature space in a manner that enables further reduction of error. In this paper we present an extension of the rotational LDA technique by utilizing Bayes decision theory for class separation which improves the classification performance even further

A novel approach for breast ultrasound classification using two-dimensional empirical mode decomposition and multiple features

Aim: Breast cancer stands as a prominent cause of female mortality on a global scale, underscoring the critical need for precise and efficient diagnostic techniques. This research significantly enriches the body of knowledge pertaining to breast cancer classification, especially when employing breast ultrasound images, by introducing a novel method rooted in the two dimensional empirical mode decomposition (biEMD) method. In this study, an evaluation of the classification performance is proposed based on various texture features of breast ultrasound images and their corresponding biEMD subbands. Methods: A total of 437 benign and 210 malignant breast ultrasound images were analyzed, preprocessed, and decomposed into three biEMD sub-bands. A variety of features, including the Gray Level Co-occurrence Matrix (GLCM), Local Binary Patterns (LBP), and Histogram of Oriented Gradient (HOG), were extracted, and a feature selection process was performed using the least absolute shrinkage and selection operator method. The study employed GLCM, LBP and HOG, and machine learning techniques, including artificial neural networks (ANN), k-nearest neighbors (kNN), the ensemble method, and statistical discriminant analysis, to classify benign and malignant cases. The classification performance, measured through Area Under the Curve (AUC), accuracy, and F1 score, was evaluated using a 10-fold cross-validation approach. Results: The study showed that using the ANN method and hybrid features (GLCM+LBP+HOG) from BUS images' biEMD sub-bands led to excellent performance, with an AUC of 0.9945, an accuracy of 0.9644, and an F1 score of 0.9668. This has revealed the effectiveness of the biEMD method for classifying breast tumor types from ultrasound images. Conclusion: The obtained results have revealed the effectiveness of the biEMD method for classifying breast tumor types from ultrasound images, demonstrating high-performance classification using the proposed approach

Automated COVID-19 and Heart Failure Detection Using DNA Pattern Technique with Cough Sounds.

COVID-19 and heart failure (HF) are common disorders and although they share some similar symptoms, they require different treatments. Accurate diagnosis of these disorders is crucial for disease management, including patient isolation to curb infection spread of COVID-19. In this work, we aim to develop a computer-aided diagnostic system that can accurately differentiate these three classes (normal, COVID-19 and HF) using cough sounds. A novel handcrafted model was used to classify COVID-19 vs. healthy (Case 1), HF vs. healthy (Case 2) and COVID-19 vs. HF vs. healthy (Case 3) automatically using deoxyribonucleic acid (DNA) patterns. The model was developed using the cough sounds collected from 241 COVID-19 patients, 244 HF patients, and 247 healthy subjects using a hand phone. To the best our knowledge, this is the first work to automatically classify healthy subjects, HF and COVID-19 patients using cough sounds signals. Our proposed model comprises a graph-based local feature generator (DNA pattern), an iterative maximum relevance minimum redundancy (ImRMR) iterative feature selector, with classification using the k-nearest neighbor classifier. Our proposed model attained an accuracy of 100.0%, 99.38%, and 99.49% for Case 1, Case 2, and Case 3, respectively. The developed system is completely automated and economical, and can be utilized to accurately detect COVID-19 versus HF using cough sounds

Integrated smoothed location model and data reduction approaches for multi variables classification

Smoothed Location Model is a classification rule that deals with mixture of continuous variables and binary variables simultaneously. This rule discriminates groups in a parametric form using conditional distribution of the continuous variables given each pattern of the binary variables. To conduct a practical classification analysis, the objects must first be sorted into the cells of a multinomial table generated from the binary variables. Then, the parameters in each cell will be estimated using the sorted objects. However, in many situations, the estimated parameters are poor if the number of binary is large relative to the size of sample. Large binary variables will create too many multinomial cells which are empty, leading to high sparsity problem and finally give exceedingly poor performance for the constructed rule. In the worst case scenario, the rule cannot be constructed. To overcome such shortcomings, this study proposes new strategies to extract adequate variables that contribute to optimum performance of the rule. Combinations of two extraction techniques are introduced, namely 2PCA and PCA+MCA with new cutpoints of eigenvalue and total variance explained, to determine adequate extracted variables which lead to minimum misclassification rate. The outcomes from these extraction techniques are used to construct the smoothed location models, which then produce two new approaches of classification called 2PCALM and 2DLM. Numerical evidence from simulation studies demonstrates that the computed misclassification rate indicates no significant difference between the extraction techniques in normal and non-normal data. Nevertheless, both proposed approaches are slightly affected for non-normal data and severely affected for highly overlapping groups. Investigations on some real data sets show that the two approaches are competitive with, and better than other existing classification methods. The overall findings reveal that both proposed approaches can be considered as improvement to the location model, and alternatives to other classification methods particularly in handling mixed variables with large binary size

Face recognition using different training data.

Li Zhifeng.Thesis submitted in: December 2002.Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.Includes bibliographical references (leaves 49-53).Abstracts in English and Chinese.Abstract --- p.iAcknowledgments --- p.vTable of Contents --- p.viList of Figures --- p.viiiList of Tables --- p.ixChapter Chapter 1 --- Introduction --- p.1Chapter 1.1 --- Face Recognition Problem and Challenge --- p.1Chapter 1.2 --- Applications --- p.2Chapter 1.3 --- Face Recognition Methods --- p.3Chapter 1.4 --- The Relationship Between the Face Recognition Performance and Different Training Data --- p.5Chapter 1.5 --- Thesis Overview --- p.6Chapter Chapter 2 --- PCA-based Recognition Method --- p.7Chapter 2.1 --- Review --- p.7Chapter 2.2 --- Formulation --- p.8Chapter 2.2.1 --- Karhunen-Loeve transform (KLT) --- p.8Chapter 2.2.2 --- Multilevel Dominant Eigenvector Estimation (MDEE) --- p.12Chapter 2.3 --- Analysis of The Effect of Training Data on PCA-based Method --- p.13Chapter Chapter 3 --- LDA-based Recognition Method --- p.17Chapter 3.1 --- Review --- p.17Chapter 3.2 --- Formulation --- p.18Chapter 3.2.1 --- The Pure LDA --- p.18Chapter 3.2.2 --- LDA-based method --- p.19Chapter 3.3 --- Analysis of The Effect of Training Data on LDA-based Method --- p.21Chapter Chapter 4 --- Experiments --- p.23Chapter 4.1 --- Face Database --- p.23Chapter 4.1.1 --- AR face database --- p.23Chapter 4.1.2 --- XM2VTS face database --- p.24Chapter 4.1.3 --- MMLAB face database --- p.26Chapter 4.1.4 --- Face Data Preprocessing --- p.27Chapter 4.2 --- Recognition Formulation --- p.29Chapter 4.3 --- PCA-based Recognition Using Different Training Data Sets --- p.29Chapter 4.3.1 --- Experiments on MMLAB Face Database --- p.30Chapter 4.3.1.1 --- Training Data Sets and Testing Data Sets --- p.30Chapter 4.3.1.2 --- Face Recognition Performance Using Different Training Data Sets --- p.31Chapter 4.3.2 --- Experiments on XM2VTS Face Database --- p.33Chapter 4.3.3 --- Comparison of MDEE and KLT --- p.36Chapter 4.3.4 --- Summary --- p.38Chapter 4.4 --- LDA-based Recognition Using Different Training Data Sets --- p.38Chapter 4.4.1 --- Experiments on AR Face Database --- p.38Chapter 4.4.1.1 --- The Selection of Training Data and Testing Data --- p.38Chapter 4.4.1.2 --- LDA-based recognition on AR face database --- p.39Chapter 4.4.2 --- Experiments on XM2VTS Face Database --- p.40Chapter 4.4.3 --- Training Data Sets and Testing Data Sets --- p.41Chapter 4.4.4 --- Experiments on XM2VTS Face Database --- p.42Chapter 4.4.5 --- Summary --- p.46Chapter Chapter 5 --- Summary --- p.47Bibliography --- p.4

Non-invasive techniques for respiratory information extraction based on pulse photoplethysmogram and electrocardiogram

El objetivo principal de esta tesis es el desarrollo de métodos no invasivos para la extracción de información respiratoria a partir de dos señales biomédicas ampliamente utilizadas en la rutina clínica: el electrocardiograma (ECG) y la señal fotopletismográfica de pulso (PPG). La motivación de este estudio es la conveniencia de monitorizar información respiratoria a partir de dispositivos no invasivos que permita sustituir las técnicas actuales que podrían interferir con la respiración natural y que presentan inconvenientes en algunas aplicaciones como la prueba de esfuerzo y los estudios del sueño. Además, si estos dispositivos no invasivos son los ya utilizados en la rutina clínica, la información respiratoria extraída de ellos representa un valor añadido que permite tener una visión más completa del paciente. DESARROLLO TEÓRICO Esta tesis se divide en 6 capítulos. El Capítulo 1 introduce la problemática, motivaciones y objetivos del estudio. También introduce el origen fisiológico de las señales estudiadas ECG y PPG, y cómo y por qué tienen información autonómica y respiratoria que se puede extraer de ellas. El Capítulo 2 aborda la obtención de información respiratoria a partir del ECG. Se han propuesto varios métodos para la obtención de la respiración a partir del ECG (EDR, del inglés ¿ECG derived respiration?). Su rendimiento se suele ver muy afectado en entornos altamente no estacionarios y ruidosos como la prueba de esfuerzo. No obstante, se han propuesto algunas alternativas, como una basada en el ángulo de rotación del eje eléctrico (obtenido del ECG), que es el que mejor funciona en prueba de esfuerzo según nuestros conocimientos. Este método requiere de tres derivaciones ortogonales y es muy dependiente de cada una de ellas, i.e., el método no es aplicable o su rendimiento se reduce significativamente si hay algún problema en alguna de las derivaciones requeridas. En el Capítulo 2 se propone un método EDR nuevo basado en las pendientes del QRS y el ángulo de la onda R. El Capítulo 3 aborda a obtención de información respiratoria a partir de la señal PPG. Se propone un método nuevo para obtener la tasa respiratoria a partir de la señal PPG. Explota una modulación respiratoria en la variabilidad de anchura de pulso (PWV) relacionada con la velocidad y dispersión de la onda de pulso. El Capítulo 4 aborda la extracción de información respiratoria a partir de señales PPG registradas con smarthpones (SCPPG), mediante la adaptación de los métodos basados en la señal PPG presentados en el Capítulo 3. En el Capítulo 5 se propone un método para el diagnóstico del síndrome de apnea obstructiva del sueño (OSAS) en niños basado únicamente en la señal PPG. El OSAS es una disfunción relacionada con la respiración y el sueño que se diagnostica mediante polisomnografía (PSG). La PSG es el registro nocturno de muchas señales durante el sueño, siendo muy difícil de aplicar en entornos ambulatorios. El método que presenta esta tesis está enfocado a diagnosticar el OSAS en niños utilizando únicamente la señal PPG que permitiría considerar un diagnóstico ambulatorio con sus ventajas económicas y sociales. Finalmente, el Capítulo 6 resume las contribuciones originales y las conclusiones principales de esta tesis, y propone posibles extensiones del trabajo. CONCLUSIÓN El método presentado en el Capítulo 2 para estimar la tasa respiratoria a partir de las pendientes del complejo QRS y el ángulo de la onda R en el ECG demostró ser robusto en entornos altamente no estacionarios y ruidosos y por tanto ser aplicable durante ejercicio incluyendo entrenamiento deportivo. Además, es independiente de un conjunto específico de derivaciones y, por tanto, un problema en alguna de ellas no implica una reducción considerable del rendimiento. El método presentado en el Capítulo 3 para estimar la tasa respiratoria a partir de la PWV extraída de la señal PPG está mucho menos afectada por el tono simpático que otros métodos presentados en la literatura que suelen basarse en la amplitud y/o la tasa de pulso. Esto permite una mayor precisión que otros métodos basados en PPG. Además, se propone un método para combinar información de diferentes señales respiratorias, y se utiliza para estimar la tasa respiratoria a partir de la PWV en combinación con otros métodos basados en la señal PPG, mejorando la precisión de la estimación incluso en comparación con otros métodos en la literatura que requieren el ECG o la presión sanguínea. Los métodos propuestos en el Capítulo 4 para estimar la tasa respiratoria mediante señales SCPPG estimaron de forma precisa la tasa respiratoria en sus rangos espontáneos habituales (0.2-0.4 Hz) e incluso a tasas más altas (hasta 0.5 Hz o 0.6 Hz, dependiendo del dispositivo utilizado). El único requerimiento es que el smartphone tenga un luz tipo flash y una cámara para grabar una yema del dedo sobre ella. La popularidad de los smartphones los convierte en dispositivos de acceso y aceptación r¿apidos. Así, para la población general es potencialmente aceptable un método que funciona en smartphones, pudiendo facilitar la medida de algunas constantes vitales utilizando solo la yema del dedo. El método presentado en el Capítulo 5 para el diagnóstico del OSAS en niños a partir de la PPG obtuvo una precisión suficiente para la clínica, aunque antes de ser aplicado en dicho entorno, el método debería ser validado en una base de datos más grande.The main objective of this thesis is to develop non-invasive methods for respiration information extraction from two biomedical signals which are widely adopted in clinical routine: the electrocardiogram (ECG) and the pulse photoplethysmographic (PPG) signal. This study is motivated by the desirability of monitoring respiratory information from non-invasive devices allowing to substitute the current respiration-monitoring techniques which may interfere with natural breathing and which are unmanageable in some applications such as stress test or sleep studies. Furthermore, if these noninvasive devices are those already used in the clinical routine, the respiratory information obtained from them represents an added value which allows a more complete overview of the patient status. This thesis is divided into 6 chapters. Chapter 1 of this thesis introduces the problematic, motivations and objectives of this study. It also introduces the physiological origin of studied ECG and PPG signals, and why and how they carry autonomic- and respiration-related information which can be extracted from them. Chapter 2 of this thesis addresses the derivation of respiratory information from ECG signal. Several ECG derived respiration (EDR) methods have been presented in literature. Their performance usually decrease considerably in highly non-stationary and noisy environments such as stress test. However, some alternatives aimed to this kind of environments have been presented, such as one based on electrical axis rotation angles (obtained from the ECG), which to the best of our knowledge was the best suited for stress test. This method requires three orthogonal leads, and it is very dependent on each one of those leads, i.e., the performance of the method is significantly decreased if there is any problem at any one of the required leads. A novel EDR method based on QRS slopes and R-wave angle is presented in this thesis. The proposed method demonstrated to be robust in highly non-stationary and noisy environments and so to be applicable to exercise conditions including sports training. Furthermore, it is independent on a specific lead set, and so, a problem at any lead do not imply a significantly reduction of the performance. Chapter 3 addresses the derivation of respiratory information from PPG signals. A novel method for deriving respiratory rate from PPG signal is presented. It exploits respiration-related modulations in pulse width variability (PWV) which is related to pulse wave velocity and dispersion. The proposed method is much less affected by the sympathetic tone than other methods in literature which are usually based on pulses amplitude and/or rate. This leads to highest accuracy than other PPG-based method. Furthermore, a method for combining information from several respiratory signals was developed and used to obtain a respiratory rate estimation from the proposed PWV-based in combination with other known PPG-based methods, improving the accuracy of the estimation and outperforming other methods in literature which involve ECG or BP recording. Chapter 4 addresses the derivation of respiratory information from smartphone- camera-acquired-PPG (SCPPG) signals by adapting the methods for deriving respiratory rate from PPG signal presented in Chapter 3. The proposed method accurately estimates respiratory rate from SCPPG signals at its normal spontaneous ranges (0.2-0.4 Hz) and even at higher rates (up to 0.5 Hz or 0.6 Hz, depending on the used device). The only requirement is that these smartphones and tablets contain a flashlight and a video camera to image a fingertip pressed to it. As smartphones and tablets have become common, they meet the criteria of ready access and acceptance. Hence, a mobile phone/tablet approach has the potential to be widely-accepted by the general population and can facilitate the capability to measure some of the vital signs using only fingertip of the subject. Chapter 5 of this thesis proposes a methodology for obstructive sleep apnea syndrome (OSAS) screening in children just based on PPG signal. OSAS is a sleep-respiration-related dysfunction for which polysomnography (PSG) is the gold standard for diagnosis. PSG consists of overnight recording of many signals during sleep, therefore, it is quite involved and difficult to use in ambulatory scenario. The method presented in this thesis is aimed to diagnose the OSAS in children based just on PPG signal which would allow us to consider an ambulatory diagnosis with both its social and economic advantages. Finally, Chapter 6 summarizes the original contributions and main conclusions of the thesis, and proposes possible extensions of the work

Face recognition committee machine: methodology, experiments, and a system application.

Tang Ho-Man.Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.Includes bibliographical references (leaves 85-92).Abstracts in English and Chinese.Abstract --- p.iAcknowledgement --- p.ivChapter 1 --- Introduction --- p.1Chapter 1.1 --- Background --- p.1Chapter 1.2 --- Face Recognition --- p.2Chapter 1.3 --- Contributions --- p.4Chapter 1.4 --- Organization of this Thesis --- p.6Chapter 2 --- Literature Review --- p.8Chapter 2.1 --- Committee Machine --- p.8Chapter 2.1.1 --- Static Structure --- p.9Chapter 2.1.2 --- Dynamic Structure --- p.10Chapter 2.2 --- Face Recognition Algorithms Overview --- p.11Chapter 2.2.1 --- Eigenface --- p.12Chapter 2.2.2 --- Fisherface --- p.17Chapter 2.2.3 --- Elastic Graph Matching --- p.19Chapter 2.2.4 --- Support Vector Machines --- p.23Chapter 2.2.5 --- Neural Networks --- p.25Chapter 2.3 --- Commercial System and Applications --- p.27Chapter 2.3.1 --- FaceIT --- p.28Chapter 2.3.2 --- ZN-Face --- p.28Chapter 2.3.3 --- TrueFace --- p.29Chapter 2.3.4 --- Viisage --- p.30Chapter 3 --- Static Structure --- p.31Chapter 3.1 --- Introduction --- p.31Chapter 3.2 --- Architecture --- p.32Chapter 3.3 --- Result and Confidence --- p.33Chapter 3.3.1 --- "Eigenface, Fisherface, EGM" --- p.34Chapter 3.3.2 --- SVM --- p.35Chapter 3.3.3 --- Neural Networks --- p.36Chapter 3.4 --- Weight --- p.37Chapter 3.5 --- Voting Machine --- p.38Chapter 4 --- Dynamic Structure --- p.40Chapter 4.1 --- Introduction --- p.40Chapter 4.2 --- Architecture --- p.41Chapter 4.3 --- Gating Network --- p.42Chapter 4.4 --- Feedback Mechanism --- p.44Chapter 5 --- Face Recognition System --- p.46Chapter 5.1 --- Introduction --- p.46Chapter 5.2 --- System Architecture --- p.47Chapter 5.2.1 --- Face Detection Module --- p.48Chapter 5.2.2 --- Face Recognition Module --- p.49Chapter 5.3 --- Face Recognition Process --- p.50Chapter 5.3.1 --- Enrollment --- p.51Chapter 5.3.2 --- Recognition --- p.52Chapter 5.4 --- Distributed System --- p.54Chapter 5.4.1 --- Problems --- p.55Chapter 5.4.2 --- Distributed Architecture --- p.56Chapter 5.5 --- Conclusion --- p.59Chapter 6 --- Experimental Results --- p.60Chapter 6.1 --- Introduction --- p.60Chapter 6.2 --- Database --- p.61Chapter 6.2.1 --- ORL Face Database --- p.61Chapter 6.2.2 --- Yale Face Database --- p.62Chapter 6.2.3 --- AR Face Database --- p.62Chapter 6.2.4 --- HRL Face Database --- p.63Chapter 6.3 --- Experimental Details --- p.64Chapter 6.3.1 --- Pre-processing --- p.64Chapter 6.3.2 --- Cross Validation --- p.67Chapter 6.3.3 --- System details --- p.68Chapter 6.4 --- Result --- p.69Chapter 6.4.1 --- ORL Result --- p.69Chapter 6.4.2 --- Yale Result --- p.72Chapter 6.4.3 --- AR Result --- p.73Chapter 6.4.4 --- HRL Result --- p.75Chapter 6.4.5 --- Average Running Time --- p.76Chapter 6.5 --- Discussion --- p.77Chapter 6.5.1 --- Advantages --- p.78Chapter 6.5.2 --- Disadvantages --- p.79Chapter 6.6 --- Conclusion --- p.80Chapter 7 --- Conclusion --- p.82Bibliography --- p.9

A unified framework for subspace based face recognition.

Wang Xiaogang.Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.Includes bibliographical references (leaves 88-91).Abstracts in English and Chinese.Abstract --- p.iAcknowledgments --- p.vTable of Contents --- p.viList of Figures --- p.viiiList of Tables --- p.xChapter Chapter 1 --- Introduction --- p.1Chapter 1.1 --- Face recognition --- p.1Chapter 1.2 --- Subspace based face recognition technique --- p.2Chapter 1.3 --- Unified framework for subspace based face recognition --- p.4Chapter 1.4 --- Discriminant analysis in dual intrapersonal subspaces --- p.5Chapter 1.5 --- Face sketch recognition and hallucination --- p.6Chapter 1.6 --- Organization of this thesis --- p.7Chapter Chapter 2 --- Review of Subspace Methods --- p.8Chapter 2.1 --- PCA --- p.8Chapter 2.2 --- LDA --- p.9Chapter 2.3 --- Bayesian algorithm --- p.12Chapter Chapter 3 --- A Unified Framework --- p.14Chapter 3.1 --- PCA eigenspace --- p.16Chapter 3.2 --- Intrapersonal and extrapersonal subspaces --- p.17Chapter 3.3 --- LDA subspace --- p.18Chapter 3.4 --- Comparison of the three subspaces --- p.19Chapter 3.5 --- L-ary versus binary classification --- p.22Chapter 3.6 --- Unified subspace analysis --- p.23Chapter 3.7 --- Discussion --- p.26Chapter Chapter 4 --- Experiments on Unified Subspace Analysis --- p.28Chapter 4.1 --- Experiments on FERET database --- p.28Chapter 4.1.1 --- PCA Experiment --- p.28Chapter 4.1.2 --- Bayesian experiment --- p.29Chapter 4.1.3 --- Bayesian analysis in reduced PCA subspace --- p.30Chapter 4.1.4 --- Extract discriminant features from intrapersonal subspace --- p.33Chapter 4.1.5 --- Subspace analysis using different training sets --- p.34Chapter 4.2 --- Experiments on the AR face database --- p.36Chapter 4.2.1 --- "Experiments on PCA, LDA and Bayes" --- p.37Chapter 4.2.2 --- Evaluate the Bayesian algorithm for different transformation --- p.38Chapter Chapter 5 --- Discriminant Analysis in Dual Subspaces --- p.41Chapter 5.1 --- Review of LDA in the null space of and direct LDA --- p.42Chapter 5.1.1 --- LDA in the null space of --- p.42Chapter 5.1.2 --- Direct LDA --- p.43Chapter 5.1.3 --- Discussion --- p.44Chapter 5.2 --- Discriminant analysis in dual intrapersonal subspaces --- p.45Chapter 5.3 --- Experiment --- p.50Chapter 5.3.1 --- Experiment on FERET face database --- p.50Chapter 5.3.2 --- Experiment on the XM2VTS database --- p.53Chapter Chapter 6 --- Eigentransformation: Subspace Transform --- p.54Chapter 6.1 --- Face sketch recognition --- p.54Chapter 6.1.1 --- Eigentransformation --- p.56Chapter 6.1.2 --- Sketch synthesis --- p.59Chapter 6.1.3 --- Face sketch recognition --- p.61Chapter 6.1.4 --- Experiment --- p.63Chapter 6.2 --- Face hallucination --- p.69Chapter 6.2.1 --- Multiresolution analysis --- p.71Chapter 6.2.2 --- Eigentransformation for hallucination --- p.72Chapter 6.2.3 --- Discussion --- p.75Chapter 6.2.4 --- Experiment --- p.77Chapter 6.3 --- Discussion --- p.83Chapter Chapter 7 --- Conclusion --- p.85Publication List of This Thesis --- p.87Bibliography --- p.8

Multimodal Signal Processing for Diagnosis of Cardiorespiratory Disorders

This thesis addresses the use of multimodal signal processing to develop algorithms for the automated processing of two cardiorespiratory disorders. The aim of the first application of this thesis was to reduce false alarm rate in an intensive care unit. The goal was to detect five critical arrhythmias using processing of multimodal signals including photoplethysmography, arterial blood pressure, Lead II and augmented right arm electrocardiogram (ECG). A hierarchical approach was used to process the signals as well as a custom signal processing technique for each arrhythmia type. Sleep disorders are a prevalent health issue, currently costly and inconvenient to diagnose, as they normally require an overnight hospital stay by the patient. In the second application of this project, we designed automated signal processing algorithms for the diagnosis of sleep apnoea with a main focus on the ECG signal processing. We estimated the ECG-derived respiratory (EDR) signal using different methods: QRS-complex area, principal component analysis (PCA) and kernel PCA. We proposed two algorithms (segmented PCA and approximated PCA) for EDR estimation to enable applying the PCA method to overnight recordings and rectify the computational issues and memory requirement. We compared the EDR information against the chest respiratory effort signals. The performance was evaluated using three automated machine learning algorithms of linear discriminant analysis (LDA), extreme learning machine (ELM) and support vector machine (SVM) on two databases: the MIT PhysioNet database and the St. Vincent’s database. The results showed that the QRS area method for EDR estimation combined with the LDA classifier was the highest performing method and the EDR signals contain respiratory information useful for discriminating sleep apnoea. As a final step, heart rate variability (HRV) and cardiopulmonary coupling (CPC) features were extracted and combined with the EDR features and temporal optimisation techniques were applied. The cross-validation results of the minute-by-minute apnoea classification achieved an accuracy of 89%, a sensitivity of 90%, a specificity of 88%, and an AUC of 0.95 which is comparable to the best results reported in the literature