Roadmap on label-free super-resolution imaging

Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field

Sex! Aliens! Harvard? Rhetorical boundary-work in the media (a case study of the role of journalists in the social construction of scientific authority)

Thesis (PhD) - Indiana University, Journalism, 2005With science and the media playing prominent roles in contemporary life, it is important to understand the cultural authority of science and the role of the media in maintaining this authority. This paper will report on a case study of journalists' participation in the social construction of scientific authority. The case involves print media coverage of controversial scientific research conducted by a tenured professor of psychiatry at Harvard Medical School, a Pulitzer Prize winner, and a well-known authority in his field. When this elite scientist embarked upon the study of people who believe they have been abducted by aliens he drew fire for stepping outside the boundaries of "real" science, despite his stellar credentials and long history of accomplishment. Much of this fire took place on the field of the mass media. The boundaries of science and scientific authority were tested in this case, and journalists played a role in the boundary-work. Employing the sensitizing concept of boundary-work to guide analysis of media content, this case study explores how journalists constructed scientific authority in their coverage of Mack's abduction research, and to what ends, and how scientific and journalistic norms operate in media coverage of science. Rhetoric is a primary tool for constructing social reality, and the rhetoric of science is a key source -- for the purposes of this study, arguably the sole source -- of the cultural authority of science. Burke's dramatistic criticism is thus employed as a primary analytic tool in this study, to excavate the landscape of symbolic communication. The aim of this study is to illuminate ambiguity, complexity, motives and meanings in this case. It is intended to be thought provoking, instructive, and productive, to enrich the ongoing examination of the cultural roles of science and journalism

Roadmap on Label-Free Super-resolution Imaging

Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.Peer reviewe

Medical Humanity and Inhumanity in the German-Speaking World

Medical Humanity and Inhumanity in the German-Speaking World is the first volume dedicated to exploring the interface of medicine, the human and the humane in the German-speaking lands. The volume tracks the designation and making through medicine of the human and inhuman, and the humane and inhumane, from the Middle Ages to the present day. Eight individual chapters undertake explorations into ways in which theories and practices of medicine in the German-speaking world have come to define the human, and highlight how such theories and practices have consolidated, or undermined, notions of humane behaviour. Cultural analysis is central to this investigation, foregrounding the reflection, refraction and indeed creation of these theories and practices in literature, life-writing and other discourses and media. Contributors bring to bear perspectives from literary studies, film studies, critical theory, cultural studies, history, and the history of medicine and psychiatry. Thus, this collection is historical in the most expansive sense, for it debates not only what historical accounts bring to our understanding of this topic. It encompasses too investigation of life-writing, documentary, and theory and literary works to bring to light elusive, paradoxical, underexplored – yet vital – issues in history and culture

Script Effects as the Hidden Drive of the Mind, Cognition, and Culture

This open access volume reveals the hidden power of the script we read in and how it shapes and drives our minds, ways of thinking, and cultures. Expanding on the Linguistic Relativity Hypothesis (i.e., the idea that language affects the way we think), this volume proposes the “Script Relativity Hypothesis” (i.e., the idea that the script in which we read affects the way we think) by offering a unique perspective on the effect of script (alphabets, morphosyllabaries, or multi-scripts) on our attention, perception, and problem-solving. Once we become literate, fundamental changes occur in our brain circuitry to accommodate the new demand for resources. The powerful effects of literacy have been demonstrated by research on literate versus illiterate individuals, as well as cross-scriptal transfer, indicating that literate brain networks function differently, depending on the script being read. This book identifies the locus of differences between the Chinese, Japanese, and Koreans, and between the East and the West, as the neural underpinnings of literacy. To support the “Script Relativity Hypothesis”, it reviews a vast corpus of empirical studies, including anthropological accounts of human civilization, social psychology, cognitive psychology, neuropsychology, applied linguistics, second language studies, and cross-cultural communication. It also discusses the impact of reading from screens in the digital age, as well as the impact of bi-script or multi-script use, which is a growing trend around the globe. As a result, our minds, ways of thinking, and cultures are now growing closer together, not farther apart. ; Examines the origin, emergence, and co-evolution of written language, the human mind, and culture within the purview of script effects Investigates how the scripts we read over time shape our cognition, mind, and thought patterns Provides a new outlook on the four representative writing systems of the world Discusses the consequences of literacy for the functioning of the min

Is attention both necessary and sufficient for consciousness?

Theoretical thesis.Bibliography: pages 399-436.1. Q: Is attention both necessary and sufficient for consciousness? -- PART I. (RE-) LAYING THE FOUNDATIONS: 2. Phenomenal consciousness -- 3. The many faces of attention -- 4. Relationships -- 5. Working memory -- PART II. ADDRESSING Q: 6. Pulling attention and consciousness apart -- 7. Phenomenal overflow -- 8. Triangulating capacity limitations -- 9. Answer(s) to Q -- Appendices -- BibliographyIs attention both necessary and sufficient for consciousness? Call this central question of this treatise, "Q." We commonly have the experience of consciously paying attention to something, but is it possible to be conscious of something you are not attending to, or to attend to something of which you are not conscious? Where might we find examples of these? This treatise is a quest to find an answer to Q in two parts. Part I reviews the foundations upon which the discourse on Q is built. Different inputs to Q produce different answers. After consideration of the many ways "attention" and "consciousness" have been defined, I settle upon phenomenal consciousness and Executive Attention (defined as a suite of strategies for structuring cognition for further processing implemented by the executive of working memory) as the most interesting inputs to Q, and the ones on which Part II focuses. Attention without consciousness seems relatively easy to establish empirically, but consciousness without attention is much harder. The putative candidates all seem to have major problems, but I build a strong abductive case for the hitherto ignored case of foveal phenomenal overflow. We consciously see far more detail in our foveal fields than we can Executively Attend, although there is a serious obstacle to our ever confirming that empirically - identifying conscious content relies on Executive Attentional report. Triangulating the capacity limitations of attention, consciousness, and working memory strengthens this case for consciousness without attention, and suggests that cognition must work something like my "Witches' Hat Model," on which con tent can become conscious outside of Executive Attention or working memory. I conclude with some reflections on the implications of my arguments for the discourse on Q, and for other discourses such as the ontologies of attention and consciousness, theories of consciousness, some other cognitive concepts, and ethical considerations in humans, animals, and machines. A conclusive answer to Q continue s to elude us. It may perhaps be an ultimately insoluble conundrum. But it is the very essence of humanity to seek an answer, and in so doing, to improve our understanding of our own nature : "The proper study of mankind is man."1 online resource (436 pages