34,042 research outputs found
Robustness of Trans-European Gas Networks
Here we uncover the load and fault-tolerant backbones of the trans-European
gas pipeline network. Combining topological data with information on
inter-country flows, we estimate the global load of the network and its
tolerance to failures. To do this, we apply two complementary methods
generalized from the betweenness centrality and the maximum flow. We find that
the gas pipeline network has grown to satisfy a dual-purpose: on one hand, the
major pipelines are crossed by a large number of shortest paths thereby
increasing the efficiency of the network; on the other hand, a non-operational
pipeline causes only a minimal impact on network capacity, implying that the
network is error-tolerant. These findings suggest that the trans-European gas
pipeline network is robust, i.e., error tolerant to failures of high load
links.Comment: 11 pages, 8 figures (minor changes
Graph analysis of functional brain networks: practical issues in translational neuroscience
The brain can be regarded as a network: a connected system where nodes, or
units, represent different specialized regions and links, or connections,
represent communication pathways. From a functional perspective communication
is coded by temporal dependence between the activities of different brain
areas. In the last decade, the abstract representation of the brain as a graph
has allowed to visualize functional brain networks and describe their
non-trivial topological properties in a compact and objective way. Nowadays,
the use of graph analysis in translational neuroscience has become essential to
quantify brain dysfunctions in terms of aberrant reconfiguration of functional
brain networks. Despite its evident impact, graph analysis of functional brain
networks is not a simple toolbox that can be blindly applied to brain signals.
On the one hand, it requires a know-how of all the methodological steps of the
processing pipeline that manipulates the input brain signals and extract the
functional network properties. On the other hand, a knowledge of the neural
phenomenon under study is required to perform physiological-relevant analysis.
The aim of this review is to provide practical indications to make sense of
brain network analysis and contrast counterproductive attitudes
Performance analysis of a parallel, multi-node pipeline for DNA sequencing
Post-sequencing DNA analysis typically consists of read mapping followed by variant calling and is very time-consuming, even on a multi-core machine. Recently, we proposed Halvade, a parallel, multi-node implementation of a DNA sequencing pipeline according to the GATK Best Practices recommendations. The MapReduce programming model is used to distribute the workload among different workers. In this paper, we study the impact of different hardware configurations on the performance of Halvade. Benchmarks indicate that especially the lack of good multithreading capabilities in the existing tools (BWA, SAMtools, Picard, GATK) cause suboptimal scaling behavior. We demonstrate that it is possible to circumvent this bottleneck by using multiprocessing on high-memory machines rather than using multithreading. Using a 15-node cluster with 360 CPU cores in total, this results in a runtime of 1 h 31 min. Compared to a single-threaded runtime of similar to 12 days, this corresponds to an overall parallel efficiency of 53%
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