Web Engineering for Workflow-based Applications: Models, Systems and Methodologies

This dissertation presents novel solutions for the construction of Workflow-based Web applications: The Web Engineering DSL Framework, a stakeholder-oriented Web Engineering methodology based on Domain-Specific Languages; the Workflow DSL for the efficient engineering of Web-based Workflows with strong stakeholder involvement; the Dialog DSL for the usability-oriented development of advanced Web-based dialogs; the Web Engineering Reuse Sphere enabling holistic, stakeholder-oriented reuse

A Blueprint for Knowledge Management in the Biopharmaceutical Sector

This research examined current industry Knowledge Management (KM) methodologies and capabilities in order to gain insights into the level of maturity and understanding of KM within the biopharmaceutical sector. In addition, the researcher has developed models, tools and processes that can assist the sector to gain greater clarity of the value and merits that KM can offer to organizations. The researcher proposes that a systematic KM program can be used to “unlock” the knowledge and organizational capabilities necessary to convey real competitive advantage, but more importantly for the patient, to enable organizations to successfully develop and deliver the next generation of advanced therapeutics. The research questions asked; What are the current levels of adoption of KM within the biopharmaceutical sector? How is ‘critical knowledge’ defined within organizations? What might represent the core elements of a Pharma KM Blueprint to better enable knowledge flow within organizations? The research approach adopted a pragmatic worldview which is most suited to a research topic that is both real world practice orientated and problemcentered and sought to examine the consequences of actions within the biopharmaceutical sector when knowledge is not managed effectively. There were three primary phases of inquiry employed in the thesis and a mixed methods approach was used to explore the problems addressed. The first phase involved quantitative and qualitative data analysis of relevant literature sources, including available international KM benchmarking data. The second phase involved a biopharmaceutical industry consultation phase comprising of focus groups, polls and philosophical dialogues with KM experts, sector KM practitioners and knowledge workers. The third and final phase of inquiry involved the adaptation and development of the Pharma KM Blueprint including practical KM tools, frameworks and models for use within the biopharmaceutical sector. This phase also included a detailed case study executed within one large biopharmaceutical organization of a KM diagnostic tool and process developed as part of this research. The research findings have established a core principle that knowledge must be valued and managed as a critical asset within an organization, in the same manner as physical assets. In addition, the research identified that in order to realize the ambitions of ICH Q10, stated as, ‘enhance the quality and availability of medicines around the world in the interest of public health’, (ICH Q10, 2008), there is a crucial need to enhance the effective and efficient flow of knowledge across the product lifecycle within organizations. The research finds that in order to extract value from this organizational knowledge there must be practical, integrated and systematic KM approaches implemented for the identification, capture, curation and visibility of the critical knowledge assets before the matter of enhancing the flow of knowledge can be addressed. The research indicates that while these concepts are important to any business within the traditional biopharmaceutical sector planning on remaining competitive, they represent a “game changer” (or “game over”) opportunity for any organization planning to develop, manufacture or market advanced therapeutic products, personalized medicines or next generation products. A key output of the research is the Pharma KM Blueprint that illustrates the holistic integration of core KM principles, models and tools to deliver the real benefits to the patients and the business

Web engineering for workflow-based applications: models, systems and methodologies

Workflow-based Web applications present a central pillar of companies\u27 endeavors towards increased business process efficiency and flexibility. Considering their particular characteristics, this book presents innovative approaches for their efficient, completely model-driven construction with particular emphasis on effective stakeholder involvement, usability-oriented dialog design and cross-methodological reuse

Social Enterprise Places:a place-based initiative facilitating syntactic, semantic and pragmatic constructions of legitimacy

Social Enterprises are becoming a significant force of social as well as economic good despite facing many difficulties that are brought about by their unique characteristics. Chief among these is the question of their perceived legitimacy that impinges upon their ability to gain funding, acquire contracts and appear as capable organisations to potential partnering institutions. This study explores the means by which Social Enterprises are legitimized through participation in the Social Enterprise Place (SEP) programme in the UK. By examining the Boundary Objects (BO) that span the intersections of the incumbent social groups it identifies three pillars upon which SEPs have facilitated SE legitimacy. These pillars comprise (i) the place-based language (syntactic BO), that enables the identification of (ii) common social goals (semantic BOs), and thereby enables the (iii) mobilization of resources toward their resolution (pragmatic BOs). This research provides insight into the facilitation of legitimacy for Social Enterprises that are engaged in a place-based initiative. By responding to Peterson’s (2016) call for macromarketers to take more note of meso level marketing dynamics in different industries the paper highlights the potential for place to facilitate the legitimacy of SEs. In addition, it reveals a further macromarketing dimension to Boundary Object plasticity whereby they may evolve through syntactic, semantic and pragmatic forms over time

Challenges and Opportunities in Applied System Innovation

This book introduces and provides solutions to a variety of problems faced by society, companies and individuals in a quickly changing and technology-dependent world. The wide acceptance of artificial intelligence, the upcoming fourth industrial revolution and newly designed 6G technologies are seen as the main enablers and game changers in this environment. The book considers these issues not only from a technological viewpoint but also on how society, labor and the economy are affected, leading to a circular economy that affects the way people design, function and deploy complex systems

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine