Achieving the Way for Automated Segmentation of Nuclei in Cancer Tissue Images through Morphology-Based Approach: a Quantitative Evaluation

In this paper we address the problem of nuclear segmentation in cancer tissue images, that is critical for specific protein activity quantification and for cancer diagnosis and therapy. We present a fully automated morphology-based technique able to perform accurate nuclear segmentations in images with heterogeneous staining and multiple tissue layers and we compare it with an alternate semi-automated method based on a well established segmentation approach, namely active contours. We discuss active contours’ limitations in the segmentation of immunohistochemical images and we demonstrate and motivate through extensive experiments the better accuracy of our fully automated approach compared to various active contours implementations

Variational Deep Semantic Hashing for Text Documents

As the amount of textual data has been rapidly increasing over the past decade, efficient similarity search methods have become a crucial component of large-scale information retrieval systems. A popular strategy is to represent original data samples by compact binary codes through hashing. A spectrum of machine learning methods have been utilized, but they often lack expressiveness and flexibility in modeling to learn effective representations. The recent advances of deep learning in a wide range of applications has demonstrated its capability to learn robust and powerful feature representations for complex data. Especially, deep generative models naturally combine the expressiveness of probabilistic generative models with the high capacity of deep neural networks, which is very suitable for text modeling. However, little work has leveraged the recent progress in deep learning for text hashing. In this paper, we propose a series of novel deep document generative models for text hashing. The first proposed model is unsupervised while the second one is supervised by utilizing document labels/tags for hashing. The third model further considers document-specific factors that affect the generation of words. The probabilistic generative formulation of the proposed models provides a principled framework for model extension, uncertainty estimation, simulation, and interpretability. Based on variational inference and reparameterization, the proposed models can be interpreted as encoder-decoder deep neural networks and thus they are capable of learning complex nonlinear distributed representations of the original documents. We conduct a comprehensive set of experiments on four public testbeds. The experimental results have demonstrated the effectiveness of the proposed supervised learning models for text hashing.Comment: 11 pages, 4 figure

Detail-preserving and Content-aware Variational Multi-view Stereo Reconstruction

Accurate recovery of 3D geometrical surfaces from calibrated 2D multi-view images is a fundamental yet active research area in computer vision. Despite the steady progress in multi-view stereo reconstruction, most existing methods are still limited in recovering fine-scale details and sharp features while suppressing noises, and may fail in reconstructing regions with few textures. To address these limitations, this paper presents a Detail-preserving and Content-aware Variational (DCV) multi-view stereo method, which reconstructs the 3D surface by alternating between reprojection error minimization and mesh denoising. In reprojection error minimization, we propose a novel inter-image similarity measure, which is effective to preserve fine-scale details of the reconstructed surface and builds a connection between guided image filtering and image registration. In mesh denoising, we propose a content-aware $\ell_{p}$-minimization algorithm by adaptively estimating the $p$ value and regularization parameters based on the current input. It is much more promising in suppressing noise while preserving sharp features than conventional isotropic mesh smoothing. Experimental results on benchmark datasets demonstrate that our DCV method is capable of recovering more surface details, and obtains cleaner and more accurate reconstructions than state-of-the-art methods. In particular, our method achieves the best results among all published methods on the Middlebury dino ring and dino sparse ring datasets in terms of both completeness and accuracy.Comment: 14 pages,16 figures. Submitted to IEEE Transaction on image processin