71 research outputs found

    Characterization of Pharmaceutical Tablets by X-ray Tomography

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    Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry

    Artist profiling using micro-CT scanning of a Rijksmuseum terracotta sculpture

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    In the fine arts, impressions found on terracotta sculptures in museum collections are scarcely reported and not in a systematic manner. Here, we present a procedure for scanning fingermarks and toolmarks found on the visible surface and inner walls of a terracotta sculpture using 3D micro-computed tomography, as well as methods for quantitatively characterizing these impressions. We apply our pipeline on the terracotta sculpture Study for a Hovering Putto, attributed to Laurent Delvaux and housed in the Rijksmuseum collection. On the basis of combined archaeology and forensics research that assigns age groups to makers of European ancestry from ridge breadth values, we estimate that the fingermarks belong to an adult male. Given that each fingerprint is unique and the carving tools were exclusively made in the artist's workshop, we give incentive to aim for artist profiling using innovative computational approaches on preserved impressions from terracotta sculptures

    Understanding Quantum Technologies 2022

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    Understanding Quantum Technologies 2022 is a creative-commons ebook that provides a unique 360 degrees overview of quantum technologies from science and technology to geopolitical and societal issues. It covers quantum physics history, quantum physics 101, gate-based quantum computing, quantum computing engineering (including quantum error corrections and quantum computing energetics), quantum computing hardware (all qubit types, including quantum annealing and quantum simulation paradigms, history, science, research, implementation and vendors), quantum enabling technologies (cryogenics, control electronics, photonics, components fabs, raw materials), quantum computing algorithms, software development tools and use cases, unconventional computing (potential alternatives to quantum and classical computing), quantum telecommunications and cryptography, quantum sensing, quantum technologies around the world, quantum technologies societal impact and even quantum fake sciences. The main audience are computer science engineers, developers and IT specialists as well as quantum scientists and students who want to acquire a global view of how quantum technologies work, and particularly quantum computing. This version is an extensive update to the 2021 edition published in October 2021.Comment: 1132 pages, 920 figures, Letter forma

    THIESEL 2022. Conference on Thermo-and Fluid Dynamics of Clean Propulsion Powerplants

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    The THIESEL 2022. Conference on Thermo-and Fluid Dynamic Processes in Direct Injection Engines planned in Valencia (Spain) for 8th to 11th September 2020 has been successfully held in a virtual format, due to the COVID19 pandemic. In spite of the very tough environmental demands, combustion engines will probably remain the main propulsion system in transport for the next 20 to 50 years, at least for as long as alternative solutions cannot provide the flexibility expected by customers of the 21st century. But it needs to adapt to the new times, and so research in combustion engines is nowadays mostly focused on the new challenges posed by hybridization and downsizing. The topics presented in the papers of the conference include traditional ones, such as Injection & Sprays, Combustion, but also Alternative Fuels, as well as papers dedicated specifically to CO2 Reduction and Emissions Abatement.Papers stem from the Academic Research sector as well as from the IndustryXandra Marcelle, M.; Payri Marín, R.; Serrano Cruz, JR. (2022). THIESEL 2022. Conference on Thermo-and Fluid Dynamics of Clean Propulsion Powerplants. Editorial Universitat Politècnica de València. https://doi.org/10.4995/Thiesel.2022.632801EDITORIA

    Computational Modelling of Concrete and Concrete Structures

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    Computational Modelling of Concrete and Concrete Structures contains the contributions to the EURO-C 2022 conference (Vienna, Austria, 23-26 May 2022). The papers review and discuss research advancements and assess the applicability and robustness of methods and models for the analysis and design of concrete, fibre-reinforced and prestressed concrete structures, as well as masonry structures. Recent developments include methods of machine learning, novel discretisation methods, probabilistic models, and consideration of a growing number of micro-structural aspects in multi-scale and multi-physics settings. In addition, trends towards the material scale with new fibres and 3D printable concretes, and life-cycle oriented models for ageing and durability of existing and new concrete infrastructure are clearly visible. Overall computational robustness of numerical predictions and mathematical rigour have further increased, accompanied by careful model validation based on respective experimental programmes. The book will serve as an important reference for both academics and professionals, stimulating new research directions in the field of computational modelling of concrete and its application to the analysis of concrete structures. EURO-C 2022 is the eighth edition of the EURO-C conference series after Innsbruck 1994, Bad Gastein 1998, St. Johann im Pongau 2003, Mayrhofen 2006, Schladming 2010, St. Anton am Arlberg 2014, and Bad Hofgastein 2018. The overarching focus of the conferences is on computational methods and numerical models for the analysis of concrete and concrete structures

    Eleventh International Conference on the Bearing Capacity of Roads, Railways and Airfields

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    Innovations in Road, Railway and Airfield Bearing Capacity – Volume 2 comprises the second part of contributions to the 11th International Conference on Bearing Capacity of Roads, Railways and Airfields (2022). In anticipation of the event, it unveils state-of-the-art information and research on the latest policies, traffic loading measurements, in-situ measurements and condition surveys, functional testing, deflection measurement evaluation, structural performance prediction for pavements and tracks, new construction and rehabilitation design systems, frost affected areas, drainage and environmental effects, reinforcement, traditional and recycled materials, full scale testing and on case histories of road, railways and airfields. This edited work is intended for a global audience of road, railway and airfield engineers, researchers and consultants, as well as building and maintenance companies looking to further upgrade their practices in the field
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