Pearl and the medieval dream vision

Based on Classical and Biblical authorities, many medieval writers used the dream vision, either as a literary device, political subversion or as a way of conveying a mystical experience. In some ways the dream vision negated responsibility from the material they were conveying. This paper considers some uses of the medieval dream vision, with particular reference to the devotional, elegiac poem, Pear

Narcolepsy and emotional experience: a review of the literature

Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis. This disease affects significantly the overall patient functioning, interfering with social, work, and affective life. Some symptoms of narcolepsy depend on emotional stimuli; for instance, cataplectic attacks can be triggered by emotional inputs such as laughing, joking, a pleasant surprise, and also anger. Neurophysiological and neurochemical findings suggest the involvement of emotional brain circuits in the physiopathology of cataplexy, which seems to depending on the dysfunctional interplay between the hypothalamus and the amygdala associated with an alteration of hypocretin levels. Furthermore, behavioral studies suggest an impairment of emotions processing in narcolepsy-cataplexy (NC), like a probable coping strategy to avoid or reduce the frequency of cataplexy attacks. Consistently, NC patients seem to use coping strategies even during their sleep, avoiding unpleasant mental sleep activity through lucid dreaming. Interestingly, NC patients, even during sleep, have a different emotional experience than healthy subjects, with more vivid, bizarre, and frightening dreams. Notwithstanding this evidence, the relationship between emotion and narcolepsy is poorly investigated. This review aims to provide a synthesis of behavioral, neurophysiological, and neurochemical evidence to discuss the complex relationship between NC and emotional experience and to direct future research

The Evolving Human and Dream-like, Screen-based Media

With rare exceptions, film theorists have traditionally focussed on culturally symbolic criticism in a persistent denial of the biological function and benefit of film-going. There has been a recent reversal of this trend, however, with the development of a cognitive theory of film, which Nicolas Tredell describes as an approach whereby "A film can be regarded as a simulation of a (possible) real-life situation that engages the viewer’s intellect, emotions and body, and that involves a complex negotiation between fiction and reality" (2002: 259). One aspect of this attempt to include science in the understanding of film has been neoteric work by William Evans on the evolutionary aspects of film-going. He argues that "humans have evolved to prefer television and film to print media [… because] it seems real to us [and because] humans are hardwired to attend and respond to visual stimuli, especially when visual stimuli include other people [...] engaging in salient behaviour" (2005: 200-201). But this elegantly simple explanation of the evolutionary significance of film and other screen-based media needs further elaboration. Firstly, Evans fails to consider the evolutionary benefits that accrue from Revonsuo's 2005 theory of the threat rehearsal function of film-going, in that films are like dreams. Secondly, in emphasizing the reality of the screen's moving image, he neglects to consider why humans attend to unrealistic film such as animations, which I argue are even more dream-like than non-animated films, using the example of Walt Disney's Fantasia (1940). Thirdly, he omits consideration of the evolutionary function of a film auteur who is assigned the virtual status of tribal elder. Hence I make a tendentious claim regarding the evolutionary benefit of film-goers assigning the status of 'auteur' to an individual writer/director, despite the well known collaborative nature of film-making, and (dare I say) the out-of-fashion Barthesian notion of the death of the author. Regarding Disney once again, one notes the absence of certain genres of cinema in his otherwise heterogeneous body of work: he has never made a war film or action movie. Such exclusions, only apparent when the huge oeuvre he has helmed are considered as a single text emanating from an individual author, generate an understanding of the Disney worldview, in which family values are prioritised and prompts attitudes toward this auteurial individual akin to meaning-seeking villagers genuflecting to a wise tribal elder as he offers advice for survival of the species in the evolutionary struggle for survival of the fittest. In addressing these three omissions, my paper aims to gain credibility for a more comprehensive evolutionary theory of film

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression.

The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, including areas such as the dorsal (DR) and median (MR) raphe nuclei, which are involved in the control of sleep and mood. Major Depression (MD) is a prevalent psychiatric disease diagnosed on the basis of symptomatic criteria such as sadness or melancholia, guilt, irritability, and anhedonia. A short REM sleep latency (i.e., the interval between sleep onset and the first REM sleep period), as well as an increase in the duration of REM sleep and the density of rapid-eye movements during this state, are considered important biological markers of depression. The fact that the greatest firing rate of MCHergic neurons occurs during REM sleep and that optogenetic stimulation of these neurons induces sleep, tends to indicate that MCH plays a critical role in the generation and maintenance of sleep, especially REM sleep. In addition, the acute microinjection of MCH into the DR promotes REM sleep, while immunoneutralization of this peptide within the DR decreases the time spent in this state. Moreover, microinjections of MCH into either the DR or MR promote a depressive-like behavior. In the DR, this effect is prevented by the systemic administration of antidepressant drugs (either fluoxetine or nortriptyline) and blocked by the intra-DR microinjection of a specific MCH receptor antagonist. Using electrophysiological and microdialysis techniques we demonstrated also that MCH decreases the activity of serotonergic DR neurons. Therefore, there are substantive experimental data suggesting that the MCHergic system plays a role in the control of REM sleep and, in addition, in the pathophysiology of depression. Consequently, in the present report, we summarize and evaluate the current data and hypotheses related to the role of MCH in REM sleep and MD

Bulletin of the Center for Children's Books 29 (06) 1976

published or submitted for publicatio

Writing biology with mutant mice: the monstrous potential of post genomic life

Social scientific accounts identified in the biological grammars of early genomics a monstrous reductionism, ‘an example of brute life, the minimalist essence of things’ (Rabinow, 1996, p. 89). Concern about this reductionism focused particularly on its links to modernist notions of control; the possibility of calculating, predicting and intervening in the biological futures of individuals and populations. Yet, the trajectories of the post genomic sciences have not unfolded in this way, challenging scientists involved in the production and integration of complex biological data and the interpretative strategies of social scientists honed in critiquing this reductionism. The post genomic sciences are now proliferating points from which to understand relations in biology, between genes and environments, as well as between species and spaces, opening up future possibilities and different ways of thinking about life. This paper explores the emerging topologies and temporalities of one form of post genomic research, drawing upon ethnographic research on international efforts in functional genomics, which are using mutant mice to understand mammalian gene function. Using vocabularies on the monstrous from Derrida and Haraway, I suggest an alternative conceptualisation of monstrosity within biology, in which the ascendancy of mice in functional genomics acts as a constant supplement to the reductionist grammars of genomics. Rather than searching for the minimalist essence of things, this form of functional genomics has become an exercise in the production and organization of biological surplus and excess, which is experimental, corporeal and affective. The uncertain functioning of monsters in this contexts acts as a generative catalyst for scientists and social scientists, proliferating perspectives from which to listen to and engage with the mutating landscapes, forms of life, and languages of a post genomic biology

The functional role of dreaming in emotional processes

Dream experience (DE) represents a fascinating condition linked to emotional processes and the human inner world. Although the overlap between REM sleep and dreaming has been overcome, several studies point out that emotional and perceptually vivid contents are more frequent when reported upon awakenings from this sleep stage. Actually, it is well-known that REM sleep plays a pivotal role in the processing of salient and emotional waking-life experiences, strongly contributing to the emotional memory consolidation. In this vein, we highlighted that, to some extent, neuroimaging studies showed that the processes that regulate dreaming and emotional salience in sleep mentation share similar neural substrates of those controlling emotions during wakefulness. Furthermore, the research on EEG correlates of the presence/absence of DE and the results on EEG pattern related to the incorporated memories converged to assign a crucial role of REM theta oscillations in emotional re-processing. In particular, the theta activity is involved in memory processes during REM sleep as well as during the waking state, in line with the continuity hypothesis. Also, the gamma activity seems to be related to emotional processes and dream recall as well as to lucid dreams. Interestingly, similar EEG correlates of DE have been found in clinical samples when nightmares or dreams occur. Research on clinical samples revealed that promoting the rehearsal of frightening contents aimed to change them is a promising method to treat nightmares, and that lucid dreams are associated with an attenuation of nightmares. In this view, DE can defuse emotional traumatic memories when the emotional regulation and the fear extinction mechanisms are compromised by traumatic and frightening events. Finally, dreams could represent a sort of simulation of reality, providing the possibility to create a new scenario with emotional mastery elements to cope with dysphoric items included in nightmares. In addition, it could be hypothesized that the insertion of bizarre items besides traumatic memories might be functional to “impoverish” the negative charge of the experiences