Diagnosing and measuring incompatibilities between pairs of services

International audienceThis text presents a tool, from its design to its implementation, which detects all behavioural incompatibilities between two service interfaces. Unlike prior work, the proposed solution does not simply check whether two services are incompatible or not, it rather provides detailed diagnosis, including the incompatibilities and for each one the location in the service interfaces where these incompatibilities occur. A measure of similarity between interfaces which considers outputs from the detection algorithm is proposed too. A visual report of the comparison analysis is also provided which pinpoints a set of incompatibilities that cause a behavioural interface not to simulate another one

Diagnosing and measuring incompatibilities between pairs of services

International audienceThis text presents a tool, from its design to its implementation, which detects all behavioural incompatibilities between two service interfaces. Unlike prior work, the proposed solution does not simply check whether two services are incompatible or not, it rather provides detailed diagnosis, including the incompatibilities and for each one the location in the service interfaces where these incompatibilities occur. A measure of similarity between interfaces which considers outputs from the detection algorithm is proposed too. A visual report of the comparison analysis is also provided which pinpoints a set of incompatibilities that cause a behavioural interface not to simulate another one

Analysis of incompatibilities between services: diagnosing all and identifying those which are fixable

National audienceThis text presents a tool, from its design to its implementation, which detects all incompatibilities between two service interfaces. Among all these incompatibilities, those which can be fixed by a mediator are identified. The tool focuses on behavioural dimension of service interfaces. Unlike prior work, the proposed solution does not simply check whether two services are incompatible or not, it rather provides detailed diagnosis, including the incompatibilities and for each one its location in the service interfaces. A measure of similarity between interfaces which considers outputs from the detection algorithm is proposed too. A visual report of the comparison analysis is also provided which pinpoints a set of incompatibilities that cause a behavioural interface not to simulate another one

Institute of Hematology and Transfusion Medicine — a novel approach of combining comprehensiveness, coordination, innovation and pro-quality measures for improving diagnosis, treatment, patient care, and the advancement of medical science

  W Polsce, podobnie jak w innych krajach europejskich, obserwuje się ciągły wzrost zapotrzebowa­nia na świadczenia zdrowotne w zakresie chorób krwi. Na to zjawisko składa się nie tylko obser­wowana od kilkudziesięciu lat zwiększona zapadalność na nowotwory układów krwiotwórczego i chłonnego, ale również dynamiczny rozwój metod diagnostycznych i leczniczych, jaki się dokonał w ostatnim czasie. Instytut Hematologii i Transfuzjologii jest referencyjną jednostką naukowo­-kliniczną prowadzącą badania naukowe i translacyjne w dziedzinie hematologii, transfuzjologii i dyscyplin pokrewnych oraz udziela świadczeń medycznych w tym zakresie. Instytut to nowoczesny ośrodek krajowy, w którym stawia się na skoordynowane leczenie i nowe technologie medyczne. W działalności medycznej personel kieruje się zasadą wielospecjalistycznego podejścia, co oznacza udział wszystkich niezbędnych specjalistów na etapie rozpoznawania i określania zaawansowania choroby, a także leczenia i prowadzenia rehabilitacji oraz obserwacji po leczeniu. Kompleksowe postępowanie zapewnia możliwość uzyskania najlepszych wyników terapii. Skoordynowana opieka medyczna, jaką swoim Pacjentom oferuje Instytut, przekłada się przede wszystkim na szybszy i lep­szy efekt medyczny. Dla osiągnięcia tego celu ważne są interoperacyjność i autentyczna współpraca między poszczególnymi jednostkami diagnostycznymi i medycznymi, a także innymi ośrodkami prowadzącymi leczenie specjalistyczne. Oprócz standardowych metod diagnostyki i leczenia Insty­tut oferuje możliwość wysokospecjalistycznego i nowatorskiego leczenia celowanego molekularnie, a także uczestnictwo w międzynarodowych badaniach klinicznych z zastosowaniem nowatorskich i eksperymentalnych sposobów leczenia chorych na nowotwory układów krwiotwórczego i chłonnego. Prowadzone przez Instytut badania naukowe zaowocowały możliwością stosowania nowoczesnych technik immunologicznych i genetycznych we wszystkich wymagających takich technologii proce­sach diagnostyczno-leczniczych. Procesy te są zadaniem złożonym i interdyscyplinarnym; dotyczą nie tylko prawidłowego rozpoznania choroby, ale również oceny markerów prognostyczno-predykcyj­nych, wczesnej diagnostyki i prewencji powikłań, doboru dawców i biorców przeszczepów komórek krwiotwórczych, a także oceny głębokości remisji. We współpracy z innymi podmiotami w kraju i za granicą Instytut uczestniczy w programie kompleksowego i skoordynowanego zachowania rozrodczości u kobiet chorych na nowotwory poddawanych chemio- i radioterapii. Przez ostatnie lata Instytut prowadził działania inwestycyjne, które pozwoliły wyposażyć poszczególne pracownie w innowacyjną aparaturę i specjalistyczne urządzenia. Dzięki specjalistycznym zasobom kadrowym, doświadczeniu hematopatologów oraz wspierającemu ich zespołowi biologów i biotechnologów Instytut dysponuje niezbędnym know-how do skutecznego wdrażania i komercjalizacji wyników badań naukowych. Dynamiczny rozwój tej dziedziny działalności prowadzi do powstawania inno­wacyjnych produktów tworzonych w ramach Krajowych Inteligentnych Specjalizacji. Taka sytuacja buduje przewagę konkurencyjną Instytutu w zakresie innowacyjnych technologii medycznych — nie tylko na poziomie krajowym, ale też na arenie międzynarodowej.    Like in all European countries, Poland has witnessed a continuing rise in healthcare services needed for treating hematological disease. Not only have morbidity rates increased in myeloid and lymphoid malignancies but, in parallel, a dynamic development of diagnostic methods and therapeutic treatments has occurred in recent times. The Institute of Hematology and Transfusion Medicine constitutes a reference centre in Poland committed to delivering scientific-clinical excel­lence where it undertakes scientific studies and translational research in hematology, transfusion medicine and related disciplines along with providing healthcare services in such fields. This is a modern medical centre focused on coordinating and integrating treatment using new medical technologies. A multidisciplinary strategy to medicine ensures that all necessary specialists are engaged in disease diagnoses and also for defining disease progression stages together with actual treatment, subsequent rehabilitation and follow-up monitoring. By adopting this comprehensive approach, optimal therapeutic solutions are thereby achieved; patients receive coordinated medi­cal healthcare, which above all else, results in faster and more effective treatments. In order to achieve such aims, it is vital that all diagnostic and medical units collaborate, including with those from other medical centres whenever added specialist treatment is required. In addition to standard diagnostics and treatment, the Institute provides highly specialised and innovative treat­ments that are molecularly targeted, as well as the opportunity of participating in international clinical trials, where innovative and experimental therapies are used on patients with myeloid and lymphoid malignancies. Such trials have enabled the Institute to apply modern immunological and genetic technologies to diagnoses-treatment. Performing such procedures requires a complex and multidisciplinary approach, not just for ensuring correct diagnoses, but for also assessing prognostic-predictive disease markers, making the diagnoses early, preventing complications, selecting appropriate donor-recipients for hematopoietic cell transplants and evaluating the extent of remission. In collaboration with other national centres and those abroad, the Institute is also engaged in complex and coordinated programmes devoted to preserving women’s fertility for those suffering from cancer and who are treated with chemo/radio-therapy. Over recent years, the Insti­tute has invested in furnishing individual laboratories with the latest equipment and specialised instrumentation. Because of its highly specialist staff, the wide experience of hematopathologists and the supporting teams of biologists and biotechnologists, the Institute has at its disposition the vital ‘know-how’ thereby allowing developments from scientific studies to become successfully im­plemented and commercialised. The dynamic rise in this area has driven the creation of innovative products under the National Smart Specialisation initiative; this giving the Institute a competitive advantage in developing new medical technologies, at both country and international levels

A Systematic Literature Review in Cross-browser Testing

Many users access web pages from different browsers looking for the same user experience in all of them. However, there are several causes that produce compatibility issues. Those defects affect functionalities and user interface components. In this paper we present a systematic literature review which aims to find and summarize existing techniques, tools and challenges related to crossbrowser testing. According to the results, the most used technique is the visual analysis. However, there are still challenges to face. The most important challenge is the identification of dynamic components in the user interface. Cross-browser compatibility topics are getting importance according to an increment in published articles. Nevertheless, there are techniques that are not completely developed yet and do not fully support test automation practices.Facultad de Informátic

A Systematic Literature Review in Cross-browser Testing

Many users access web pages from different browsers looking for the same user experience in all of them. However, there are several causes that produce compatibility issues. Those defects affect functionalities and user interface components. In this paper we present a systematic literature review which aims to find and summarize existing techniques, tools and challenges related to crossbrowser testing. According to the results, the most used technique is the visual analysis. However, there are still challenges to face. The most important challenge is the identification of dynamic components in the user interface. Cross-browser compatibility topics are getting importance according to an increment in published articles. Nevertheless, there are techniques that are not completely developed yet and do not fully support test automation practices.Facultad de Informátic

A Systematic Literature Review in Cross-browser Testing

Many users access web pages from different browsers looking for the same user experience in all of them. However, there are several causes that produce compatibility issues. Those defects affect functionalities and user interface components. In this paper we present a systematic literature review which aims to find and summarize existing techniques, tools and challenges related to crossbrowser testing. According to the results, the most used technique is the visual analysis. However, there are still challenges to face. The most important challenge is the identification of dynamic components in the user interface. Cross-browser compatibility topics are getting importance according to an increment in published articles. Nevertheless, there are techniques that are not completely developed yet and do not fully support test automation practices.Facultad de Informátic

Semantic Service Substitution in Pervasive Environments

A computing infrastructure where everything is a service offers many new system and application possibilities. Among the main challenges, however, is the issue of service substitution for the application execution in such heterogeneous environments. An application would like to continue to execute even when a service disappears, or it would like to benefit from the environment by using better services with better QoS when possible. In this article, we define a generic service model and describe the equivalence relations between services considering the functionalities they propose and their non functional QoS properties. We define semantic equivalence relations between services and equivalence degree between non functional QoS properties. Using these relations we propose semantic substitution mechanisms upon the appearance and disappearance of services that fits the application needs. We developed a prototype as a proof of concept and evaluated its efficiency over a real use case

Tricistronic Lentivirus vector construction using scar-less DNA assembly methods and web-based software j5 to help study GRK4

About one third of the world’s population is affected by hypertension, or high blood pressure, which increases an individual’s risk for cardiovascular disease. A major contributor to hypertension is dietary sodium intake. To assess an individual’s risk for hypertension, patients are put on a low sodium diet. However, research has shown that low salt intake can also have different and potentially harmful effects. Because of this, a genetic screen for salt sensitivity is needed to asses an individual’s salt sensitivity classification before testing and these results matched to a recommended dietary change. The kidney regulates the body’s fluid volume, so genetic factor within the renal system could be used for such a genetic screen. The dopaminergic system within renal proximal tubule cells is responsible for the majority of excretion and is highly influenced by a G-protein kinase, GRK4. The expression of GRK4, its association with the dopaminergic system, and the activity in varying salt sensitivity cell types can be indicators for salt sensitivity and provide a definitive diagnosis of the type of salt-related hypertension. Thus, a finely tuned treatment plan would be possible. To help study GRK4 expression, tricistronic lentivirus delivery systems were constructed to measure protein expression in vivo. To construct the vectors, scar-less DNA assembly methods allow for simpler and multipart construction, while web-based software j5 was developed to optimize cost, time efficiency, and reduce construction difficulty. Developing tricistronic vectors allows for introduction of a protein with two modes of measurement separated by 2A self-cleaving peptide sequences that impart protein autonomy. Bicistronic vectors, pLVX-GZ and pLVX-GC were constructed for utility and to establish a protocol for constructing tricistronic vectors. A tricistronic vector pLVX-GZC2 was been constructed containing GRK4, Zeocin resistance, and a fluorescence protein with P2A and T2A. Construction of such vectors will serve as a fast and cost-effective platform to fine-tune the differential diagnosis of salt-related hypertension